The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ying, H.
Right arrow Articles by Parnes, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ying, H.
Right arrow Articles by Parnes, J. R.

The Journal of Immunology, Vol 154, Issue 6 2743-2752, Copyright © 1995 by American Association of Immunologists

ARTICLES

Structure of the mouse CD72 (Lyb-2) gene and its alternatively spliced transcripts [published erratum appears in J Immunol 1995 Aug 1;155(3):1637]

H Ying, E Nakayama, WH Robinson and JR Parnes
Department of Medicine, Stanford University School of Medicine, CA 94305.

The complete sequence of the CD72 gene from the C57L mouse, including the 5' and 3' flanking sequences, is reported. The gene spans 6830 base pairs and includes nine exons surrounding eight introns. It does not have an obvious TATAA box, so it belongs to a group of genes with TATA- less promoters that are regulated during mammalian immunodifferentiation. cDNA sequence comparisons among CD72a, CD72b, and CD72c alleles have demonstrated two distinct seven amino acid insertion/deletions among these allelic variants. Based on our genomic sequence studies as well as PCR analyses, we found that different strains of mice can alternatively or exclusively use either of two AG sites surrounding the 21-bp insertion/deletions as 3' splice sites in an allele-specific manner. Other alternative splicing events, such as exon skipping, also contribute to CD72 polymorphism. In mouse splenic B cells there are allele-specific distributions of CD72 mRNAs that contain sequences from both exon 3 and exon 4, from either exon 3 or exon 4, or from neither exon 3 nor 4. It is unclear what the in vivo function might be of the proteins encoded by the mRNA forms lacking these exon sequences.


This article has been cited by other articles:


Home page
 Int ImmunolHome page
N. Fujiwara, S. Hidano, H. Mamada, K. Ogasawara, D. Kitamura, M. D Cooper, N. Hozumi, C.-l. H Chen, and R. Goitsuka
A novel avian homologue of CD72, chB1r, down modulates BCR-mediated activation signals
Int. Immunol., May 1, 2006; 18(5): 775 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Y. Hitomi, N. Tsuchiya, A. Kawasaki, J. Ohashi, T. Suzuki, C. Kyogoku, T. Fukazawa, S. Bejrachandra, U. Siriboonrit, D. Chandanayingyong, et al.
CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B
Hum. Mol. Genet., December 1, 2004; 13(23): 2907 - 2917.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Moreau-Fauvarque, A. Kumanogoh, E. Camand, C. Jaillard, G. Barbin, I. Boquet, C. Love, E. Y. Jones, H. Kikutani, C. Lubetzki, et al.
The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion
J. Neurosci., October 8, 2003; 23(27): 9229 - 9239.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
A. Catteau, O. Kalinina, M.-C. Wagner, V. Deubel, M.-P. Courageot, and P. Despres
Dengue virus M protein contains a proapoptotic sequence referred to as ApoptoM
J. Gen. Virol., October 1, 2003; 84(10): 2781 - 2793.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Goitsuka, H. Mamada, D. Kitamura, M. D. Cooper, and C.-l. H. Chen2
Genomic Structure and Transcriptional Regulation of the Early B Cell Gene chB1
J. Immunol., August 1, 2001; 167(3): 1454 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Ariizumi, G.-L. Shen, S. Shikano, R. Ritter III, P. Zukas, D. Edelbaum, A. Morita, and A. Takashima
Cloning of a Second Dendritic Cell-associated C-type Lectin (Dectin-2) and Its Alternatively Spliced Isoforms
J. Biol. Chem., April 14, 2000; 275(16): 11957 - 11963.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Nakano, S. Mori, H. Yonekawa, H. Nariuchi, A. Matsuzawa, and T. Kakiuchi
A Novel Mutant Gene Involved in T-Lymphocyte-Specific Homing Into Peripheral Lymphoid Organs on Mouse Chromosome 4 
Blood, April 15, 1998; 91(8): 2886 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Ying, J.-F. Chang, and J. R. Parnes
PU.1/Spi-1 Is Essential for the B Cell-Specific Activity of the Mouse CD72 Promoter
J. Immunol., March 1, 1998; 160(5): 2287 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Ariizumi, G.-L. Shen, S. Shikano, S. Xu, R. Ritter III, T. Kumamoto, D. Edelbaum, A. Morita, P. R. Bergstresser, and A. Takashima
Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning
J. Biol. Chem., June 23, 2000; 275(26): 20157 - 20167.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.