| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 154, Issue 5 2413-2422, Copyright © 1995 by American Association of Immunologists
ARTICLES |
CJ Vlahos, WF Matter, RF Brown, AE Traynor-Kaplan, PG Heyworth, ER Prossnitz, RD Ye, P Marder, JA Schelm and KJ Rothfuss
Lilly Research Labortories, Eli Lilly and Company, Indianapolis, IN 46285.
Neutrophils contain a multicomponent NADPH oxidase system that is involved in the production of microbicidal oxidants. Stimulation of human neutrophils with the peptide FMLP activates this respiratory burst enzyme to produce superoxide and also has been shown to result in activation of phosphatidylinositol (Ptdlns) 3-kinase. Treatment of human neutrophils with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a potent and specific inhibitor of Ptdlns 3-kinase, resulted in complete inhibition of Ptdlns 3-kinase activity as well as in inhibition of superoxide production in FMLP-treated neutrophils in suspension; FMLP-stimulated oxidant production in adherent cells was also abolished. Treatment of human neutrophils with PMA resulted in production of superoxide without activation of Ptdlns 3-kinase; LY294002 did not block superoxide production in neutrophils exposed to PMA. In addition, LY294002 did not inhibit cellfree NADPH oxidase activation, CD11b-dependent adhesion, actin polymerization in response to FMLP, or FMLP-induced calcium flux. These results suggest that the signal transduction pathway of the FMLP-receptor involves activation of Ptdlns 3-kinase, which is required for subsequent superoxide production induced by the chemotactic peptide. Furthermore, Ptdlns 3-kinase may be located directly upstream of protein kinase C or other protein kinases, which in turn activate the NADPH oxidase system.
This article has been cited by other articles:
|
|
 |
|
  N. J. D. McLaughlin, A. Banerjee, S. Y. Khan, J. L. Lieber, M. R. Kelher, F. Gamboni-Robertson, F. R. Sheppard, E. E. Moore, G. W. Mierau, D. J. Elzi, et al. Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67phox and p40phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils J. Immunol., June 15, 2008; 180(12): 8192 - 8203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nanamori, J. Chen, X. Du, and R. D. Ye Regulation of Leukocyte Degranulation by cGMP-Dependent Protein Kinase and Phosphoinositide 3-Kinase: Potential Roles in Phosphorylation of Target Membrane SNARE Complex Proteins in Rat Mast Cells J. Immunol., January 1, 2007; 178(1): 416 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Uddin, A. R. Hussain, A. K. Siraj, P. S. Manogaran, N. A. Al-Jomah, A. Moorji, V. Atizado, F. Al-Dayel, A. Belgaumi, H. El-Solh, et al. Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival Blood, December 15, 2006; 108(13): 4178 - 4186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Benetti and B. Roizman Protein Kinase B/Akt Is Present in Activated Form throughout the Entire Replicative Cycle of {Delta}US3 Mutant Virus but Only at Early Times after Infection with Wild-Type Herpes Simplex Virus 1. J. Virol., April 1, 2006; 80(7): 3341 - 3348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Reistad and E. Mariussen A Commercial Mixture of the Brominated Flame Retardant Pentabrominated Diphenyl Ether (DE-71) Induces Respiratory Burst in Human Neutrophil Granulocytes In Vitro Toxicol. Sci., September 1, 2005; 87(1): 57 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Uddin, A. R. Hussain, K. A. Al-Hussein, P. S. Manogaran, A. Wickrema, M. I. Gutierrez, and K. G. Bhatia Inhibition of Phosphatidylinositol 3'-Kinase/AKT Signaling Promotes Apoptosis of Primary Effusion Lymphoma Cells Clin. Cancer Res., April 15, 2005; 11(8): 3102 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Shin, J. Edl, S. Biswas, P. C. Lin, R. Mernaugh, and C. L. Arteaga Proapoptotic Activity of Cell-Permeable Anti-Akt Single-Chain Antibodies Cancer Res., April 1, 2005; 65(7): 2815 - 2824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Williams and C. O. S. Savage Characterization of the Regulation and Functional Consequences of p21ras Activation in Neutrophils by Antineutrophil Cytoplasm Antibodies J. Am. Soc. Nephrol., January 1, 2005; 16(1): 90 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Wynes, S. K. Frankel, and D. W. H. Riches IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal J. Leukoc. Biol., November 1, 2004; 76(5): 1019 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Burelout, N. Thibault, S. Levasseur, S. Simard, P. H. Naccache, and S. G. Bourgoin Prostaglandin E2 Inhibits the Phospholipase D Pathway Stimulated by Formyl-methionyl-leucyl-phenylalanine in Human Neutrophils. Involvement of EP2 Receptors and Phosphatidylinositol 3-kinase {gamma} Mol. Pharmacol., August 1, 2004; 66(2): 293 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Cheng, P. Zimniak, and J.-P. Raufman Transactivation of the Epidermal Growth Factor Receptor Mediates Cholinergic Agonist-Induced Proliferation of H508 Human Colon Cancer Cells Cancer Res., October 15, 2003; 63(20): 6744 - 6750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. G. Shenoy, G. J. Gleich, and L. L. Thomas Eosinophil Major Basic Protein Stimulates Neutrophil Superoxide Production by a Class IA Phosphoinositide 3-Kinase and Protein Kinase C-{zeta}-Dependent Pathway J. Immunol., October 1, 2003; 171(7): 3734 - 3741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Xu, S.-E. Simpson, T. J. Scialla, A. Bagg, and M. Carroll Survival of acute myeloid leukemia cells requires PI3 kinase activation Blood, August 1, 2003; 102(3): 972 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, D. W. Powell, M. J. Rane, S. Singh, W. Butt, J. B. Klein, and K. R. McLeish Akt Phosphorylates p47phox and Mediates Respiratory Burst Activity in Human Neutrophils J. Immunol., May 15, 2003; 170(10): 5302 - 5308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yasui, Y. Sekiguchi, M. Ichikawa, H. Nagumo, T. Yamazaki, A. Komiyama, and H. Suzuki Granulocyte macrophage-colony stimulating factor delays neutrophil apoptosis and primes its function through Ia-type phosphoinositide 3-kinase J. Leukoc. Biol., November 1, 2002; 72(5): 1020 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Monick, P. K. Robeff, N. S. Butler, D. M. Flaherty, A. B. Carter, M. W. Peterson, and G. W. Hunninghake Phosphatidylinositol 3-Kinase Activity Negatively Regulates Stability of Cyclooxygenase 2 mRNA J. Biol. Chem., August 30, 2002; 277(36): 32992 - 33000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Gibbs, K. E. S. Plath, H. H. Wolff, and J. Grabbe Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization J. Leukoc. Biol., August 1, 2002; 72(2): 391 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Iwabuchi and I. Nagaoka Lactosylceramide-enriched glycosphingolipid signaling domain mediates superoxide generation from human neutrophils Blood, July 30, 2002; 100(4): 1454 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dierov, Q. Xu, R. Dierova, and M. Carroll TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle Blood, March 1, 2002; 99(5): 1758 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Nijhuis, J.-W. J Lammers, L. Koenderman, and P. J. Coffer Src kinases regulate PKB activation and modulate cytokine and chemoattractant-controlled neutrophil functioning J. Leukoc. Biol., January 1, 2002; 71(1): 115 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mansell, N. Khelef, P. Cossart, and L. A. J. O'Neill Internalin B Activates Nuclear Factor-kappa B via Ras, Phosphoinositide 3-Kinase, and Akt J. Biol. Chem., November 16, 2001; 276(47): 43597 - 43603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ottonello, A. L. Epstein, M. Mancini, M. Amelotti, P. Dapino, and F. Dallegri Monoclonal Lym-1 antibody-targeted lysis of B lymphoma cells by neutrophils. Evidence for two mechanisms of Fc{gamma}RII-dependent cytolysis J. Leukoc. Biol., November 1, 2000; 68(5): 662 - 668. [Abstract] [Full Text]
|
|
|
|
|
|
S. Verploegen, J.-W. J. Lammers, L. Koenderman, and P. J. Coffer Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent kinase Blood, November 1, 2000; 96(9): 3215 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Chu, W. R. Reenstra, D. L. Orlow, and K. K. H. Svoboda Erk and PI-3 Kinase Are Necessary for Collagen Binding and Actin Reorganization in Corneal Epithelia Invest. Ophthalmol. Vis. Sci., October 1, 2000; 41(11): 3374 - 3382. [Abstract] [Full Text]
|
|
|
|
|
|
O. T. Lynch, M. A. Giembycz, I. Daniels, P. J. Barnes, and M. A. Lindsay Pleiotropic role of lyn kinase in leukotriene B4-induced eosinophil activation Blood, June 1, 2000; 95(11): 3541 - 3547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Williams and A. J. Ridley Lipopolysaccharide Induces Actin Reorganization and Tyrosine Phosphorylation of Pyk2 and Paxillin in Monocytes and Macrophages J. Immunol., February 15, 2000; 164(4): 2028 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, H. Jiang, W. Xie, Z. Zhang, A. V. Smrcka, and D. Wu Roles of PLC-2 and -3 and PI3K in Chemoattractant-Mediated Signal Transduction Science, February 11, 2000; 287(5455): 1046 - 1049. [Abstract] [Full Text]
|
|
|
|
 |
|
 D Wu, C. Huang, and H Jiang Roles of phospholipid signaling in chemoattractant-induced responses J. Cell Sci., January 9, 2000; 113(17): 2935 - 2940. [Abstract] [PDF]
|
|
|
|
|
|
A. P. Feranchak, R. M. Roman, R. B. Doctor, K. D. Salter, A. Toker, and J. G. Fitz The Lipid Products of Phosphoinositide 3-Kinase Contribute to Regulation of Cholangiocyte ATP and Chloride Transport J. Biol. Chem., October 22, 1999; 274(43): 30979 - 30986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Edinger, M. D. Rokaw, and J. P. Johnson Vasopressin stimulates sodium transport in A6 cells via a phosphatidylinositide 3-kinase-dependent pathway Am J Physiol Renal Physiol, October 1, 1999; 277(4): F575 - F579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Maciejewski-Lenoir, S. Chen, L. Feng, R. Maki, and K. B. Bacon Characterization of Fractalkine in Rat Brain Cells: Migratory and Activation Signals for CX3CR-1-Expressing Microglia J. Immunol., August 1, 1999; 163(3): 1628 - 1635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Geijsen, S. van Delft, J. A.M. Raaijmakers, J.-W. J. Lammers, J. G. Collard, L. Koenderman, and P. J. Coffer Regulation of p21rac Activation in Human Neutrophils Blood, August 1, 1999; 94(3): 1121 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Benard, B. P. Bohl, and G. M. Bokoch Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases J. Biol. Chem., May 7, 1999; 274(19): 13198 - 13204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Bewick, C. Fernandes, A. D. Pitt, H. H. Rasmussen, and D. W. Whalley Mechanisms of Na+-K+ pump regulation in cardiac myocytes during hyposmolar swelling Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1091 - C1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cox, C.-C. Tseng, G. Bjekic, and S. Greenberg A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension J. Biol. Chem., January 15, 1999; 274(3): 1240 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Powell, S. Gravel, and F. Halwani 5-oxo-6,8,11,14-Eicosatetraenoic Acid Is a Potent Stimulator of L-Selectin Shedding, Surface Expression of CD11b, Actin Polymerization, and Calcium Mobilization in Human Eosinophils Am. J. Respir. Cell Mol. Biol., January 1, 1999; 20(1): 163 - 170. [Abstract] [Full Text]
|
|
|
|
|
|
M. Tardif, M.-J. Rabiet, T. Christophe, M.-D. Milcent, and F. Boulay Isolation and Characterization of a Variant HL60 Cell Line Defective in the Activation of the NADPH Oxidase by Phorbol Myristate Acetate J. Immunol., December 15, 1998; 161(12): 6885 - 6895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Kivens, S. W. Hunt III, J. L. Mobley, T. Zell, C. L. Dell, B. E. Bierer, and Y. Shimizu Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase Mol. Cell. Biol., September 1, 1998; 18(9): 5291 - 5307. [Abstract] [Full Text]
|
|
|
|
|
|
A. P. Feranchak, R. M. Roman, E. M. Schwiebert, and J. G. Fitz Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release J. Biol. Chem., June 12, 1998; 273(24): 14906 - 14911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lindsay, R. S. Perkins, P. J. Barnes, and M. A. Giembycz Leukotriene B4 Activates the NADPH Oxidase in Eosinophils by a Pertussis Toxin-Sensitive Mechanism That Is Largely Independent of Arachidonic Acid Mobilization J. Immunol., May 1, 1998; 160(9): 4526 - 4534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Capodici, S. Hanft, M. Feoktistov, and M. H. Pillinger Phosphatidylinositol 3-Kinase Mediates Chemoattractant-Stimulated, CD11b/CD18-Dependent Cell-Cell Adhesion of Human Neutrophils: Evidence for an ERK-Independent Pathway J. Immunol., February 15, 1998; 160(4): 1901 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu, W. Ning, R. Dantzer, G. G. Freund, and K. W. Kelley Activation of Protein Kinase C-{zeta} and Phosphatidylinositol 3'-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I J. Immunol., February 1, 1998; 160(3): 1393 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Nusse, L. Serrander, R. Foyouzi-Youssefi, A. Monod, D. P. Lew, and K.-H. Krause Store-operated Ca2+ Influx and Stimulation of Exocytosis in HL-60 Granulocytes J. Biol. Chem., November 7, 1997; 272(45): 28360 - 28367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Knall, G. S. Worthen, and G. L. Johnson Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases PNAS, April 1, 1997; 94(7): 3052 - 3057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Krump, JasbinderS. Sanghera, StevenL. Pelech, W. Furuya, and S. Grinstein Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils J. Biol. Chem., January 10, 1997; 272(2): 937 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ptasznik, E. R. Prossnitz, D. Yoshikawa, A. Smrcka, A. E. Traynor-Kaplan, and G. M. Bokoch A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils J. Biol. Chem., October 11, 1996; 271(41): 25204 - 25207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
GregoryP. Downey, JeffreyR. Butler, J. Brumell, N. Borregaard, L. Kjeldsen, AndreaK. Sue-A-Quan, and S. Grinstein Chemotactic Peptide-induced Activation of MEK-2, the Predominant Isoform in Human Neutrophils. INHIBITION BY WORTMANNIN J. Biol. Chem., August 30, 1996; 271(35): 21005 - 21011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Scheid and V. Duronio Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines J. Biol. Chem., July 26, 1996; 271(30): 18134 - 18139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Naccache, S. Levasseur, G. Lachance, S. Chakravarti, S. G. Bourgoin, and S. R. McColl Stimulation of Human Neutrophils by Chemotactic Factors Is Associated with the Activation of Phosphatidylinositol 3-Kinase gamma J. Biol. Chem., July 28, 2000; 275(31): 23636 - 23641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Ballif, A. Shimamura, E. Pae, and J. Blenis Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative Agent N-alpha -tosyl-L-phenylalanyl Chloromethyl Ketone J. Biol. Chem., April 6, 2001; 276(15): 12466 - 12475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. McAdara Berkowitz, S. D. Catz, J. L. Johnson, J. M. Ruedi, V. Thon, and B. M. Babior JFC1, a Novel Tandem C2 Domain-containing Protein Associated with the Leukocyte NADPH Oxidase J. Biol. Chem., May 25, 2001; 276(22): 18855 - 18862. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
