| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 154, Issue 5 2358-2365, Copyright © 1995 by American Association of Immunologists
ARTICLES |
RA Panettieri Jr, AL Lazaar, E Pure and SM Albelda
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia.
Asthma is a disease of airway inflammation and hyper-reactivity associated with lymphocytic infiltration in the bronchial submucosa. We recently demonstrated that human airway smooth muscle (ASM) cells express the cell adhesion molecules ICAM-1 and VCAM-1, which are up- regulated by cytokines such as TNF-alpha, and which mediate binding of activated T lymphocytes. In this study, we examined whether an increase in [cAMP]i, presumably via activation of cAMP-dependent protein kinase, modulates TNF-alpha-induced ICAM-1 and VCAM-1 on ASM. We found that treatment of ASM with either forskolin, which directly activates adenylyl cyclase, or with cholera toxin, which activates the heterotrimeric GTP-binding protein, Gs, inhibited TNF-alpha-induced cell adhesion molecule expression. In addition, treatment with either isoproterenol or prostaglandin E2, which activates receptors coupled to Gs and increases [cAMP]i, also inhibited TNF-alpha-induced expression of ICAM-1 and VCAM-1 on ASM. Furthermore, adhesion of activated T cells to TNF-alpha-stimulated ASM was inhibited by treating the ASM cells with either forskolin or PGE2. These data suggest that cAMP-dependent protein kinase activation decreases cytokine-induced expression of cell adhesion molecules on ASM cells, modulates T cell binding to airway myocytes and, thus, suggests novel therapeutic approaches to airway inflammation.
This article has been cited by other articles:
|
|
 |
|
  O. Tliba, Y. Amrani, and R. A. Panettieri Jr Is Airway Smooth Muscle the "Missing Link" Modulating Airway Inflammation in Asthma? Chest, January 1, 2008; 133(1): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chassin, M. W. Hornef, M. Bens, M. Lotz, J.-M. Goujon, S. Vimont, G. Arlet, A. Hertig, E. Rondeau, and A. Vandewalle Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin J. Exp. Med., November 26, 2007; 204(12): 2837 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Chung Evaluation of Selective Prostaglandin E2 (PGE2) Receptor Agonists as Therapeutic Agents for the Treatment of Asthma Sci. Signal., September 27, 2005; 2005(303): pe47 - pe47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Schillace, S. F. Andrews, S. G. Galligan, K. A. Burton, H. J. Starks, H. G. A. Bouwer, G. S. McKnight, M. P. Davey, and D. W. Carr The Role of Protein Kinase A Anchoring via the RII{alpha} Regulatory Subunit in the Murine Immune System J. Immunol., June 1, 2005; 174(11): 6847 - 6853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Amrani, O. Tliba, D. Choubey, C.-D. Huang, V. P. Krymskaya, A. Eszterhas, A. L. Lazaar, and R. A. Panettieri Jr. IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L1063 - L1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nakae, Y. Komiyama, H. Yokoyama, A. Nambu, M. Umeda, M. Iwase, I. Homma, K. Sudo, R. Horai, M. Asano, et al. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response Int. Immunol., April 1, 2003; 15(4): 483 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dohadwala, R. K. Batra, J. Luo, Y. Lin, K. Krysan, M. Pold, S. Sharma, and S. M. Dubinett Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion J. Biol. Chem., December 20, 2002; 277(52): 50828 - 50833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. AMRANI, P. E. MOORE, R. HOFFMAN, S. A. SHORE, and R. A. PANETTIERI JR. Interferon-gamma Modulates Cysteinyl Leukotriene Receptor-1 Expression and Function in Human Airway Myocytes Am. J. Respir. Crit. Care Med., December 1, 2001; 164(11): 2098 - 2101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Page, A. J. Ammit, J. L. Black, and C. L. Armour Human mast cell and airway smooth muscle cell interactions: implications for asthma Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1313 - L1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Amrani, A. L. Lazaar, R. Hoffman, K. Amin, S. Ousmer, and R. A. Panettieri Jr. Activation of p55 Tumor Necrosis Factor-alpha Receptor-1 Coupled to Tumor Necrosis Factor Receptor-Associated Factor 2 Stimulates Intercellular Adhesion Molecule-1 Expression by Modulating a Thapsigargin-Sensitive Pathway in Human Tracheal Smooth Muscle Cells Mol. Pharmacol., July 1, 2000; 58(1): 237 - 245. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Romberger, P. Heires, S. I. Rennard, and T. A. Wyatt beta -Adrenergic agonist modulation of monocyte adhesion to airway epithelial cells in vitro Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L139 - L147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jaakkola, K. Kaunismaki, S. Tohka, G. Yegutkin, E. Vanttinen, T. Havia, L. J. Pelliniemi, M. Virolainen, S. Jalkanen, and M. Salmi Human Vascular Adhesion Protein-1 in Smooth Muscle Cells Am. J. Pathol., December 1, 1999; 155(6): 1953 - 1965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Amrani, A. L. Lazaar, and R. A. Panettieri Jr. Up-Regulation of ICAM-1 by Cytokines in Human Tracheal Smooth Muscle Cells Involves an NF-{kappa}B-Dependent Signaling Pathway That Is Only Partially Sensitive to Dexamethasone J. Immunol., August 15, 1999; 163(4): 2128 - 2134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rocca, L. M. Spain, G. Ciabattoni, C. Patrono, and G. A. FitzGerald Differential Expression and Regulation of Cyclooxygenase Isozymes in Thymic Stromal Cells J. Immunol., April 15, 1999; 162(8): 4589 - 4597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. GAUVREAU, R. M. WATSON, and P. M. O'BYRNE Protective Effects of Inhaled PGE2 on Allergen-induced Airway Responses and Airway Inflammation Am. J. Respir. Crit. Care Med., January 1, 1999; 159(1): 31 - 36. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. J. Barnes, K. F. Chung, and C. P. Page Inflammatory Mediators of Asthma: An Update Pharmacol. Rev., December 1, 1998; 50(4): 515 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gauvreau, M Jordana, R. Watson, D. Cockroft, and P. O'Byrne Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthmatic subjects Am. J. Respir. Crit. Care Med., December 1, 1997; 156(6): 1738 - 1745. [Abstract] [Full Text]
|
|
|
|
|
|
V. P. Krymskaya, R. Hoffman, A. Eszterhas, V. Ciocca, and R. A. Panettieri Jr. TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells Am J Physiol Lung Cell Mol Physiol, December 1, 1997; 273(6): L1220 - L1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Braun, P. Pietsch, A. Zepp, K. Schror, G. Baumann, and S. B. Felix Regulation of Tumor Necrosis Factor-{alpha} and Interleukin-1ß Induced Adhesion Molecule Expression in Human Vascular Smooth Muscle Cells by cAMP Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2568 - 2575. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
