The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Piskurich, J. F.
Right arrow Articles by Kaetzel, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piskurich, J. F.
Right arrow Articles by Kaetzel, C. S.

The Journal of Immunology, Vol 154, Issue 4 1735-1747, Copyright © 1995 by American Association of Immunologists

ARTICLES

Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species

JF Piskurich, MH Blanchard, KR Youngman, JA France and CS Kaetzel
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106.

Transcytosis of polymeric Ig (pIg) by mucosal epithelial cells is mediated by the polymeric Ig receptor (pIgR). Here we describe the characterization of a 3095-bp mouse pIgR cDNA, which encodes a protein of 771 amino acids. Northern blot analysis detected a single mouse pIgR transcript of 3.9 kb, expressed at high levels in small intestine and liver, and at low levels in lung. Alignment of the amino acid sequences of mouse, rat, human, bovine, and rabbit pIgR revealed that functional regions of the molecule are conserved across species. In the extracellular region, conserved motifs include: a 23-amino acid pIg- binding site, 11 intradomain disulfide bonds, consensus sites for N- glycosylation, and a putative cleavage site at which the extracellular region of pIgR (secretory component) is released from the plasma membrane. A 10-amino acid sequence within the transmembrane region is highly conserved, possibly reflecting a mechanism for transmitting signals from the extracellular region to the cytoplasmic tail. Conservation within the cytoplasmic tail of pIgR is clustered in motifs that mediate polarized sorting, endocytosis, and transcytosis.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
R. Braathen, V. S. Hohman, P. Brandtzaeg, and F.-E. Johansen
Secretory Antibody Formation: Conserved Binding Interactions between J Chain and Polymeric Ig Receptor from Humans and Amphibians
J. Immunol., February 1, 2007; 178(3): 1589 - 1597.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
E. Umemoto, T. Tanaka, H. Kanda, S. Jin, K. Tohya, K. Otani, T. Matsutani, M. Matsumoto, Y. Ebisuno, M. H. Jang, et al.
Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow
J. Exp. Med., June 12, 2006; 203(6): 1603 - 1614.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. C. Rice, T. Peng, J. S. Spence, H.-Q. Wang, R. M. Goldblum, B. Corthesy, and B. J. Nowicki
Pyelonephritic Escherichia coli Expressing P Fimbriae Decrease Immune Response of the Mouse Kidney
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3583 - 3591.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. J. Lewis, R. J. Pleass, M. R. Batten, J. D. Atkin, and J. M. Woof
Structural Requirements for the Interaction of Human IgA with the Human Polymeric Ig Receptor
J. Immunol., November 15, 2005; 175(10): 6694 - 6701.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Elm, R. Braathen, S. Bergmann, R. Frank, J.-P. Vaerman, C. S. Kaetzel, G. S. Chhatwal, F.-E. Johansen, and S. Hammerschmidt
Ectodomains 3 and 4 of Human Polymeric Immunoglobulin Receptor (hpIgR) Mediate Invasion of Streptococcus pneumoniae into the Epithelium
J. Biol. Chem., February 20, 2004; 279(8): 6296 - 6304.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Lu, M. E. Lamm, H. Li, B. Corthesy, and J.-R. Zhang
The Human Polymeric Immunoglobulin Receptor Binds to Streptococcus pneumoniae via Domains 3 and 4
J. Biol. Chem., November 28, 2003; 278(48): 48178 - 48187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. L. Jenkins, J. Wang, M. Vazir, J. Vela, O. Sahagun, P. Gabbay, L. Hoang, R. L. Diaz, R. Aranda, and M. G. Martin
Role of passive and adaptive immunity in influencing enterocyte-specific gene expression
Am J Physiol Gastrointest Liver Physiol, October 1, 2003; 285(4): G714 - G725.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. M. Hempen, K. M. Phillips, P. S. Conway, K. H. Sandoval, T. A. Schneeman, H.-J. Wu, and C. S. Kaetzel
Transcriptional Regulation of the Human Polymeric Ig Receptor Gene: Analysis of Basal Promoter Elements
J. Immunol., August 15, 2002; 169(4): 1912 - 1921.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. R. Bruce and M. L. Peterson
Multiple features contribute to efficient constitutive splicing of an unusually large exon
Nucleic Acids Res., June 1, 2001; 29(11): 2292 - 2302.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Phillips-Quagliata, S. Patel, J.-K. Han, S. Arakelov, T. D. Rao, M. J. Shulman, S. Fazel, R. B. Corley, M. Everett, M. H. Klein, et al.
The IgA/IgM Receptor Expressed on a Murine B Cell Lymphoma Is Poly-Ig Receptor
J. Immunol., September 1, 2000; 165(5): 2544 - 2555.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Kamata, F. Nogaki, S. Fagarasan, T. Sakiyama, I. Kobayashi, S. Miyawaki, K. Ikuta, E. Muso, H. Yoshida, S. Sasayama, et al.
Increased Frequency of Surface IgA-Positive Plasma Cells in the Intestinal Lamina Propria and Decreased IgA Excretion in Hyper IgA (HIGA) Mice, a Murine Model of IgA Nephropathy with Hyperserum IgA
J. Immunol., August 1, 2000; 165(3): 1387 - 1394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. FERKOL, E. ECKMAN, S. SWAIDANI, C. SILSKI, and P. DAVIS
Transport of Bifunctional Proteins Across Respiratory Epithelial Cells via the Polymeric Immunoglobulin Receptor
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 944 - 951.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-i. Shimada, M. Kawaguchi-Miyashita, A. Kushiro, T. Sato, M. Nanno, T. Sako, Y. Matsuoka, K. Sudo, Y.-i. Tagawa, Y. Iwakura, et al.
Generation of Polymeric Immunoglobulin Receptor-Deficient Mouse with Marked Reduction of Secretory IgA
J. Immunol., November 15, 1999; 163(10): 5367 - 5373.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Crottet, M. C. Peitsch, C. Servis, and B. Corthesy
Covalent Homodimers of Murine Secretory Component Induced by Epitope Substitution Unravel the Capacity of the Polymeric Ig Receptor to Dimerize Noncovalently in the Absence of IgA Ligand
J. Biol. Chem., October 29, 1999; 274(44): 31445 - 31455.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
F.-E. Johansen, M. Pekna, I. N. Norderhaug, B. Haneberg, M. A. Hietala, P. Krajci, C. Betsholtz, and P. Brandtzaeg
Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component-Deficient Mice
J. Exp. Med., October 4, 1999; 190(7): 915 - 922.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. M. Adamski and J. Demmer
Two Stages of Increased IgA Transfer During Lactation in the Marsupial, Trichosurus vulpecula (Brushtail Possum)
J. Immunol., May 15, 1999; 162(10): 6009 - 6015.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Roe, I. N. Norderhaug, P. Brandtzaeg, and F.-E. Johansen
Fine Specificity of Ligand-Binding Domain 1 in the Polymeric Ig Receptor: Importance of the CDR2-Containing Region for IgM Interaction
J. Immunol., May 15, 1999; 162(10): 6046 - 6052.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. G. Martin, J. Wang, T. W. H. Li, J. T. Lam, E. M. Gutierrez, R. S. Solorzano-Vargas, and A. H. V. Tsai
Characterization of the 5'-flanking region of the murine polymeric IgA receptor gene
Am J Physiol Gastrointest Liver Physiol, October 1, 1998; 275(4): G778 - G788.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. Sarkar, N. N. Gangopadhyay, Z. Moldoveanu, J. Mestecky, and C. B. Stephensen
Vitamin A Is Required for Regulation of Polymeric Immunoglobulin Receptor (pIgR) Expression by Interleukin-4 and Interferon-gamma in a Human Intestinal Epithelial Cell Line
J. Nutr., July 1, 1998; 128(7): 1063 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
T Su and K. Stanley
Opposite sorting and transcytosis of the polymeric immunoglobulin receptor in transfected endothelial and epithelial cells
J. Cell Sci., January 5, 1998; 111(9): 1197 - 1206.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
J. F. Piskurich, Y. Wang, M. W. Linhoff, L. C. White, and J. P.-Y. Ting
Identification of Distinct Regions of 5' Flanking DNA That Mediate Constitutive, IFN-{gamma}, STAT1, and TGF-{beta}-Regulated Expression of the Class II Transactivator Gene
J. Immunol., January 1, 1998; 160(1): 233 - 240.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C.-L. Ha and B. Woodward
Reduction in the Quantity of the Polymeric Immunoglobulin Receptor Is Sufficient to Account for the Low Concentration of Intestinal Secretory Immunoglobulin A in a Weanling Mouse Model of Wasting Protein-Energy Malnutrition
J. Nutr., March 1, 1997; 127(3): 427 - 435.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. Schweizer, P. D. Stahl, and J. Rohrer
A Di-aromatic Motif in the Cytosolic Tail of the Mannose Receptor Mediates Endosomal Sorting
J. Biol. Chem., September 15, 2000; 275(38): 29694 - 29700.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.