The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, H. T.
Right arrow Articles by Krensky, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, H. T.
Right arrow Articles by Krensky, A. M.

The Journal of Immunology, Vol 154, Issue 4 1614-1623, Copyright © 1995 by American Association of Immunologists

ARTICLES

Gamma delta T cell recognition of tumor Ig peptide

HT Kim, EL Nelson, C Clayberger, M Sanjanwala, J Sklar and AM Krensky
Department of Pediatrics, Stanford University School of Medicine, CA 94305.

Although gamma delta T cells have been postulated to act as a surveillance mechanism that eliminates transformed or otherwise damaged cells, little is known about tumor recognition by gamma delta T cells, including the Ags that are recognized and the molecules that present them. Previously, we described human gamma delta CTL that recognize the autologous B cell lymphoma. Here we report that these gamma delta CTL lyse heterologous cells transfected with the tumor Ig lambda chain gene. Furthermore, the lambda chain is recognized as processed peptide in an Id-specific manner. T cell recognition does not involve classical MHC molecules, but it could be blocked by Abs directed against the heat shock protein grp75. These findings show a specific gamma delta T cell response to a highly polymorphic Ag such as tumor Id and implicate heat shock protein as a molecule required for recognition.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
L. Hviid, J. A. L. Kurtzhals, V. Adabayeri, S. Loizon, K. Kemp, B. Q. Goka, A. Lim, O. Mercereau-Puijalon, B. D. Akanmori, and C. Behr
Perturbation and Proinflammatory Type Activation of V{delta}1+ {gamma}{delta} T Cells in African Children with Plasmodium falciparum Malaria
Infect. Immun., May 1, 2001; 69(5): 3190 - 3196.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. T. Cady, M. Lahn, M. Vollmer, M. Tsuji, S. J. Seo, C. L. Reardon, R. L. O'Brien, and W. K. Born
Response of Murine {gamma}{delta} T Cells to the Synthetic Polypeptide Poly-Glu50Tyr50 1
J. Immunol., August 15, 2000; 165(4): 1790 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
U. Zugel and S. H. E. Kaufmann
Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases
Clin. Microbiol. Rev., January 1, 1999; 12(1): 19 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Seo, Y. Tokura, F. Furukawa, and M. Takigawa
Down-Regulation of Tumoricidal NK and NK T Cell Activities by MHC Kb Molecules Expressed on Th2-Type {gamma}{delta} T and {alpha}{beta} T Cells Coinfiltrating in Early B16 Melanoma Lesions
J. Immunol., October 15, 1998; 161(8): 4138 - 4145.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.