The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by del Guercio, M. F.
Right arrow Articles by Sette, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by del Guercio, M. F.
Right arrow Articles by Sette, A.

The Journal of Immunology, Vol 154, Issue 2 685-693, Copyright © 1995 by American Association of Immunologists

ARTICLES

Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype

MF del Guercio, J Sidney, G Hermanson, C Perez, HM Grey, RT Kubo and A Sette
Cytel, San Diego, CA 92121.

Direct MHC binding assays with radiolabeled peptides and HLA class I- expressing mammalian cells such as EBV-transformed B cell lines and PHA- activated blasts have been developed. Significant binding of the radiolabeled probe could be obtained if the target cells were preincubated overnight at 26 degrees C in the presence of beta 2- microglobulin. Under these conditions, up to a few percent of the HLA molecules expressed by either cell type could be bound by the labeled peptides. With these assays, the degree of cross-reactivity of the A*0201-restricted hepatitis B virus core 18-27 peptide with other A2 subtypes was examined. It was determined that this peptide epitope also binds the A*0202, A*0205, and A*0206 but not A*0207 subtypes. Inhibition experiments with panels of synthetic peptide analogues underlined the similar ligand specificities of the HLA-A*0201, A*0202, and A*0205 alleles. Analysis of the polymorphic residues that help form the B and F pockets of various HLA alleles allowed prediction of binding of the hepatitis B virus core 18-27 epitope to two other HLA alleles (HLA-A*6802 and A*6901). Thus, it appears that a family of at least six different HLA-A molecules may share overlapping ligand specificities (aliphatic residues in position 2 and at the C termini). These results suggest that broadly cross-reactive peptide epitopes can be identified and greatly enhance the prospective feasibility of peptide-based vaccination approaches.


This article has been cited by other articles:


Home page
 BloodHome page
I. G. Schuster, D. H. Busch, E. Eppinger, E. Kremmer, S. Milosevic, C. Hennard, C. Kuttler, J. W. Ellwart, B. Frankenberger, E. Nossner, et al.
Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies
Blood, October 15, 2007; 110(8): 2931 - 2939.
[Abstract] [Full Text] [PDF]

Home page
 Protein Eng Des SelHome page
Q.-S. Du, Y.-T. Wei, Z.-W. Pang, K.-C. Chou, and R.-B. Huang
Predicting the affinity of epitope-peptides with class I MHC molecule HLA-A*0201: an application of amino acid-based peptide prediction
Protein Eng. Des. Sel., September 1, 2007; 20(9): 417 - 423.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
T. Hertz and C. Yanover
Identifying HLA supertypes by learning distance functions
Bioinformatics, January 15, 2007; 23(2): e148 - e155.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
J. C. Tong, T. W. Tan, and S. Ranganathan
In silico grouping of peptide/HLA class I complexes using structural interaction characteristics
Bioinformatics, January 15, 2007; 23(2): 177 - 183.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. H. Mealey, J.-H. Lee, S. R. Leib, M. H. Littke, and T. C. McGuire
A Single Amino Acid Difference within the {alpha}-2 Domain of Two Naturally Occurring Equine MHC Class I Molecules Alters the Recognition of Gag and Rev Epitopes by Equine Infectious Anemia Virus-Specific CTL
J. Immunol., November 15, 2006; 177(10): 7377 - 7390.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. E. Lyke, R. B. Burges, Y. Cissoko, L. Sangare, A. Kone, M. Dao, I. Diarra, M. A. Fernandez-Vina, C. V. Plowe, O. K. Doumbo, et al.
HLA-A2 Supertype-Restricted Cell-Mediated Immunity by Peripheral Blood Mononuclear Cells Derived from Malian Children with Severe or Uncomplicated Plasmodium falciparum Malaria and Healthy Controls
Infect. Immun., September 1, 2005; 73(9): 5799 - 5808.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. A. Doytchinova and D. R. Flower
In Silico Identification of Supertypes for Class II MHCs
J. Immunol., June 1, 2005; 174(11): 7085 - 7095.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. A. Doytchinova, P. Guan, and D. R. Flower
Identifiying Human MHC Supertypes Using Bioinformatic Methods
J. Immunol., April 1, 2004; 172(7): 4314 - 4323.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. J. Lavender, B. J. Ma, E. T. Silver, and K. P. Kane
The Rat RT1-A1c MHC Molecule Is a Xenogeneic Ligand Recognized by the Mouse Activating Ly-49W and Inhibitory Ly-49G Receptors
J. Immunol., March 15, 2004; 172(6): 3518 - 3526.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Sidney, S. Southwood, V. Pasquetto, and A. Sette
Simultaneous Prediction of Binding Capacity for Multiple Molecules of the HLA B44 Supertype
J. Immunol., December 1, 2003; 171(11): 5964 - 5974.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. C. McGuire, S. R. Leib, R. H. Mealey, D. G. Fraser, and D. J. Prieur
Presentation and Binding Affinity of Equine Infectious Anemia Virus CTL Envelope and Matrix Protein Epitopes by an Expressed Equine Classical MHC Class I Molecule
J. Immunol., August 15, 2003; 171(4): 1984 - 1993.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. R. Burrows, R. A. Elkington, J. J. Miles, K. J. Green, S. Walker, S. M. Haryana, D. J. Moss, H. Dunckley, J. M. Burrows, and R. Khanna
Promiscuous CTL Recognition of Viral Epitopes on Multiple Human Leukocyte Antigens: Biological Validation of the Proposed HLA A24 Supertype
J. Immunol., August 1, 2003; 171(3): 1407 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D.-G. Lim, J. M. Slavik, K. Bourcier, K. J. Smith, and D. A. Hafler
Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function
J. Exp. Med., July 7, 2003; 198(1): 99 - 109.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Jaye, C. A. Herberts, S. Jallow, S. Atabani, M. R. Klein, P. Hoogerhout, M. Kidd, C. A. C. M. van Els, and H. C. Whittle
Vigorous but Short-Term Gamma Interferon T-Cell Responses against a Dominant HLA-A*02-Restricted Measles Virus Epitope in Patients with Measles
J. Virol., April 15, 2003; 77(8): 5014 - 5016.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. A. Castelli, C. Buhot, A. Sanson, H. Zarour, S. Pouvelle-Moratille, C. Nonn, H. Gahery-Segard, J.-G. Guillet, A. Menez, B. Georges, et al.
HLA-DP4, the Most Frequent HLA II Molecule, Defines a New Supertype of Peptide-Binding Specificity
J. Immunol., December 15, 2002; 169(12): 6928 - 6934.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. S. Mitchell, D. Darrah, D. Yeung, S. Halpern, A. Wallace, J. Voland, V. Jones, and J. Kan-Mitchell
Phase I Trial of Adoptive Immunotherapy With Cytolytic T Lymphocytes Immunized Against a Tyrosinase Epitope
J. Clin. Oncol., February 15, 2002; 20(4): 1075 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Keogh, J. Fikes, S. Southwood, E. Celis, R. Chesnut, and A. Sette
Identification of New Epitopes from Four Different Tumor-Associated Antigens: Recognition of Naturally Processed Epitopes Correlates with HLA-A*0201-Binding Affinity
J. Immunol., July 15, 2001; 167(2): 787 - 796.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. H. Barouch, A. Craiu, S. Santra, M. A. Egan, J. E. Schmitz, M. J. Kuroda, T.-M. Fu, J.-H. Nam, L. S. Wyatt, M. A. Lifton, et al.
Elicitation of High-Frequency Cytotoxic T-Lymphocyte Responses against both Dominant and Subdominant Simian-Human Immunodeficiency Virus Epitopes by DNA Vaccination of Rhesus Monkeys
J. Virol., March 1, 2001; 75(5): 2462 - 2467.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. A. Urvater, H. Hickman, J. L. Dzuris, K. Prilliman, T. M. Allen, K. J. Schwartz, D. Lorentzen, C. Shufflebotham, E. J. Collins, D. L. Neiffer, et al.
Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2
J. Immunol., March 1, 2001; 166(5): 3334 - 3344.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. S. Mitchell, J. Kan-Mitchell, B. Minev, C. Edman, and R. J. Deans
A Novel Melanoma Gene (MG50) Encoding the Interleukin 1 Receptor Antagonist and Six Epitopes Recognized by Human Cytolytic T Lymphocytes
Cancer Res., November 1, 2000; 60(22): 6448 - 6456.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, et al.
Identification of Dominant Optimal HLA-B60- and HLA-B61-Restricted Cytotoxic T-Lymphocyte (CTL) Epitopes: Rapid Characterization of CTL Responses by Enzyme-Linked Immunospot Assay
J. Virol., September 15, 2000; 74(18): 8541 - 8549.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. L. Dzuris, J. Sidney, E. Appella, R. W. Chesnut, D. I. Watkins, and A. Sette
Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques
J. Immunol., January 1, 2000; 164(1): 283 - 291.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. I. Nishimura, D. Avichezer, M. C. Custer, C. S. Lee, C. Chen, M. R. Parkhurst, R. A. Diamond, P. F. Robbins, D. J. Schwartzentruber, and S. A. Rosenberg
MHC Class I-restricted Recognition of a Melanoma Antigen by a Human CD4+ Tumor Infiltrating Lymphocyte
Cancer Res., December 1, 1999; 59(24): 6230 - 6238.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
A. R. Kammer, S. H. van der Burg, B. Grabscheid, I. P. Hunziker, K. M.C. Kwappenberg, J. Reichen, C. J.M. Melief, and A. Cerny
Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition
J. Exp. Med., July 19, 1999; 190(2): 169 - 176.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. R. Prilliman, K. W. Jackson, M. Lindsey, J. Wang, D. Crawford, and W. H. Hildebrand
HLA-B15 Peptide Ligands Are Preferentially Anchored at Their C Termini
J. Immunol., June 15, 1999; 162(12): 7277 - 7284.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Scognamiglio, D. Accapezzato, M. A. Casciaro, A. Cacciani, M. Artini, G. Bruno, M. L. Chircu, J. Sidney, S. Southwood, S. Abrignani, et al.
Presence of Effector CD8+ T Cells in Hepatitis C Virus-Exposed Healthy Seronegative Donors
J. Immunol., June 1, 1999; 162(11): 6681 - 6689.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. T. Evans, L. A. Knapp, P. Jing, M. S. Piekarczyk, V. S. Hinshaw, and D. I. Watkins
Three Different MHC Class I Molecules Bind the Same CTL Epitope of the Influenza Virus in a Primate Species with Limited MHC Class I Diversity
J. Immunol., April 1, 1999; 162(7): 3970 - 3977.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. D. Livingston, J. Alexander, C. Crimi, C. Oseroff, E. Celis, K. Daly, L. G. Guidotti, F. V. Chisari, J. Fikes, R. W. Chesnut, et al.
Altered Helper T Lymphocyte Function Associated with Chronic Hepatitis B Virus Infection and its Role in Response to Therapeutic Vaccination in Humans
J. Immunol., March 1, 1999; 162(5): 3088 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Shields, R. Kubota, W. Hodgson, S. Jacobson, W. E. Biddison, and R. K. Ribaudo
The Effect of Human beta 2-Microglobulin on Major Histocompatibility Complex I Peptide Loading and the Engineering of a High Affinity Variant. IMPLICATIONS FOR PEPTIDE-BASED VACCINES
J. Biol. Chem., October 23, 1998; 273(43): 28010 - 28018.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Bertoni, A. Sette, J. Sidney, L. G. Guidotti, M. Shapiro, R. Purcell, and F. V. Chisari
Human Class I Supertypes and CTL Repertoires Extend to Chimpanzees
J. Immunol., October 15, 1998; 161(8): 4447 - 4455.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Maruya, H. Saji, S. Seki, Y. Fujii, K. Kato, S. Kai, A. Hiraoka, K. Kawa, Y. Hoshi, K. Ito, et al.
Evidence That CD31, CD49b, and CD62L Are Immunodominant Minor Histocompatibility Antigens in HLA Identical Sibling Bone Marrow Transplants
Blood, September 15, 1998; 92(6): 2169 - 2176.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Bettinotti, C. J. Kim, K.-H. Lee, M. Roden, J. N. Cormier, M. Panelli, K. K. Parker, and F. M. Marincola
Stringent Allele/Epitope Requirements for MART-1/Melan A Immunodominance: Implications for Peptide-Based Immunotherapy
J. Immunol., July 15, 1998; 161(2): 877 - 889.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. M. Allen, J. Sidney, M.-F. del Guercio, R. L. Glickman, G. L. Lensmeyer, D. A. Wiebe, R. DeMars, C. D. Pauza, R. P. Johnson, A. Sette, et al.
Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus
J. Immunol., June 15, 1998; 160(12): 6062 - 6071.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Southwood, J. Sidney, A. Kondo, M.-F. del Guercio, E. Appella, S. Hoffman, R. T. Kubo, R. W. Chesnut, H. M. Grey, and A. Sette
Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires
J. Immunol., April 1, 1998; 160(7): 3363 - 3373.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. K. H. Wong, D. D. Dudley, N. H. Afdhal, J. Dienstag, C. M. Rice, L. Wang, M. Houghton, B. D. Walker, and M. J. Koziel
Liver-Derived CTL in Hepatitis C Virus Infection: Breadth and Specificity of Responses in a Cohort of Persons with Chronic Infection
J. Immunol., February 1, 1998; 160(3): 1479 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. J. Diamond, J. York, J.-Y. Sun, C. L. Wright, and S. J. Forman
Development of a Candidate HLA A*0201 Restricted Peptide-Based Vaccine Against Human Cytomegalovirus Infection
Blood, September 1, 1997; 90(5): 1751 - 1767.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. F. Luescher, P. Romero, D. Kuznetsov, D. Rimoldi, P. Coulie, J.-C. Cerottini, and C. V. Jongeneel
HLA Photoaffinity Labeling Reveals Overlapping Binding of Homologous Melanoma-associated Gene Peptides by HLA-A1, HLA-A29, and HLA-B44
J. Biol. Chem., May 24, 1996; 271(21): 12463 - 12471.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.