| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 154, Issue 11 5649-5655, Copyright © 1995 by American Association of Immunologists
ARTICLES |
P Garside, M Steel, EA Worthey, A Satoskar, J Alexander, H Bluethmann, FY Liew and AM Mowat
Department of Immunology, Western Infirmary, University of Glasgow, Scotland.
Oral administration of aqueous protein Ag results in profound immunologic tolerance, and it has been suggested previously that this reflects selective activation of Th subsets. Here we show that the induction of oral tolerance by feeding a single high dose of OVA to mice significantly reduces the production of both Th1- and Th2- dependent cytokines and is accompanied by a marked reduction of specific Abs of both the IgG2a and IgG1 isotypes in vivo. Oral tolerance was also induced normally in IL-4-deficient mice. These results indicate that both subsets of the Th cell are equally susceptible to the induction of tolerance with a single high dose of Ag delivered via the oral route and that this phenomenon does not require Th2 cells.
This article has been cited by other articles:
|
|
 |
|
  W.-Q. Lai, H. H. Goh, Z. Bao, W. S. F. Wong, A. J. Melendez, and B. P. Leung The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma J. Immunol., March 15, 2008; 180(6): 4323 - 4329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Safadi, C. E. Alvarez, M. Ohta, J. Brimnes, T. Kraus, W. Mehal, J. Bromberg, L. Mayer, and S. L. Friedman Enhanced Oral Tolerance in Transgenic Mice with Hepatocyte Secretion of IL-10 J. Immunol., September 15, 2005; 175(6): 3577 - 3583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Duan, J. H. P. Chan, C. H. Wong, B. P. Leung, and W. S. F. Wong Anti-Inflammatory Effects of Mitogen-Activated Protein Kinase Kinase Inhibitor U0126 in an Asthma Mouse Model J. Immunol., June 1, 2004; 172(11): 7053 - 7059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McKay, B. P. Leung, I. B. McInnes, N. C. Thomson, and F. Y. Liew A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma J. Immunol., March 1, 2004; 172(5): 2903 - 2908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. T. Tobagus, W. R. Thomas, and P. G. Holt Adjuvant Costimulation during Secondary Antigen Challenge Directs Qualitative Aspects of Oral Tolerance Induction, Particularly during the Neonatal Period J. Immunol., February 15, 2004; 172(4): 2274 - 2285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kaji, S. Hachimura, W. Ise, and S. Kaminogawa Proteome Analysis Reveals Caspase Activation in Hyporesponsive CD4 T Lymphocytes Induced in Vivo by the Oral Administration of Antigen J. Biol. Chem., July 18, 2003; 278(30): 27836 - 27843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Beacock-Sharp, A. M. Donachie, N. C. Robson, and A. M. Mowat A role for dendritic cells in the priming of antigen-specific CD4+ and CD8+ T lymphocytes by immune-stimulating complexes in vivo Int. Immunol., June 1, 2003; 15(6): 711 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Tsuji, K. Mizumachi, and J.-i. Kurisaki Antigen-specific, CD4+CD25+ regulatory T cell clones induced in Peyer's patches Int. Immunol., April 1, 2003; 15(4): 525 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Gonnella, D. Kodali, and H. L. Weiner Induction of Low Dose Oral Tolerance in Monocyte Chemoattractant Protein-1- and CCR2-Deficient Mice J. Immunol., March 1, 2003; 170(5): 2316 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Williamson, J. M. Bilsborough, and J. L. Viney Regulation of Mucosal Dendritic Cell Function by Receptor Activator of NF-{kappa}B (RANK)/RANK Ligand Interactions: Impact on Tolerance Induction J. Immunol., October 1, 2002; 169(7): 3606 - 3612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Smith, F. McAskill, and P. Garside Orally Tolerized T Cells Are Only Able to Enter B Cell Follicles Following Challenge with Antigen in Adjuvant, but They Remain Unable to Provide B Cell Help J. Immunol., May 1, 2002; 168(9): 4318 - 4325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. F. Melo, J. Qian, M. El-Amine, R. K. Agarwal, N. Soukhareva, Y. Kang, and D. W. Scott Gene Transfer of Ig-Fusion Proteins Into B Cells Prevents and Treats Autoimmune Diseases J. Immunol., May 1, 2002; 168(9): 4788 - 4795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yoshino, H. Hayashi, S. Taneda, H. Takano, M. Sagai, and Y. Mori Effect of Diesel Exhaust Particle Extracts on Induction of Oral Tolerance in Mice Toxicol. Sci., April 1, 2002; 66(2): 293 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. I. Mowat, A. M. Donachie, S. Jagewall, K. Schon, B. Lowenadler, K. Dalsgaard, P. Kaastrup, and N. Lycke CTA1-DD-Immune Stimulating Complexes: a Novel, Rationally Designed Combined Mucosal Vaccine Adjuvant Effective with Nanogram Doses of Antigen J. Immunol., September 15, 2001; 167(6): 3398 - 3405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cohn Food for Thought . Can Immunological Tolerance Be Induced to Treat Asthma? Am. J. Respir. Cell Mol. Biol., May 1, 2001; 24(5): 509 - 512. [Full Text]
|
|
|
|
|
|
O. Alpan, G. Rudomen, and P. Matzinger The Role of Dendritic Cells, B Cells, and M Cells in Gut-Oriented Immune Responses J. Immunol., April 15, 2001; 166(8): 4843 - 4852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lombardi, P. J. Dunne, D. Scheel-Toellner, T. Sanyal, D. Pilling, L. S. Taams, P. Life, J. M. Lord, M. Salmon, and A. N. Akbar Type 1 IFN Maintains the Survival of Anergic CD4+ T Cells J. Immunol., October 1, 2000; 165(7): 3782 - 3789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. SMITH, A. D. EATON, L. M. FINLAYSON, and P. GARSIDE Oral Tolerance Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): S175 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Desvignes, N. Etchart, J. Kehren, I. Akiba, J.-F. Nicolas, and D. Kaiserlian Oral Administration of Hapten Inhibits In Vivo Induction of Specific Cytotoxic CD8+ T Cells Mediating Tissue Inflammation: A Role for Regulatory CD4+ T Cells J. Immunol., March 1, 2000; 164(5): 2515 - 2522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujihashi, T. Dohi, M.-N. Kweon, J. R. Mcghee, T. Koga, M. D. Cooper, S. Tonegawa, and H. Kiyono {gamma}{delta}T cells regulate mucosally induced tolerance in a dose-dependent fashion Int. Immunol., December 1, 1999; 11(12): 1907 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McI. Mowat, M. Steel, A. J. Leishman, and P. Garside Normal Induction of Oral Tolerance in the Absence of a Functional IL-12-Dependent IFN-{gamma} Signaling Pathway J. Immunol., November 1, 1999; 163(9): 4728 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Williamson, G. M. Westrich, and J. L. Viney Modulating Dendritic Cells to Optimize Mucosal Immunization Protocols J. Immunol., October 1, 1999; 163(7): 3668 - 3675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Shi, M. J. Grusby, and C. Nagler-Anderson Orally Induced Peripheral Nonresponsiveness Is Maintained in the Absence of Functional Th1 or Th2 Cells J. Immunol., May 1, 1999; 162(9): 5143 - 5148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. Rizzo, R. A. Morawetz, N. E. Miller-Rivero, R. Choi, B. Wiggert, C.-C. Chan, H. C. Morse III, R. B. Nussenblatt, and R. R. Caspi IL-4 and IL-10 Are Both Required for the Induction of Oral Tolerance J. Immunol., March 1, 1999; 162(5): 2613 - 2622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P GARSIDE, A M. MOWAT, and A KHORUTS Oral tolerance in disease Gut, January 1, 1999; 44(1): 137 - 142. [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. ROSSINI, D. L. GREINER, and J. P. MORDES Induction of Immunologic Tolerance for Transplantation Physiol Rev, January 1, 1999; 79(1): 99 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Blank, J. George, V. Barak, A. Tincani, T. Koike, and Y. Shoenfeld Oral Tolerance to Low Dose {beta}2-Glycoprotein I: Immunomodulation of Experimental Antiphospholipid Syndrome J. Immunol., November 15, 1998; 161(10): 5303 - 5312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yoshino, M. Ohsawa, and M. Sagai Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice J. Pharmacol. Exp. Ther., November 1, 1998; 287(2): 679 - 683. [Abstract] [Full Text]
|
|
|
|
|
|
K. S. Barone, D. D. Tolarova, I. Ormsby, T. Doetschman, and J. G. Michael Induction of Oral Tolerance in TGF-{beta}1 Null Mice J. Immunol., July 1, 1998; 161(1): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Viney, A. M. Mowat, J. M. O'Malley, E. Williamson, and N. A. Fanger Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance J. Immunol., June 15, 1998; 160(12): 5815 - 5825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Karpus, K. J. Kennedy, S. L. Kunkel, and N. W. Lukacs Monocyte Chemotactic Protein 1 Regulates Oral Tolerance Induction by Inhibition of T Helper Cell 1-related Cytokines J. Exp. Med., March 2, 1998; 187(5): 733 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Shi, C. J. Ingui, I. Dodge, and C. Nagler-Anderson A Helminth-Induced Mucosal Th2 Response Alters Nonresponsiveness to Oral Administration of a Soluble Antigen J. Immunol., March 1, 1998; 160(5): 2449 - 2455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-N. Kweon, K. Fujihashi, J. L. VanCott, K. Higuchi, M. Yamamoto, J. R. McGhee, and H. Kiyono Lack of Orally Induced Systemic Unresponsiveness in IFN-{gamma} Knockout Mice J. Immunol., February 15, 1998; 160(4): 1687 - 1693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Grdic, E. Hornquist, M. Kjerrulf, and N. Y. Lycke Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8+ T Cells in the Normal Gut Mucosa J. Immunol., January 15, 1998; 160(2): 754 - 762. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
