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The Journal of Immunology, Vol 154, Issue 10 5103-5113, Copyright © 1995 by American Association of Immunologists
ARTICLES |
C Penit, B Lucas and F Vasseur
INSERM U345, Necker Institute, Medical Faculty, Necker-Enfants Malades (Rene Descartes University), Paris, France.
T cell early precursors belong to the CD3-CD4-CD8- triple negative (TN) thymocyte population that can be subdivided on the basis of CD44, CD25, and heat-stable Ag (HSA) expression. The kinetics and precursor product relationships of these subsets, as well as of the CD4/8low intermediates, were studied by using pulse labeling with bromodeoxyuridine (BrdUrd). The highest frequencies of DNA-synthesizing cells were found in CD44+CD25+ and CD44-CD25low or CD25- subsets. The major TN cell type (CD44-CD25high), as well as CD44+ CD25-HSAlow early precursors, contained a majority of resting cells. RAG-2-/- mice contained less cells in DNA synthesis than normal mice, and CD44-CD25- /low cells were absent. In female mice transgenic for the anti-HYTCR, CD44-CD25high cells were almost all cycling, but a high percentage of resting cells was found in CD44-CD25- cells. In days following the BrdUrd pulse, there was a reduction in the number of BrdUrd+ cells in most subsets, with the exception of the labeled CD44-CD25high cells that showed a bell-shaped curve. The kinetics and cell size evolution suggest that the majority of these cells do not give rise to CD4+CD8+ cells. In RAG-2-/- cells, the block at the CD44-CD25high stage involved all cells. In TCR transgenic (Tg) mice, no block was seen at the CD44- CD25high stage, suggesting that early expression of a complete TCR receptor precludes the normal selection step. However, another block in the differentiation process was observed at the CD44-CD25- step in TCR Tg mice, suggesting an additional selection point.
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J. Buer, I. Aifantis, J. P. DiSanto, H. J. Fehling, and H. v. Boehmer Role of Different T Cell Receptors in the Development of Pre-T Cells J. Exp. Med., May 5, 1997; 185(9): 1541 - 1548. [Abstract] [Full Text] [PDF]
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Y. Yasuda, I. Nishijima, S. Watanabe, K.-i. Arai, A. Zlotnik, and T. A. Moore Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Induces Inhibition of Intrathymic T-Cell Development in hGM-CSF Receptor Transgenic Mice Blood, February 15, 1997; 89(4): 1349 - 1356. [Abstract] [Full Text] [PDF]
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I. Falk, J. Biro, H. Kohler, and K. Eichmann Proliferation Kinetics Associated with T Cell Receptor-{beta} Chain Selection of Fetal Murine Thymocytes J. Exp. Med., December 1, 1996; 184(6): 2327 - 2340. [Abstract] [Full Text] [PDF]
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E S Hoffman, L Passoni, T Crompton, T M Leu, D G Schatz, A Koff, M J Owen, and A C Hayday Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes & Dev., April 15, 1996; 10(8): 948 - 962. [Abstract] [PDF]
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C. Lancrin, E. Schneider, F. Lambolez, M.-L. Arcangeli, C. Garcia-Cordier, B. Rocha, and S. Ezine Major T Cell Progenitor Activity in Bone Marrow-derived Spleen Colonies J. Exp. Med., April 1, 2002; 195(7): 919 - 929. [Abstract] [Full Text] [PDF]
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