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The Journal of Immunology, Vol 154, Issue 1 299-307, Copyright © 1995 by American Association of Immunologists
ARTICLES |
ME Berman and WA Muller
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.
Platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) is a member of the Ig gene superfamily expressed on the surfaces of monocytes (Mo), neutrophils (PMN), and some T cell subsets, as well as on platelets and the intercellular junctions of endothelial cells. We used mAbs (mAb) against PECAM on Mo and PMN to mimic interaction with natural ligand. Such treatment resulted in the rapid increase of leukocyte beta 2 integrin-mediated adhesive function, as measured in two in vitro assays. Anti-PECAM-treated Mo bound more rapidly and in a CD18-dependent manner to cultured endothelial cells. Monovalent Fab fragments augmented binding significantly and intact IgG, bivalent F(ab')2 fragments, and secondarily cross-linked Fab fragments were even more effective. In a direct assay of CD11b/CD18 (CR3) function, PMN settling on surfaces coated with anti-PECAM mAb (including Fab fragments) were stimulated to bind C3bi-coated erythrocytes. These studies demonstrate that, in addition to the previously described functions of PECAM-1, this molecule is capable of participating in an adhesion cascade resulting in the activation of Mo and PMN beta 2 integrins. This activation may be important for the CR3-dependent adhesion events that are critical in the emigration of Mo and PMN at sites of inflammation.
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N. Sheibani and W. A. Frazier Down-Regulation of Platelet Endothelial Cell Adhesion Molecule-1 Results in Thrombospondin-1 Expression and Concerted Regulation of Endothelial Cell Phenotype Mol. Biol. Cell, April 1, 1998; 9(4): 701 - 713. [Abstract] [Full Text]
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D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets Blood, January 15, 1998; 91(2): 500 - 507. [Abstract] [Full Text] [PDF]
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K. Sagawa, T. Kimura, M. Swieter, and R. P. Siraganian The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31) J. Biol. Chem., December 5, 1997; 272(49): 31086 - 31091. [Abstract] [Full Text] [PDF]
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M. Litwin, K. Clark, L. Noack, J. Furze, M. Berndt, S. Albelda, M. Vadas, and J. Gamble Novel Cytokine-independent Induction of Endothelial Adhesion Molecules Regulated by Platelet/Endothelial Cell Adhesion Molecule (CD31) J. Cell Biol., October 6, 1997; 139(1): 219 - 228. [Abstract] [Full Text] [PDF]
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D. E. Jackson, K. R. Kupcho, and Peter. J. Newman Characterization of Phosphotyrosine Binding Motifs in the Cytoplasmic Domain of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Are Required for the Cellular Association and Activation of the Protein-tyrosine Phosphatase, SHP-2 J. Biol. Chem., October 3, 1997; 272(40): 24868 - 24875. [Abstract] [Full Text] [PDF]
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J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity J. Cell Biol., September 22, 1997; 138(6): 1425 - 1435. [Abstract] [Full Text] [PDF]
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K. Sagawa, W. Swaim, J. Zhang, E. Unsworth, and R. P. Siraganian Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31) J. Biol. Chem., May 16, 1997; 272(20): 13412 - 13418. [Abstract] [Full Text] [PDF]
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F. Liao, J. Ali, T. Greene, and W. A. Muller Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo J. Exp. Med., April 7, 1997; 185(7): 1349 - 1358. [Abstract] [Full Text] [PDF]
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D. E. Jackson, C. M. Ward, R. Wang, and P. J. Newman The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING J. Biol. Chem., March 14, 1997; 272(11): 6986 - 6993. [Abstract] [Full Text] [PDF]
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R. J. Gumina, N. E. Kirschbaum, K. Piotrowski, and P. J. Newman Characterization of the Human Platelet/Endothelial Cell Adhesion Molecule-1 Promoter: Identification of a GATA-2 Binding Element Required for Optimal Transcriptional Activity Blood, February 15, 1997; 89(4): 1260 - 1269. [Abstract] [Full Text] [PDF]
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J. Sun, J. Williams, H.-C. Yan, K. M. Amin, S. M. Albelda, and H. M. DeLisser Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1and 2and Depends on the Cytoplasmic Domain and the Level of Surface Expression J. Biol. Chem., August 2, 1996; 271(31): 18561 - 18570. [Abstract] [Full Text] [PDF]
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Q.-H. Sun, H. M. DeLisser, M. M. Zukowski, C. Paddock, S. M. Albelda, and P. J. Newman Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity J. Biol. Chem., May 10, 1996; 271(19): 11090 - 11098. [Abstract] [Full Text] [PDF]
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C. Buckley, R Doyonnas, J. Newton, S. Blystone, E. Brown, S. Watt, and D. Simmons Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1 J. Cell Sci., January 2, 1996; 109(2): 437 - 445. [Abstract] [PDF]
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H.-C. Yan, H. S. Baldwin, J. Sun, C. A. Buck, S. M. Albelda, and H. M. DeLisser Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) J. Biol. Chem., October 6, 1995; 270(40): 23672 - 23680. [Abstract] [Full Text] [PDF]
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 G. Cao, C. D. O'Brien, Z. Zhou, S. M. Sanders, J. N. Greenbaum, A. Makrigiannakis, and H. M. DeLisser Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1181 - C1190. [Abstract] [Full Text] [PDF]
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