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The Journal of Immunology, Vol 153, Issue 6 2568-2578, Copyright © 1994 by American Association of Immunologists

ARTICLES

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages

S Xu, A Cooper, S Sturgill-Koszycki, T van Heyningen, D Chatterjee, I Orme, P Allen and DG Russell
Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110.

Despite the potential role of the macrophage in the eradication of invading microbes, Mycobacterium species have evolved mechanisms to ensure their survival and replication inside the macrophage. Particles phagocytosed by macrophages normally will be delivered into acid lysosomal compartments for degradation. Mycobacterium must, in some way, avoid this fate by modulation of their phagosome. Immunoelectron microscopy of macrophages infected with Mycobacterium avium or Mycobacterium tuberculosis indicates that the vacuolar membrane surrounding the bacilli possesses the late endosomal/lysosomal marker, LAMP-1 (lysosomal-associated membrane protein-1), but lacks the vesicular proton-ATPase. Analysis of the intersection of the bacteria- containing vacuoles with the endocytic network of the macrophage supports previous studies indicating that these bacilli restrict the fusion capability of their intracellular compartments. The occurrence of vesicles containing lipoarabinomannan, discrete from those containing Mycobacterium, indicate that material does traffic out from the mycobacterial vacuole. To compensate for this loss of membrane, the vacuole must remain dynamic and fuse with LAMP-1-containing vesicles to maintain the density of this marker.


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A. Pashine, B. John, S. Rath, A. George, and V. Bal
Th1 dominance in the immune response to live Salmonella typhimurium requires bacterial invasiveness but not persistence
Int. Immunol., April 1, 1999; 11(4): 481 - 489.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
C. Manca, S. Paul, C. E. Barry III, V. H. Freedman, and G. Kaplan
Mycobacterium tuberculosis Catalase and Peroxidase Activities and Resistance to Oxidative Killing in Human Monocytes In Vitro
Infect. Immun., January 1, 1999; 67(1): 74 - 79.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Z. Hmama, R. Gabathuler, W. A. Jefferies, G. de Jong, and N. E. Reiner
Attenuation of HLA-DR Expression by Mononuclear Phagocytes Infected with Mycobacterium tuberculosis Is Related to Intracellular Sequestration of Immature Class II Heterodimers
J. Immunol., November 1, 1998; 161(9): 4882 - 4893.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
E.-N. N'Diaye, X. Darzacq, C. Astarie-Dequeker, M. Daffe, J. Calafat, and I. Maridonneau-Parini
Fusion of Azurophil Granules with Phagosomes and Activation of the Tyrosine Kinase Hck Are Specifically Inhibited During Phagocytosis of Mycobacteria by Human Neutrophils
J. Immunol., November 1, 1998; 161(9): 4983 - 4991.
[Abstract] [Full Text] [PDF]

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 J. Bacteriol.Home page
E. Pagán-Ramos, J. Song, M. McFalone, M. H. Mudd, and V. Deretic
Oxidative Stress Response and Characterization of the oxyR-ahpC and furA-katG Loci in Mycobacterium marinum
J. Bacteriol., September 15, 1998; 180(18): 4856 - 4864.
[Abstract] [Full Text]

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 Infect. Immun.Home page
S. Ragno, I. Estrada-Garcia, R. Butler, and M. J. Colston
Regulation of Macrophage Gene Expression by Mycobacterium tuberculosis: Down-Regulation of Mitochondrial Cytochrome c Oxidase
Infect. Immun., August 1, 1998; 66(8): 3952 - 3958.
[Abstract] [Full Text] [PDF]

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 Appl. Environ. Microbiol.Home page
M. Steinert, K. Birkness, E. White, B. Fields, and F. Quinn
Mycobacterium avium Bacilli Grow Saprozoically in Coculture with Acanthamoeba polyphaga and Survive within Cyst Walls
Appl. Envir. Microbiol., June 1, 1998; 64(6): 2256 - 2261.
[Abstract] [Full Text]

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 Infect. Immun.Home page
B. K. Kang and L. S. Schlesinger
Characterization of Mannose Receptor-Dependent Phagocytosis Mediated by Mycobacterium tuberculosis Lipoarabinomannan
Infect. Immun., June 1, 1998; 66(6): 2769 - 2777.
[Abstract] [Full Text] [PDF]

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 JEMHome page
D. M. Lewinsohn, M. R. Alderson, A. L. Briden, S. R. Riddell, S. G. Reed, and K. H. Grabstein
Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis-infected Antigen-presenting Cells
J. Exp. Med., May 18, 1998; 187(10): 1633 - 1640.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. Hess, D. Miko, A. Catic, V. Lehmensiek, D. G. Russell, and S. H. E. Kaufmann
Mycobacterium bovis bacille Calmette-Guerin strains secreting listeriolysin of Listeria monocytogenes
PNAS, April 28, 1998; 95(9): 5299 - 5304.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
J. D. Ernst
Macrophage Receptors for Mycobacterium tuberculosis
Infect. Immun., April 1, 1998; 66(4): 1277 - 1281.
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 J. Immunol.Home page
U. E. Schaible, S. Sturgill-Koszycki, P. H. Schlesinger, and D. G. Russell
Cytokine Activation Leads to Acidification and Increases Maturation of Mycobacterium avium-Containing Phagosomes in Murine Macrophages
J. Immunol., February 1, 1998; 160(3): 1290 - 1296.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
L. Via, R. Fratti, M McFalone, E Pagan-Ramos, D Deretic, and V Deretic
Effects of cytokines on mycobacterial phagosome maturation
J. Cell Sci., January 4, 1998; 111(7): 897 - 905.
[Abstract] [PDF]

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 Infect. Immun.Home page
J. Bernardo, A. M. Billingslea, R. L. Blumenthal, K. F. Seetoo, E. R. Simons, and M. J. Fenton
Differential Responses of Human Mononuclear Phagocytes to Mycobacterial Lipoarabinomannans: Role of CD14 and the Mannose Receptor
Infect. Immun., January 1, 1998; 66(1): 28 - 35.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
K. N. Balaji and W. H. Boom
Processing of Mycobacterium tuberculosis Bacilli by Human Monocytes for CD4+ alpha beta and gamma delta T Cells: Role of Particulate Antigen
Infect. Immun., January 1, 1998; 66(1): 98 - 106.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. J. Hackam, O. D. Rotstein, W.-J. Zhang, N. Demaurex, M. Woodside, O. Tsai, and S. Grinstein
Regulation of Phagosomal Acidification. DIFFERENTIAL TARGETING OF Na+/H+ EXCHANGERS, Na+/K+-ATPases, AND VACUOLAR-TYPE H+-ATPases
J. Biol. Chem., November 21, 1997; 272(47): 29810 - 29820.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. E. Via, D. Deretic, R. J. Ulmer, N. S. Hibler, L. A. Huber, and V. Deretic
Arrest of Mycobacterial Phagosome Maturation Is Caused by a Block in Vesicle Fusion between Stages Controlled by rab5 and rab7
J. Biol. Chem., May 16, 1997; 272(20): 13326 - 13331.
[Abstract] [Full Text] [PDF]

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 JEMHome page
S. Gruenheid, E. Pinner, M. Desjardins, and P. Gros
Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome
J. Exp. Med., February 17, 1997; 185(4): 717 - 730.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
M Desjardins, N. Nzala, R Corsini, and C Rondeau
Maturation of phagosomes is accompanied by changes in their fusion properties and size-selective acquisition of solute materials from endosomes
J. Cell Sci., January 9, 1997; 110(18): 2303 - 2314.
[Abstract] [PDF]

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 ScienceHome page
P. Sieling, D Chatterjee, S. Porcelli, T. Prigozy, R. Mazzaccaro, T Soriano, B. Bloom, M. Brenner, M Kronenberg, P. Brennan, et al.
CD1-restricted T cell recognition of microbial lipoglycan antigens
Science, July 14, 1995; 269(5221): 227 - 230.
[Abstract] [PDF]


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