| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 153, Issue 5 1947-1954, Copyright © 1994 by American Association of Immunologists
ARTICLES |
CM Eischen, CJ Dick and PJ Leibson
Department of Immunology, Mayo Clinic, Rochester, MN 55905.
Selective cell death plays a critical role in the development of the immune repertoire and in the elimination of target cells expressing foreign Ags. The apoptosis induced by ligation of the Fas Ag, a member of the TNFR/nerve growth factor receptor superfamily, contributes to both of these modes of cell loss. However, in spite of the molecular cloning of the Fas Ag and the identification of a specific cytoplasmic domain required for its function, it remains unclear as to which Fas- induced second messengers mediate the development of programmed cell death. We, therefore, evaluated Fas-initiated signal transduction in susceptible cell types. We determined that Fas ligation induces the rapid tyrosine phosphorylation of multiple cellular proteins. These phosphorylation events occur within 1 min and decline toward baseline by 30 min. In addition, Fas ligation increases the in vitro protein kinase activity of the tyrosine phosphorylated proteins. Pharmacologic inhibitors of protein tyrosine kinases block, in a concentration- dependent manner, Fas-induced DNA fragmentation and prolong cell survival. These results suggest that protein tyrosine kinase activation is an early and obligatory signal in Fas-induced apoptosis.
This article has been cited by other articles:
|
|
 |
|
  E. Sharif-Askari, D. Gaucher, R. Halwani, J. Ma, K. Jao, A. Abdallah, E. K. Haddad, and R.-P. Sekaly p56Lck Tyrosine Kinase Enhances the Assembly of Death-inducing Signaling Complex during Fas-mediated Apoptosis J. Biol. Chem., December 7, 2007; 282(49): 36048 - 36056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, S. Shimizu, K. Sakamaki, S. Yonehara, and Y. Tsujimoto A Caspase-8-independent Signaling Pathway Activated by Fas Ligation Leads to Exposure of the Bak N Terminus J. Biol. Chem., August 6, 2004; 279(32): 33865 - 33874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fujita, M. Maruyama, J. Araya, K. Sassa, Y. Kawagishi, R. Hayashi, S. Matsui, T. Kashii, N. Yamashita, E. Sugiyama, et al. Hydrogen Peroxide Induces Upregulation of Fas in Human Airway Epithelial Cells via the Activation of PARP-p53 Pathway Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 542 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gomez-Angelats and J. A. Cidlowski Invited Review: Cell Volume Control and Signal Transduction in Apoptosis Toxicol Pathol, August 1, 2002; 30(5): 541 - 551. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Ungefroren, M.-L. Kruse, A. Trauzold, S. Roeschmann, C. Roeder, A. Arlt, D. Henne-Bruns, and H. Kalthoff FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis J. Cell Sci., January 8, 2001; 114(15): 2735 - 2746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Middleton Jr., C. Kandaswami, and T. C. Theoharides The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer Pharmacol. Rev., December 1, 2000; 52(4): 673 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Gulbins, A. Jekle, K. Ferlinz, H. Grassme, and F. Lang Physiology of apoptosis Am J Physiol Renal Physiol, October 1, 2000; 279(4): F605 - F615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishikawa, Z. Wang, J. Kerns, C. S. Wilcox, and B. I. Carr Inhibition of Hepatoma Cell Growth in Vitro by Arylating and Non-arylating K Vitamin Analogs. SIGNIFICANCE OF PROTEIN TYROSINE PHOSPHATASE INHIBITION J. Biol. Chem., December 3, 1999; 274(49): 34803 - 34810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ruiz-Ruiz, G. Robledo, J. Font, M. Izquierdo, and A. Lopez-Rivas Protein Kinase C Inhibits CD95 (Fas/APO-1)-Mediated Apoptosis by at Least Two Different Mechanisms in Jurkat T Cells J. Immunol., November 1, 1999; 163(9): 4737 - 4746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hensel, R. Hermann, C. Schubert, N. Abe, K. Schmidt, A. Franke, A. Shevchenko, M. Mann, H. K. Muller-Hermelink, and H. P. Vollmers Characterization of Glycosylphosphatidylinositol-linked Molecule CD55/Decay-accelerating Factor as the Receptor for Antibody SC-1-induced Apoptosis Cancer Res., October 1, 1999; 59(20): 5299 - 5306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. SATO, M. G. A. VAN DIXHOORN, F. A. PRINS, A. MOONEY, N. VERHAGEN, Y. MUIZERT, J. SAVILL, L. A. VAN ES, and M. R. DAHA The Terminal Sequence of Complement Plays an Essential Role in Antibody-Mediated Renal Cell Apoptosis J. Am. Soc. Nephrol., June 1, 1999; 10(6): 1242 - 1252. [Abstract] [Full Text]
|
|
|
|
 |
|
 H.-U. Simon, S. Yousefi, B. Dibbert, H. Hebestreit, M. Weber, D. R. Branch, K. Blaser, F. Levi-Schaffer, and G. P. Anderson Role for Tyrosine Phosphorylation and Lyn Tyrosine Kinase in Fas Receptor-Mediated Apoptosis in Eosinophils Blood, July 15, 1998; 92(2): 547 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Szabo, A. Lepple-Wienhues, K. N. Kaba, M. Zoratti, E. Gulbins, and F. Lang Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes PNAS, May 26, 1998; 95(11): 6169 - 6174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ni, Y. Nishikawa, and B. I. Carr Cell Growth Inhibition by a Novel Vitamin K Is Associated with Induction of Protein Tyrosine Phosphorylation J. Biol. Chem., April 17, 1998; 273(16): 9906 - 9911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hebestreit, B. Dibbert, I. Balatti, D. Braun, A. Schapowal, K. Blaser, and H.-U. Simon Disruption of Fas Receptor Signaling by Nitric Oxide in Eosinophils J. Exp. Med., February 2, 1998; 187(3): 415 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ito, R. C. Ribeiro, F. G. Behm, S. C. Raimondi, C.-H. Pui, and D. Campana Cyclosporin A Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia Cells Blood, February 1, 1998; 91(3): 1001 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cuppen, S. Nagata, B. Wieringa, and W. Hendriks No Evidence for Involvement of Mouse Protein-tyrosine Phosphatase-BAS-like Fas-associated Phosphatase-1 in Fas-mediated Apoptosis J. Biol. Chem., November 28, 1997; 272(48): 30215 - 30220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hanada, L. Lin, K. G. Chandy, S. S. Oh, and A. H. Chishti Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56lck Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes J. Biol. Chem., October 24, 1997; 272(43): 26899 - 26904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Brenner, U. Koppenhoefer, C. Weinstock, O. Linderkamp, F. Lang, and E. Gulbins Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153 J. Biol. Chem., August 29, 1997; 272(35): 22173 - 22181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Eischen, T. J. Kottke, L. M. Martins, G. S. Basi, J. S. Tung, W. C. Earnshaw, P. J. Leibson, and S. H. Kaufmann Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions Blood, August 1, 1997; 90(3): 935 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gulbins, I. Szabo, K. Baltzer, and F. Lang Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases PNAS, July 8, 1997; 94(14): 7661 - 7666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Utz, M. Hottelet, P. H. Schur, and P. Anderson Proteins Phosphorylated during Stress-induced Apoptosis Are Common Targets for Autoantibody Production in Patients with Systemic Lupus Erythematosus J. Exp. Med., March 3, 1997; 185(5): 843 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Brown, W. W. Shuford, W.-C. Wang, S. G. Nadler, T. S. Bailey, H. Marquardt, and R. S. Mittler Characterization of a CD43/Leukosialin-mediated Pathway for Inducing Apoptosis in Human T-Lymphoblastoid Cells J. Biol. Chem., November 1, 1996; 271(44): 27686 - 27695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Szabo, E. Gulbins, H. Apfel, X. Zhang, P. Barth, A. E. Busch, K. Schlottmann, O. Pongs, and F. Lang Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation J. Biol. Chem., August 23, 1996; 271(34): 20465 - 20469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J.v. d. Dobbelsteen, C. S. I. Nobel, J. Schlegel, I. A. Cotgreave, S. Orrenius, and A. F.G. Slater Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody J. Biol. Chem., June 28, 1996; 271(26): 15420 - 15427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Orlinick and M. V. Chao Interactions of Cellular Polypeptides with the Cytoplasmic Domain of the Mouse Fas Antigen J. Biol. Chem., April 12, 1996; 271(15): 8627 - 8632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Atkinson, H. Ostergaard, K. Kane, M. J. Pinkoski, A. Caputo, M. W. Olszowy, and R. C. Bleackley A Physical Interaction between the Cell Death Protein Fas and the Tyrosine Kinase p59[IMAGE] J. Biol. Chem., March 15, 1996; 271(11): 5968 - 5971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Sato, S Irie, S Kitada, and J. Reed FAP-1: a protein tyrosine phosphatase that associates with Fas Science, April 21, 1995; 268(5209): 411 - 415. [Abstract] [PDF]
|
|
|
|
|
|
S Nagata and P Golstein The Fas death factor Science, March 10, 1995; 267(5203): 1449 - 1456. [Abstract] [PDF]
|
|
|
|
|
|
Y.-M. Wu, C.-L. Huang, H.-J. Kung, and C.-Y. F. Huang Proteolytic Activation of Etk/Bmx Tyrosine Kinase by Caspases J. Biol. Chem., May 18, 2001; 276(21): 17672 - 17678. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
