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The Journal of Immunology, Vol 153, Issue 2 818-823, Copyright © 1994 by American Association of Immunologists
ARTICLES |
T Bilzer and L Stitz
Institute of Neuropathology, Heinrich Heine University, Dusseldorf, Germany.
Borna disease (BD) is a virus-induced immunopathologic disease of the central nervous system in a variety of species from birds to primates and probably in humans. Severe inflammatory reactions lead to tissue destruction and finally to cortical brain atrophy. After experimental infection of the rat, intraparenchymal CD8+ T cells, MHC class I Ags on Borna disease virus (BDV)-infected neurons, and numerous nerve cell lesions were present. Treatment of BDV-infected rats with the mAb OX-8 directed against CD8+ cells inhibited the immunopathologic reactions and reduced MHC class I Ag expression. Neuronal lesions were minimal and no loss of brain substance could be observed. Because BDV has no acute cytopathic effects, we provide evidence that the presence of CD8+ T cells within the brain parenchyma and the expression of MHC class I Ags on neurons play a major role for immunopathologic brain tissue destruction and virus-infected neurons in vivo can be destroyed by T cell-mediated cytotoxicity.
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E. Furrer, T. Bilzer, L. Stitz, and O. Planz Neutralizing Antibodies in Persistent Borna Disease Virus Infection: Prophylactic Effect of gp94-Specific Monoclonal Antibodies in Preventing Encephalitis J. Virol., January 15, 2001; 75(2): 943 - 951. [Abstract] [Full Text]
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O. Planz and L. Stitz Borna Disease Virus Nucleoprotein (p40) Is a Major Target for CD8+-T-Cell-Mediated Immune Response J. Virol., February 1, 1999; 73(2): 1715 - 1718. [Abstract] [Full Text]
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L. Stitz, K. Noske, O. Planz, E. Furrer, W. I. Lipkin, and T. Bilzer A Functional Role for Neutralizing Antibodies in Borna Disease: Influence on Virus Tropism outside the Central Nervous System J. Virol., November 1, 1998; 72(11): 8884 - 8892. [Abstract] [Full Text] [PDF]
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W. Hallensleben, M. Schwemmle, J. Hausmann, L. Stitz, B. Volk, A. Pagenstecher, and P. Staeheli Borna Disease Virus-Induced Neurological Disorder in Mice: Infection of Neonates Results in Immunopathology J. Virol., May 1, 1998; 72(5): 4379 - 4386. [Abstract] [Full Text] [PDF]
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K. Noske, T. Bilzer, O. Planz, and L. Stitz Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via Induction of Cytotoxic CD8+ T Cells J. Virol., May 1, 1998; 72(5): 4387 - 4395. [Abstract] [Full Text] [PDF]
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