| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 153, Issue 2 517-528, Copyright © 1994 by American Association of Immunologists
ARTICLES |
DJ Erle, MJ Briskin, EC Butcher, A Garcia-Pardo, AI Lazarovits and M Tidswell
Department of Medicine, University of California, San Francisco 94143.
Recirculation of mouse lymphocytes to the gut involves binding of the lymphocyte integrin alpha 4 beta 7 to the mucosal vascular addressin, MAdCAM-1. In humans, indirect evidence suggests that CD4+ T cells that express high levels of alpha 4 beta 7 migrate selectively to the gut. We now report that human adult blood CD8+ T cells and B cells, like CD4+ T cells, have heterogeneous expression of alpha 4 beta 7. In contrast, NK cells, eosinophils, and newborn blood T and B cells have relatively homogeneous expression of alpha 4 beta 7. CD4+ and CD8+ T cell expression of alpha 4 beta 7 was related to age, CD45RA expression, and integrin beta 1 (CD29) expression, suggesting that alpha 4 beta 7 expression changes after primary activation of CD4+ and CD8+ T cells in vivo. To directly determine whether human alpha 4 beta 7 mediates adhesion to MAdCAM-1, we performed in vitro adhesion assays with two alpha 4 beta 7+ human lymphoma cell lines. The results indicate that human alpha 4 beta 7 is a receptor for MAdCAM-1, whereas alpha 4 beta 1 is not. Adhesion of HUT 78 cells to MAdCAM-1 required Mn2+, whereas adhesion of RPMI 8866 cells did not, suggesting that alpha 4 beta 7 may have at least two distinct functional states. The ability of lymphocytes to bind to MAdCAM-1 and recirculate to mucosal organs is likely to be influenced both by the level of alpha 4 beta 7 expression and by the functional state of the alpha 4 beta 7 molecule.
This article has been cited by other articles:
|
|
 |
|
  D. Soler, T. Chapman, L.-L. Yang, T. Wyant, R. Egan, and E. R. Fedyk The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-{alpha}4{beta}7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases J. Pharmacol. Exp. Ther., September 1, 2009; 330(3): 864 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Umansky, O. Abschuetz, W. Osen, M. Ramacher, F. Zhao, M. Kato, and D. Schadendorf Melanoma-Specific Memory T Cells Are Functionally Active in Ret Transgenic Mice without Macroscopic Tumors Cancer Res., November 15, 2008; 68(22): 9451 - 9458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miles, E. Liaskou, B. Eksteen, P. F. Lalor, and D. H. Adams CCL25 and CCL28 promote {alpha}4{beta}7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1257 - G1267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Siddiqui, F. Hollins, S. Saha, and C. E. Brightling Inflammatory cell microlocalisation and airway dysfunction: cause and effect? Eur. Respir. J., December 1, 2007; 30(6): 1043 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Kang and K. A. Kudsk Is There Evidence That the Gut Contributes to Mucosal Immunity in Humans? JPEN J Parenter Enteral Nutr, May 1, 2007; 31(3): 246 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Feagan, G. R. Greenberg, G. Wild, R. N. Fedorak, P. Pare, J. W.D. McDonald, R. Dube, A. Cohen, A. H. Steinhart, S. Landau, et al. Treatment of Ulcerative Colitis with a Humanized Antibody to the {alpha}4{beta}7 Integrin N. Engl. J. Med., June 16, 2005; 352(24): 2499 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rivera-Nieves, T. Olson, G. Bamias, A. Bruce, M. Solga, R. F. Knight, S. Hoang, F. Cominelli, and K. Ley L-Selectin, {alpha}4{beta}1, and {alpha}4{beta}7 Integrins Participate in CD4+ T Cell Recruitment to Chronically Inflamed Small Intestine J. Immunol., February 15, 2005; 174(4): 2343 - 2352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. van Montfrans, R. J. Bennink, K. de Bruin, W. de Jonge, H. J. Verberne, F. J.W. ten Kate, S. J.H. van Deventer, and A. A. te Velde In Vivo Evaluation of 111In-Labeled T-Lymphocyte Homing in Experimental Colitis J. Nucl. Med., October 1, 2004; 45(10): 1759 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Egger, J. Cao, C. McCallum, U. Kidambi, G. Van Riper, E. McCauley, R. A. Mumford, T. J. Lanza, L. S. Lin, S. E. de Laszlo, et al. A Small Molecule {alpha}4{beta}1/{alpha}4{beta}7 Antagonist Differentiates between the Low-Affinity States of {alpha}4{beta}1 and {alpha}4{beta}7: Characterization of Divalent Cation Dependence J. Pharmacol. Exp. Ther., September 1, 2003; 306(3): 903 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Grayson, R. S. Hotchkiss, I. E. Karl, M. J. Holtzman, and D. D. Chaplin Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2213 - H2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wright, A. Hidalgo, J. M. Rodriguez-Frade, S. F. Soriano, M. Mellado, M. Parmo-Cabanas, M. J. Briskin, and J. Teixido The Chemokine Stromal Cell-Derived Factor-1{alpha} Modulates {alpha}4{beta}7 Integrin-Mediated Lymphocyte Adhesion to Mucosal Addressin Cell Adhesion Molecule-1 and Fibronectin J. Immunol., May 15, 2002; 168(10): 5268 - 5277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mishra, S. P. Hogan, E. B. Brandt, N. Wagner, M. W. Crossman, P. S. Foster, and M. E. Rothenberg Enterocyte Expression of the Eotaxin and Interleukin-5 Transgenes Induces Compartmentalized Dysregulation of Eosinophil Trafficking J. Biol. Chem., February 1, 2002; 277(6): 4406 - 4412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oshima, K. P. Pavlick, F. S. Laroux, S. K. Verma, P. Jordan, M. B. Grisham, L. Williams, and J. S. Alexander Regulation and distribution of MAdCAM-1 in endothelial cells in vitro Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1096 - C1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Carlos Leukocyte recruitment at sites of tumor: dissonant orchestration J. Leukoc. Biol., August 1, 2001; 70(2): 171 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Persson, P. Andersson, M. Bodelsson, M. Laurell, J. Malm, and A. Egesten Bactericidal Activity of Human Eosinophilic Granulocytes against Escherichia coli Infect. Immun., June 1, 2001; 69(6): 3591 - 3596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pereira, M. Zhou, A. Mocsai, and C. Lowell Resting Murine Neutrophils Express Functional {{alpha}}4 Integrins that Signal Through Src Family Kinases J. Immunol., March 15, 2001; 166(6): 4115 - 4123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Rott, M. J. Briskin, and E. C. Butcher Expression of {alpha}4{beta}7 and E-selectin ligand by circulating memory B cells: implications for targeted trafficking to mucosal and systemic sites J. Leukoc. Biol., December 1, 2000; 68(6): 807 - 814. [Abstract] [Full Text]
|
|
|
|
|
|
J. Kirveskari, P. Bono, K. Granfors, M. Leirisalo-Repo, S. Jalkanen, and M. Salmi Expression of {alpha}4-integrins on human neutrophils J. Leukoc. Biol., August 1, 2000; 68(2): 243 - 250. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Vajdy, R. S. Veazey, H. K. Knight, A. A. Lackner, and M. R. Neutra Differential Effects of Simian Immunodeficiency Virus Infection on Immune Inductive and Effector Sites in the Rectal Mucosa of Rhesus Macaques Am. J. Pathol., August 1, 2000; 157(2): 485 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ruiz-Velasco, M. Guerrero-Esteo, M. J. Briskin, and J. Teixido The alpha 4 Integrin Subunit Tyr187 Has a Key Role in alpha 4beta 7-Dependent Cell Adhesion J. Biol. Chem., March 15, 2000; 275(10): 7052 - 7059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sriramarao, R. G. DiScipio, R. R. Cobb, M. Cybulsky, G. Stachnick, D. Castaneda, M. Elices, and D. H. Broide VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow Blood, January 15, 2000; 95(2): 592 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Munoz, K. J. Hamann, K. F. Rabe, H. Sano, X. Zhu, and A. R. Leff Augmentation of eosinophil degranulation and LTC4 secretion by integrin-mediated endothelial cell adhesion Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L802 - L810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M SALMI and S JALKANEN Molecules controlling lymphocyte migration to the gut Gut, July 1, 1999; 45(1): 148 - 153. [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Giembycz and M. A. Lindsay Pharmacology of the Eosinophil Pharmacol. Rev., June 1, 1999; 51(2): 213 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kantele, J. Zivny, M. Hakkinen, C. O. Elson, and J. Mestecky Differential Homing Commitments of Antigen-Specific T Cells After Oral or Parenteral Immunization in Humans J. Immunol., May 1, 1999; 162(9): 5173 - 5177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.I. Rojas and A.R. Ahmed Adhesion Receptors in Health and Disease Critical Reviews in Oral Biology & Medicine, January 1, 1999; 10(3): 337 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kantele, M. Hakkinen, Z. Moldoveanu, A. Lu, E. Savilahti, R. D. Alvarez, S. Michalek, and J. Mestecky Differences in Immune Responses Induced by Oral and Rectal Immunizations with Salmonella typhi Ty21a: Evidence for Compartmentalization within the Common Mucosal Immune System in Humans Infect. Immun., December 1, 1998; 66(12): 5630 - 5635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rietzler, M. Bittner, W. Kolanus, A. Schuster, and B. Holzmann The Human WD Repeat Protein WAIT-1 Specifically Interacts with the Cytoplasmic Tails of beta 7-Integrins J. Biol. Chem., October 16, 1998; 273(42): 27459 - 27466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Pachynski, S. W. Wu, M. D. Gunn, and D. J. Erle Secondary Lymphoid-Tissue Chemokine (SLC) Stimulates Integrin {alpha}4{beta}7-Mediated Adhesion of Lymphocytes to Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Under Flow J. Immunol., July 15, 1998; 161(2): 952 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gessl and W. Waldhäusl Increased CD69 and Human Leukocyte Antigen-DR Expression on T Lymphocytes in Insulin-Dependent Diabetes Mellitus of Long Standing J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2204 - 2209. [Abstract] [Full Text]
|
|
|
|
|
|
K. L. Davenpeck, S. A. Sterbinsky, and B. S. Bochner Rat Neutrophils Express alpha 4 and beta 1 Integrins and Bind to Vascular Cell Adhesion Molecule-1 (VCAM-1) and Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Blood, April 1, 1998; 91(7): 2341 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bayless, G. Meininger, J. Scholtz, and G. Davis Osteopontin is a ligand for the alpha4beta1 integrin J. Cell Sci., January 5, 1998; 111(9): 1165 - 1174. [Abstract] [PDF]
|
|
|
|
 |
|
 J. R. Rose, M. B. Williams, L. S. Rott, E. C. Butcher, and H. B. Greenberg Expression of the Mucosal Homing Receptor alpha 4beta 7 Correlates with the Ability of CD8+ Memory T Cells To Clear Rotavirus Infection J. Virol., January 1, 1998; 72(1): 726 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Galperin and M. E. Gershwin Immunopathogenesis of Gastrointestinal and Hepatobiliary Diseases JAMA, December 10, 1997; 278(22): 1946 - 1955. [Abstract] [PDF]
|
|
|
|
|
|
M.-Q. Du, H.-Z. Peng, A. Dogan, T. C. Diss, H. Liu, L.-X. Pan, R. P. Moseley, M. J. Briskin, J. K.C. Chan, and P. G. Isaacson Preferential Dissemination of B-Cell Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma to the Splenic Marginal Zone Blood, November 15, 1997; 90(10): 4071 - 4077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Moyano, B. Carnemolla, C. Dominguez-Jimenez, M. Garcia-Gila, J. P. Albar, P. Sanchez-Aparicio, A. Leprini, G. Querze, L. Zardi, and A. Garcia-Pardo Fibronectin Type III5 Repeat Contains a Novel Cell Adhesion Sequence, KLDAPT, Which Binds Activated alpha 4beta 1 and alpha 4beta 7 Integrins J. Biol. Chem., October 3, 1997; 272(40): 24832 - 24836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fiocchi Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions Am J Physiol Gastrointest Liver Physiol, October 1, 1997; 273(4): G769 - G775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Newham, S. E. Craig, G. N. Seddon, N. R. Schofield, A. Rees, R. M. Edwards, E. Y. Jones, and M. J. Humphries alpha 4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1. INTEGRIN BINDING FOOTPRINTS IDENTIFY ACCESSORY BINDING SITES THAT PLAY A ROLE IN INTEGRIN SPECIFICITY J. Biol. Chem., August 1, 1997; 272(31): 19429 - 19440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Yuan, K. F. Austen, D. S. Friend, M. Heidtman, and J. A. Boyce Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4 (VLA-4)-mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1 (VCAM-1) J. Exp. Med., July 21, 1997; 186(2): 313 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. G. Higgins, M. Cernadas, K. Tan, A. Irie, J.-h. Wang, Y. Takada, and M. B. Brenner The Role of alpha and beta Chains in Ligand Recognition by beta 7 Integrins J. Biol. Chem., August 11, 2000; 275(33): 25652 - 25664. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
