The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maghazachi, A. A.
Right arrow Articles by Schall, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maghazachi, A. A.
Right arrow Articles by Schall, T. J.

The Journal of Immunology, Vol 153, Issue 11 4969-4977, Copyright © 1994 by American Association of Immunologists

ARTICLES

C-C chemokines induce the chemotaxis of NK and IL-2-activated NK cells. Role for G proteins

AA Maghazachi, A al-Aoukaty and TJ Schall
Northeastern Ontario Regional Cancer Centre, Sudbury, Canada.

The C-C chemokines MIP-1 alpha, MCP-1, and RANTES, but not MIP-1 beta, induce the chemotaxis of NK and IL-2-activated NK (IANK) cells, as determined in microchemotaxis assay. Only RANTES and MCP-1, but not MIP- 1 alpha were able to induce the chemokinesis of NK cells. In contrast, none of the C-C chemokines tested was able to induce the chemokinesis of IANK cells. IANK cell chemotaxis in response to MCP-1 or RANTES but not MIP-1 alpha, was inhibited by pertussis toxin (PT). In contrast, cholera toxin (CT) inhibited the ability of all three chemokines to induce the chemotaxis of IANK cells. IANK cells intoxicated with PT lost their ability to migrate in response to RANTES and MCP-1 but not MIP-1 alpha, whereas those intoxicated with CT lost their ability to migrate in response to the three C-C chemokines tested. These results suggest that guanine nucleotide binding (G) proteins are coupled to C-C chemokine receptors in IANK cells. Subsequently, we observed that MIP-1 alpha, MCP-1, and RANTES, but not MIP-1 beta, enhance the binding of guanosine 5'-O-(thiotriphosphate), and increase the hydrolysis of [32P]GTP in IANK cell membranes. Further analysis showed that MIP-1 alpha, RANTES, or MCP-1 did not enhance GTP binding in membranes prepared from IANK cells intoxicated with CT, whereas only RANTES and MCP-1 but not MIP-1 alpha lost their ability to enhance GTP binding to IANK cell membranes prepared from PT-intoxicated cells. The differential inhibitory activity of CT and PT suggests that C-C chemokine receptors are coupled to different G proteins in IANK cells.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
G. R. Campbell and S. A. Spector
CCL2 Increases X4-tropic HIV-1 Entry into Resting CD4+ T Cells
J. Biol. Chem., November 7, 2008; 283(45): 30745 - 30753.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
G. Shi, S. Partida-Sanchez, R. S. Misra, M. Tighe, M. T. Borchers, J. J. Lee, M. I. Simon, and F. E. Lund
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes
J. Exp. Med., October 29, 2007; 204(11): 2705 - 2718.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. Rotondi, L. Chiovato, S. Romagnani, M. Serio, and P. Romagnani
Role of Chemokines in Endocrine Autoimmune Diseases
Endocr. Rev., August 1, 2007; 28(5): 492 - 520.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Chipitsyna, Q. Gong, C. F. Gray, Y. Haroon, E. Kamer, and H. A. Arafat
Induction of Monocyte Chemoattractant Protein-1 Expression by Angiotensin II in the Pancreatic Islets and {beta}-Cells
Endocrinology, May 1, 2007; 148(5): 2198 - 2208.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
W. Li and M. A. Beck
Selenium Deficiency Induced an Altered Immune Response and Increased Survival Following Influenza A/Puerto Rico/8/34 Infection
Experimental Biology and Medicine, March 1, 2007; 232(3): 412 - 419.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Tsuchiyama, Y. Nakamoto, Y. Sakai, Y. Marukawa, M. Kitahara, N. Mukaida, and S. Kaneko
Prolonged, NK Cell-Mediated Antitumor Effects of Suicide Gene Therapy Combined with Monocyte Chemoattractant Protein-1 against Hepatocellular Carcinoma
J. Immunol., January 1, 2007; 178(1): 574 - 583.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
F. J. Culley, A. M. J. Pennycook, J. S. Tregoning, J. S. Dodd, G. Walzl, T. N. Wells, T. Hussell, and P. J. M. Openshaw
Role of CCL5 (RANTES) in Viral Lung Disease.
J. Virol., August 1, 2006; 80(16): 8151 - 8157.
[Abstract] [Full Text] [PDF]

Home page
 Protein Eng Des SelHome page
M. Notohamiprodjo, R. Djafarzadeh, A. Mojaat, I. von Luttichau, H.-J. Grone, and P. J. Nelson
Generation of GPI-linked CCL5 based chemokine receptor antagonists for the suppression of acute vascular damage during allograft transplantation
Protein Eng. Des. Sel., January 1, 2006; 19(1): 27 - 35.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. M. Abrahams, I. Visintin, P. B. Aldo, S. Guller, R. Romero, and G. Mor
A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells
J. Immunol., December 15, 2005; 175(12): 8096 - 8104.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. A. Maghazachi
Insights into Seven and Single Transmembrane-Spanning Domain Receptors and Their Signaling Pathways in Human Natural Killer Cells
Pharmacol. Rev., September 1, 2005; 57(3): 339 - 357.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. N. Forthal, G. Landucci, T. B. Phan, and J. Becerra
Interactions between Natural Killer Cells and Antibody Fc Result in Enhanced Antibody Neutralization of Human Immunodeficiency Virus Type 1
J. Virol., February 15, 2005; 79(4): 2042 - 2049.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A. Antonelli, M. Rotondi, P. Fallahi, P. Romagnani, S. M. Ferrari, A. Paolicchi, E. Ferrannini, and M. Serio
Increase of interferon-{gamma} inducible {alpha} chemokine CXCL10 but not {beta} chemokine CCL2 serum levels in chronic autoimmune thyroiditis
Eur. J. Endocrinol., February 1, 2005; 152(2): 171 - 177.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
B. Schroppel, N. Zhang, P. Chen, D. Chen, J. S. Bromberg, and B. Murphy
Role of Donor-Derived Monocyte Chemoattractant Protein-1 in Murine Islet Transplantation
J. Am. Soc. Nephrol., February 1, 2005; 16(2): 444 - 451.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. V. Yang, C. G. Radu, L. Wang, M. Riedinger, and O. N. Witte
Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A
Blood, February 1, 2005; 105(3): 1127 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. A. Maghazachi
G protein-coupled receptors in natural killer cells
J. Leukoc. Biol., July 1, 2003; 74(1): 16 - 24.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
B. Kutlu, M. I. Darville, A. K. Cardozo, and D. L. Eizirik
Molecular Regulation of Monocyte Chemoattractant Protein-1 Expression in Pancreatic {beta}-Cells
Diabetes, February 1, 2003; 52(2): 348 - 355.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. L. Hodge, W. B. Schill, J. M. Wang, I. Blanca, D. A. Reynolds, J. R. Ortaldo, and H. A. Young
IL-2 and IL-12 Alter NK Cell Responsiveness to IFN-{gamma}-Inducible Protein 10 by Down-Regulating CXCR3 Expression
J. Immunol., June 15, 2002; 168(12): 6090 - 6098.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. J. Robertson
Role of chemokines in the biology of natural killer cells
J. Leukoc. Biol., February 1, 2002; 71(2): 173 - 183.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Piemonti, B. E. Leone, R. Nano, A. Saccani, P. Monti, P. Maffi, G. Bianchi, A. Sica, G. Peri, R. Melzi, et al.
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation
Diabetes, January 1, 2002; 51(1): 55 - 65.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kawakami, Y. Kinjo, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Nakayama, M. Taniguchi, and A. Saito
Monocyte Chemoattractant Protein-1-Dependent Increase of V{alpha}14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection
J. Immunol., December 1, 2001; 167(11): 6525 - 6532.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. P. Perera, C. K. Goldman, and T. A. Waldmann
Comparative assessment of virulence of recombinant vaccinia viruses expressing IL-2 and IL-15 in immunodeficient mice
PNAS, April 5, 2001; (2001) 81080298.
[Abstract] [Full Text]

Home page
 JEMHome page
D. Huang, J. Wang, P. Kivisakk, B. J. Rollins, and R. M. Ransohoff
Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis
J. Exp. Med., March 19, 2001; 193(6): 713 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. M. Schmidt and D. M. Stern
Chemokines on the Rise : MCP-1 and Restenosis
Arterioscler. Thromb. Vasc. Biol., March 1, 2001; 21(3): 297 - 299.
[Full Text] [PDF]

Home page
 BloodHome page
M. Inngjerdingen, B. Damaj, and A. A. Maghazachi
Expression and regulation of chemokine receptors in human natural killer cells
Blood, January 15, 2001; 97(2): 367 - 375.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. A. Fehniger and M. A. Caligiuri
Interleukin 15: biology and relevance to human disease
Blood, January 1, 2001; 97(1): 14 - 32.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Nokihara, H. Yanagawa, Y. Nishioka, S. Yano, N. Mukaida, K. Matsushima, and S. Sone
Natural Killer Cell-dependent Suppression of Systemic Spread of Human Lung Adenocarcinoma Cells by Monocyte Chemoattractant Protein-1 Gene Transfection in Severe Combined Immunodeficient Mice
Cancer Res., December 1, 2000; 60(24): 7002 - 7007.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
X. Shang, B. Qiu, K. A. Frait, J. S. Hu, J. Sonstein, J. L. Curtis, B. Lu, C. Gerard, and S. W. Chensue
Chemokine Receptor 1 Knockout Abrogates Natural Killer Cell Recruitment and Impairs Type-1 Cytokines in Lymphoid Tissue during Pulmonary Granuloma Formation
Am. J. Pathol., December 1, 2000; 157(6): 2055 - 2063.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. D. M. Soede, Y. M. Wijnands, M. Kamp, M. A. van der Valk, and E. Roos
Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi
Blood, July 15, 2000; 96(2): 691 - 698.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Inngjerdingen, B. Damaj, and A. A. Maghazachi
Human NK Cells Express CC Chemokine Receptors 4 and 8 and Respond to Thymus and Activation-Regulated Chemokine, Macrophage-Derived Chemokine, and I-309
J. Immunol., April 15, 2000; 164(8): 4048 - 4054.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Nieto, J. L. Rodriguez-Fernandez, F. Navarro, D. Sancho, J. M.R. Frade, M. Mellado, C. Martinez-A, C. Cabanas, and F. Sanchez-Madrid
Signaling Through CD43 Induces Natural Killer Cell Activation, Chemokine Release, and PYK-2 Activation
Blood, October 15, 1999; 94(8): 2767 - 2777.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. C. S. Aliberti, F. S. Machado, J. T. Souto, A. P. Campanelli, M. M. Teixeira, R. T. Gazzinelli, and J. S. Silva
beta -Chemokines Enhance Parasite Uptake and Promote Nitric Oxide-Dependent Microbiostatic Activity in Murine Inflammatory Macrophages Infected with Trypanosoma cruzi
Infect. Immun., September 1, 1999; 67(9): 4819 - 4826.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K F Chung and P J Barnes
Cytokines in asthma
Thorax, September 1, 1999; 54(9): 825 - 857.
[Full Text]

Home page
 CirculationHome page
M. Noris, E. Daina, S. Gamba, S. Bonazzola, and G. Remuzzi
Interleukin-6 and RANTES in Takayasu Arteritis : A Guide for Therapeutic Decisions?
Circulation, July 6, 1999; 100(1): 55 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Vester, K. Muller, W. Solbach, and T. Laskay
Early Gene Expression of NK Cell-Activating Chemokines in Mice Resistant to Leishmania major
Infect. Immun., June 1, 1999; 67(6): 3155 - 3159.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. L. Rabin, M. K. Park, F. Liao, R. Swofford, D. Stephany, and J. M. Farber
Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling
J. Immunol., April 1, 1999; 162(7): 3840 - 3850.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Jinquan, S. Quan, G. Feili, C. G. Larsen, and K. Thestrup-Pedersen
Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4
J. Immunol., April 1, 1999; 162(7): 4285 - 4292.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Al-Aoukaty, B. Rolstad, and A. A. Maghazachi
Recruitment of Pleckstrin and Phosphoinositide 3-Kinase {gamma} into the Cell Membranes, and Their Association with G{beta}{gamma} After Activation of NK Cells with Chemokines
J. Immunol., March 15, 1999; 162(6): 3249 - 3255.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. J. Hirsch and T. Shenk
Human Cytomegalovirus Inhibits Transcription of the CC Chemokine MCP-1 Gene
J. Virol., January 1, 1999; 73(1): 404 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Barnes, K. F. Chung, and C. P. Page
Inflammatory Mediators of Asthma: An Update
Pharmacol. Rev., December 1, 1998; 50(4): 515 - 596.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Nieto, F. Navarro, J. J. Perez-Villar, M. A. del Pozo, R. Gonzalez-Amaro, M. Mellado, J. M. R. Frade, C. Martinez-A, M. Lopez-Botet, and F. Sanchez-Madrid
Roles of Chemokines and Receptor Polarization in NK-Target Cell Interactions
J. Immunol., October 1, 1998; 161(7): 3330 - 3339.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. P. Salazar-Mather, J. S. Orange, and C. A. Biron
Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1alpha (MIP-1alpha )-dependent Pathways
J. Exp. Med., January 5, 1998; 187(1): 1 - 14.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. Godiska, D. Chantry, C. J. Raport, S. Sozzani, P. Allavena, D. Leviten, A. Mantovani, and P. W. Gray
Human Macrophage-derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells
J. Exp. Med., May 5, 1997; 185(9): 1595 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. P. Perera, C. K. Goldman, and T. A. Waldmann
Comparative assessment of virulence of recombinant vaccinia viruses expressing IL-2 and IL-15 in immunodeficient mice
PNAS, April 24, 2001; 98(9): 5146 - 5151.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.