| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 153, Issue 11 4940-4947, Copyright © 1994 by American Association of Immunologists
ARTICLES |
K Hellstrand, A Asea, C Dahlgren and S Hermodsson
Department of Virology, University of Goteborg, Sweden.
Monocytes, recovered by centrifugal elutriation, effectively inhibit functions of human NK cells in vitro. Histamine, acting via monocyte H2- type histamine receptors, abrogates the inhibitory signal. The aim of this study was to define the histamine-reversible mechanism by which monocytes inhibit NK cells with special reference to the respiratory burst activity of monocytes. Monocytes recovered from patients with chronic granulomatous disease did not suppress NK cell function, indicating the requirement of intact nicotinamide-adenine dinucleotide phosphate (NAPDH) oxidase activity of monocytes to inhibit NK cells. Furthermore, catalase, a scavenger of hydrogen peroxide (H2O2), was found to potently reverse the monocyte-induced inhibition of NK cell function; on the other hand, superoxide dismutase (a scavenger of superoxide anion), hydroxyl radical scavengers such as mannitol and deferoxamine, the hypochlorous acid scavenger taurin, or the nitric oxide synthetase inhibitor NG-monomethyl-L-arginine (L-NMMA) did not affect the monocyte-derived, suppressive signal. H2O2, at micromolar concentrations, reconstituted the inhibitory effects of monocytes on NK cell function. Histamine had no scavenger activity but effectively suppressed the generation of H2O2 in isolated monocytes. This effect of histamine was transduced by H2-type histamine receptors. We conclude that the histamine-reversible, inhibitory effect of elutriated monocytes on NK cells is dependent on the formation of reactive oxygen metabolites by monocytes and that H2O2 is a pivotal mediator of the suppressive signal.
This article has been cited by other articles:
|
|
 |
|
  T. Ando, K. Mimura, C. C. Johansson, M. G. Hanson, D. Mougiakakos, C. Larsson, T. Martins da Palma, D. Sakurai, H. Norell, M. Li, et al. Transduction with the Antioxidant Enzyme Catalase Protects Human T Cells against Oxidative Stress J. Immunol., December 15, 2008; 181(12): 8382 - 8390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Martner, C. Dahlgren, J. C. Paton, and A. E. Wold Pneumolysin Released during Streptococcus pneumoniae Autolysis Is a Potent Activator of Intracellular Oxygen Radical Production in Neutrophils Infect. Immun., September 1, 2008; 76(9): 4079 - 4087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Damaj, C. B. Becerra, H. J. Esber, Y. Wen, and A. A. Maghazachi Functional Expression of H4 Histamine Receptor in Human Natural Killer Cells, Monocytes, and Dendritic Cells J. Immunol., December 1, 2007; 179(11): 7907 - 7915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Brune, S. Castaigne, J. Catalano, K. Gehlsen, A. D. Ho, W.-K. Hofmann, D. E. Hogge, B. Nilsson, R. Or, A. I. Romero, et al. Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial Blood, July 1, 2006; 108(1): 88 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. B. Thoren, A. I. Romero, and K. Hellstrand Oxygen Radicals Induce Poly(ADP-Ribose) Polymerase-Dependent Cell Death in Cytotoxic Lymphocytes. J. Immunol., June 15, 2006; 176(12): 7301 - 7307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Thoren, A. Romero, M. Lindh, C. Dahlgren, and K. Hellstrand A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals J. Leukoc. Biol., December 1, 2004; 76(6): 1180 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hansson, A. Romero, F. Thoren, S. Hermodsson, and K. Hellstrand Activation of cytotoxic lymphocytes by interferon-{alpha}: role of oxygen radical-producing mononuclear phagocytes J. Leukoc. Biol., December 1, 2004; 76(6): 1207 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Betten, C. Dahlgren, U.-H. Mellqvist, S. Hermodsson, and K. Hellstrand Oxygen radical-induced natural killer cell dysfunction: role of myeloperoxidase and regulation by serotonin J. Leukoc. Biol., June 1, 2004; 75(6): 1111 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Armstrong and J. W. Spears Effect of boron supplementation of pig diets on the production of tumor necrosis factor-{alpha} and interferon-{gamma} J Anim Sci, October 1, 2003; 81(10): 2552 - 2561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Hamill Research Briefings Integr Cancer Ther, March 1, 2003; 2(1): 91 - 93. [PDF]
|
|
|
|
 |
|
 T. Morichika, H. K. Takahashi, H. Iwagaki, T. Yoshino, R. Tamura, M. Yokoyama, S. Mori, T. Akagi, M. Nishibori, and N. Tanaka Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-{alpha} Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 624 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. D. Davis, M. Jefford, P. Parente, and J. Cebon Rational approaches to human cancer immunotherapy J. Leukoc. Biol., January 1, 2003; 73(1): 3 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schmidt, S. Larsen, L. Bastholt, K. Fode, C. Rytter, and H. von der Maase A phase II study of outpatient subcutaneous histamine dihydrochloride, interleukin-2 and interferon-{alpha} in patients with metastatic melanoma Ann. Onc., December 1, 2002; 13(12): 1919 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Donskov, H. von der Maase, R. Henriksson, U. Stierner, P. Wersall, H. Nellemann, K. Hellstrand, K. Engman, and P. Naredi Outpatient treatment with subcutaneous histamine dihydrochloride in combination with interleukin-2 and interferon-{alpha} in patients with metastatic renal cell carcinoma: results of an open single-armed multicentre phase II study Ann. Onc., March 1, 2002; 13(3): 441 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Agarwala, J. Glaspy, S. J. O'Day, M. Mitchell, J. Gutheil, E. Whitman, R. Gonzalez, E. Hersh, L. Feun, R. Belt, et al. Results From a Randomized Phase III Study Comparing Combined Treatment With Histamine Dihydrochloride Plus Interleukin-2 Versus Interleukin-2 Alone in Patients With Metastatic Melanoma J. Clin. Oncol., January 1, 2002; 20(1): 125 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Takahashi, A. Yoshida, H. Iwagaki, T. Yoshino, H. Itoh, T. Morichika, M. Yokoyama, T. Akagi, N. Tanaka, S. Mori, et al. Histamine Regulation of Interleukin-18-Initiating Cytokine Cascade Is Associated with Down-Regulation of Intercellular Adhesion Molecule-1 Expression in Human Peripheral Blood Mononuclear Cells J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 227 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Betten, C. Dahlgren, S. Hermodsson, and K. Hellstrand Serotonin protects NK cells against oxidatively induced functional inhibition and apoptosis J. Leukoc. Biol., July 1, 2001; 70(1): 65 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U.-H. Mellqvist, M. Hansson, M. Brune, C. Dahlgren, S. Hermodsson, and K. Hellstrand Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine Blood, September 1, 2000; 96(5): 1961 - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kohka, M. Nishibori, H. Iwagaki, N. Nakaya, T. Yoshino, K. Kobashi, K. Saeki, N. Tanaka, and T. Akagi Histamine Is a Potent Inducer of IL-18 and IFN-{gamma} in Human Peripheral Blood Mononuclear Cells J. Immunol., June 15, 2000; 164(12): 6640 - 6646. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
