The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, K.
Right arrow Articles by Phan, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, K.
Right arrow Articles by Phan, S. H.

The Journal of Immunology, Vol 153, Issue 10 4733-4741, Copyright © 1994 by American Association of Immunologists

ARTICLES

Lung monocyte chemoattractant protein-1 gene expression in bleomycin- induced pulmonary fibrosis

K Zhang, M Gharaee-Kermani, ML Jones, JS Warren and SH Phan
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.

Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) may play an important role in pulmonary inflammation. In vitro studies show that a number of cell types are capable of producing MCP-1. In this study, MCP-1 expression in lungs of rats with bleomycin (BLM)- induced pulmonary fibrosis is examined to evaluate its cellular origin and potential role in pathogenesis. Lung fibrosis was induced in male Fisher 344 rats by endotracheal injection on day 0. On selected days after injection, lungs were harvested for in situ and Northern hybridization analyses for MCP-1 mRNA expression, immunochemical and histochemical analyses for MCP-1 protein expression, and identification of cell type. Northern analysis revealed significant elevation in lung MCP-1 mRNA expression beginning on day 3 post-BLM treatment, increasing to a peak on day 7, and then decreasing toward control levels after day 21. In situ hybridization combined with histochemical staining with chromotrope 2R indicate that most of the cells expressing MCP-1 mRNA at these time points are primarily eosinophils. A few scattered reactive fibroblasts, some mononuclear cells, epithelial cells, and cells of certain blood vessel walls also express this mRNA. Increased MCP-1 protein expression also was found to be predominantly within and adjacent to eosinophils. The eosinophils expressing this mRNA were found predominantly within areas of active fibrosis. The kinetics of increase in the number of cells expressing significant MCP-1 mRNA in lung sections paralleled that for MCP-1 mRNA expression, as assessed by Northern analysis. These results, for the first time, demonstrate that MCP-1 is up-regulated significantly in this rat animal model, and that infiltrating eosinophils represent the major cellular source for this increased MCP-1 expression.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
M. Furonaka, N. Hattori, T. Tanimoto, T. Senoo, N. Ishikawa, K. Fujitaka, Y. Haruta, A. Yokoyama, and N. Kohno
Suplatast Tosilate Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice
J. Pharmacol. Exp. Ther., January 1, 2009; 328(1): 55 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
J. H. W. Distler, A. Akhmetshina, G. Schett, and O. Distler
Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis
Rheumatology, November 4, 2008; (2008) ken401v1.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Saito, S. Tasaka, K.-i. Inoue, K. Miyamoto, Y. Nakano, Y. Ogawa, W. Yamada, Y. Shiraishi, N. Hasegawa, S. Fujishima, et al.
Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice
Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 566 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. A. Brant and J. P. Fabisiak
Nickel Alterations of TLR2-Dependent Chemokine Profiles in Lung Fibroblasts Are Mediated by COX-2
Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 591 - 599.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. B. Moore and C. M. Hogaboam
Murine models of pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L152 - L160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Z. Yin, Y. Tong, H. Zhu, and M. A. Watsky
ClC-3 is required for LPA-activated Cl- current activity and fibroblast-to-myofibroblast differentiation
Am J Physiol Cell Physiol, February 1, 2008; 294(2): C535 - C542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Hinz, S. H. Phan, V. J. Thannickal, A. Galli, M.-L. Bochaton-Piallat, and G. Gabbiani
The Myofibroblast: One Function, Multiple Origins
Am. J. Pathol., June 1, 2007; 170(6): 1807 - 1816.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. K. Dhillon, D. Pinson, S. Dhillon, O. Tawfik, M. Danley, M. Davis, O. Nemon, M. Mayo, A. Kumar, Y.-J. Tsai, et al.
Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1233 - L1240.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. M. Pierce, K. Carpenter, C. Jakubzick, S. L. Kunkel, K. R. Flaherty, F. J. Martinez, and C. M. Hogaboam
Therapeutic Targeting of CC Ligand 21 or CC Chemokine Receptor 7 Abrogates Pulmonary Fibrosis Induced by the Adoptive Transfer of Human Pulmonary Fibroblasts to Immunodeficient Mice
Am. J. Pathol., April 1, 2007; 170(4): 1152 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
Y Motomura, W I Khan, R T El-Sharkawy, M Verma-Gandhu, E F Verdu, J Gauldie, and S M Collins
Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
Gut, May 1, 2006; 55(5): 662 - 670.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. Agostini and C. Gurrieri
Chemokine/Cytokine cocktail in idiopathic pulmonary fibrosis.
Proceedings of the ATS, January 1, 2006; 3(4): 357 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. N. Lama and S. H. Phan
The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond.
Proceedings of the ATS, January 1, 2006; 3(4): 373 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Huaux, M. Gharaee-Kermani, T. Liu, V. Morel, B. McGarry, M. Ullenbruch, S. L. Kunkel, J. Wang, Z. Xing, and S. H. Phan
Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis
Am. J. Pathol., December 1, 2005; 167(6): 1485 - 1496.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Gharaee-Kermani, K. Hatano, Y. Nozaki, and S. H. Phan
Gender-Based Differences in Bleomycin-Induced Pulmonary Fibrosis
Am. J. Pathol., June 1, 2005; 166(6): 1593 - 1606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Z. Yin and M. A. Watsky
Chloride channel activity in human lung fibroblasts and myofibroblasts
Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1110 - L1116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. B. Moore, J. E. Kolodsick, V. J. Thannickal, K. Cooke, T. A. Moore, C. Hogaboam, C. A. Wilke, and G. B. Toews
CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury
Am. J. Pathol., March 1, 2005; 166(3): 675 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Murakami, N. Nagaya, T. Itoh, T. Fujii, T. Iwase, K. Hamada, H. Kimura, and K. Kangawa
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1172 - L1177.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Belperio, M. Dy, L. Murray, M. D. Burdick, Y. Y. Xue, R. M. Strieter, and M. P. Keane
The Role of the Th2 CC Chemokine Ligand CCL17 in Pulmonary Fibrosis
J. Immunol., October 1, 2004; 173(7): 4692 - 4698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. Inoshima, K. Kuwano, N. Hamada, N. Hagimoto, M. Yoshimi, T. Maeyama, A. Takeshita, S. Kitamoto, K. Egashira, and N. Hara
Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L1038 - L1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Huaux, T. Liu, B. McGarry, M. Ullenbruch, Z. Xing, and S. H. Phan
Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis
J. Immunol., November 15, 2003; 171(10): 5470 - 5481.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. E. Kolodsick, M. Peters-Golden, J. Larios, G. B. Toews, V. J. Thannickal, and B. B. Moore
Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation
Am. J. Respir. Cell Mol. Biol., November 1, 2003; 29(5): 537 - 544.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al.
Idiopathic Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): S1 - 105.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. Strieter
To Clot or Not to Clot, That Is the Question in Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1589 - 1590.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. A. Belperio, M. Dy, M. D. Burdick, Y. Y. Xue, K. Li, J. A. Elias, and M. P. Keane
Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 419 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. B. Moore, R. Paine III, P. J. Christensen, T. A. Moore, S. Sitterding, R. Ngan, C. A. Wilke, W. A. Kuziel, and G. B. Toews
Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling
J. Immunol., October 15, 2001; 167(8): 4368 - 4377.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Okazaki, A. Nakao, H. Nakano, F. Takahashi, K. Takahashi, O. Shimozato, K. Takeda, H. Yagita, and K. Okumura
Impairment of Bleomycin-Induced Lung Fibrosis in CD28-Deficient Mice
J. Immunol., August 15, 2001; 167(4): 1977 - 1981.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. P. Keane, J. A. Belperio, M. D. Burdick, and R. M. Strieter
IL-12 attenuates bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L92 - L97.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. M. Strieter
Mechanisms of Pulmonary Fibrosis : Conference Summary
Chest, July 1, 2001; 120(2007): 77S - 85S.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Blease, B. Mehrad, N. W. Lukacs, S. L. Kunkel, T. J. Standiford, and C. M. Hogaboam
Antifungal and Airway Remodeling Roles for Murine Monocyte Chemoattractant Protein-1/CCL2 During Pulmonary Exposure to Asperigillus fumigatus Conidia
J. Immunol., February 1, 2001; 166(3): 1832 - 1842.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
O. GIRAUD, P.-F. SEINCE, C. ROLLAND, V. LEÇON-MALAS, J.-M. DESMONTS, M. AUBIER, and M. DEHOUX
Halothane Reduces the Early Lipopolysaccharide-induced Lung Inflammation in Mechanically Ventilated Rats
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2278 - 2286.
[Abstract] [Full Text]

Home page
 J. Leukoc. Biol.Home page
H. Hao, D. A. Cohen, C. D. Jennings, J. S. Bryson, and A. M. Kaplan
Bleomycin-induced pulmonary fibrosis is independent of eosinophils
J. Leukoc. Biol., October 1, 2000; 68(4): 515 - 521.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
T. Yamamoto, B. Eckes, C. Mauch, K. Hartmann, and T. Krieg
Monocyte Chemoattractant Protein-1 Enhances Gene Expression and Synthesis of Matrix Metalloproteinase-1 in Human Fibroblasts by an Autocrine IL-1{alpha} Loop
J. Immunol., June 15, 2000; 164(12): 6174 - 6179.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Tokuda, M. Itakura, N. Onai, H. Kimura, T. Kuriyama, and K. Matsushima
Pivotal Role of CCR1-Positive Leukocytes in Bleomycin- Induced Lung Fibrosis in Mice
J. Immunol., March 1, 2000; 164(5): 2745 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H.-Y. Zhang and S. H. Phan
Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor beta 1
Am. J. Respir. Cell Mol. Biol., December 1, 1999; 21(6): 658 - 665.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
C. M. Hogaboam, C. L. Bone-Larson, S. Lipinski, N. W. Lukacs, S. W. Chensue, R. M. Strieter, and S. L. Kunkel
Differential Monocyte Chemoattractant Protein-1 and Chemokine Receptor 2 Expression by Murine Lung Fibroblasts Derived from Th1- and Th2-Type Pulmonary Granuloma Models
J. Immunol., August 15, 1999; 163(4): 2193 - 2201.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. M. Hogaboam, C. S. Gallinat, C. Bone-Larson, S. W. Chensue, N. W. Lukacs, R. M. Strieter, and S. L. Kunkel
Collagen Deposition in a Non-Fibrotic Lung Granuloma Model after Nitric Oxide Inhibition
Am. J. Pathol., December 1, 1998; 153(6): 1861 - 1872.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Hogaboam, N. W. Lukacs, S. W. Chensue, R. M. Strieter, and S. L. Kunkel
Monocyte Chemoattractant Protein-1 Synthesis by Murine Lung Fibroblasts Modulates CD4+ T Cell Activation
J. Immunol., May 1, 1998; 160(9): 4606 - 4614.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. M. McKee, C. J. Lowenstein, M. R. Horton, J. Wu, C. Bao, B. Y. Chin, A. M.K. Choi, and P. W. Noble
Hyaluronan Fragments Induce Nitric-oxide Synthase in Murine Macrophages through a Nuclear Factor kappa B-dependent Mechanism
J. Biol. Chem., March 21, 1997; 272(12): 8013 - 8018.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Gharaee-Kermani, E. M. Denholm, and S. H. Phan
Costimulation of Fibroblast Collagen and Transforming Growth Factor beta 1 Gene Expression by Monocyte Chemoattractant Protein-1 via Specific Receptors
J. Biol. Chem., July 26, 1996; 271(30): 17779 - 17784.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.