| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 153, Issue 10 4427-4435, Copyright © 1994 by American Association of Immunologists
ARTICLES |
PP Jokhi, A King, AM Sharkey, SK Smith and YW Loke
Department of Pathology, University of Cambridge, United Kingdom.
At the time of human embryo implantation, large numbers of maternal CD56brightCD16- NK cells appear in the uterus. These unusual lymphocytes are believed to control the migration and differentiation of highly invasive fetally derived trophoblast cells, which infiltrate into the maternal uterus to remodel the spiral arteries during the first trimester. One possible mechanism of control is by cytokine production. In this study, highly purified (> 99%) populations of first trimester decidual CD56brightCD16- NK cells and CD3+ T lymphocytes were obtained by using a FACS. These cells were examined by reverse transcriptase PCR for their expression of mRNAs for the following cytokines: granulocyte-macrophage (GM)-CSF, CSF-1, TNF-alpha, IFN- gamma, TGF-beta 1, leukemia-inhibitory factor (LIF), and IL-2. Then, the expression was compared with that of resting PBL. The identity of the PCR products was verified by Southern blotting and hybridization with cytokine-specific probes. Both decidual CD56brightCD16- NK cells and CD3+ T cells were found to express mRNA for CSF-1, TNF-alpha, IFN- gamma TGF-beta 1, and LIF, but GM-CSF mRNA was detected only in CD56bright NK cells. IL-2 mRNA was detected in only some decidual T cell samples, and then only after at least two rounds of amplification. In contrast, peripheral blood CD56brightCD16- NK cells, CD56dimCD16+ NK cells, and CD3+ T cells expressed mRNA only for TNF-alpha and TGF-beta 1, but not for GM-CSF, CSF-1, IFN-gamma, LIF, or IL-2. These results suggest that both decidual NK cells and decidual T cells produce a variety of cytokines that may be involved in the control of trophoblast migration and differentiation during pregnancy.
This article has been cited by other articles:
|
|
 |
|
  W.-H. Zhou, L. Dong, M.-R. Du, X.-Y. Zhu, and D.-J. Li Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4 Reproduction, March 1, 2008; 135(3): 385 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Blanco, I. Tirado, R. Munoz-Fernandez, A. C. Abadia-Molina, J. M. Garcia-Pacheco, J. Pena, and E. G. Olivares Human decidual stromal cells express HLA-G Effects of cytokines and decidualization Hum. Reprod., January 1, 2008; 23(1): 144 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fluhr, S. Krenzer, G. M. Stein, B. Stork, M. Deperschmidt, D. Wallwiener, S. Wesselborg, M. Zygmunt, and P. Licht Interferon-{gamma} and tumor necrosis factor-{alpha} sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis J. Cell Sci., December 1, 2007; 120(23): 4126 - 4133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Evans, L. Nguyen, J. Chan, B. A. Innes, J. N. Bulmer, M. D. Kilby, and M. Hewison Effects of 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells Biol Reprod, December 1, 2006; 75(6): 816 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Miwa, S. Hayakawa, S. Miyazaki, S. Myojo, Y. Sasaki, M. Sakai, O. Takikawa, and S. Saito IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-{gamma} increase in normal pregnancy but decrease in spontaneous abortion Mol. Hum. Reprod., December 1, 2005; 11(12): 865 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kitaya, T. Yamaguchi, and H. Honjo Central Role of Interleukin-15 in Postovulatory Recruitment of Peripheral Blood CD16(-) Natural Killer Cells into Human Endometrium J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2932 - 2940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dosiou and L. C. Giudice Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives Endocr. Rev., February 1, 2005; 26(1): 44 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-F. Chen, K.-H. Chao, J.-Y. Shew, Y.-S. Yang, and H.-N. Ho Expression of leukemia inhibitory factor and its receptor is not altered in the decidua and chorionic villi of human anembryonic pregnancy Hum. Reprod., July 1, 2004; 19(7): 1647 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kitaya, T. Nakayama, N. Daikoku, S. Fushiki, and H. Honjo Spatial and Temporal Expression of Ligands for CXCR3 and CXCR4 in Human Endometrium J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2470 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kudo, T. Hara, T. Katsuki, A. Toyofuku, Y. Katsura, O. Takikawa, T. Fujii, and K. Ohama Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium Hum. Reprod., May 1, 2004; 19(5): 1222 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. van der Meer, H.G.M. Lukassen, M.J.C. van Lierop, F. Wijnands, S. Mosselman, D.D.M. Braat, and I. Joosten Membrane-bound HLA-G activates proliferation and interferon-{gamma} production by uterine natural killer cells Mol. Hum. Reprod., March 1, 2004; 10(3): 189 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Chao, M.-Y. Wu, J.-H. Yang, S.-U. Chen, Y.-S. Yang, and H.-N. Ho Expression of the interleukin-2 receptor {alpha} (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies Mol. Hum. Reprod., July 1, 2002; 8(7): 667 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Okada, T. Nakajima, M. Sanezumi, A. Ikuta, K. Yasuda, and H. Kanzaki Progesterone Enhances Interleukin-15 Production in Human Endometrial Stromal Cells in Vitro J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4765 - 4770. [Abstract] [Full Text]
|
|
|
|
|
|
K. Kitaya, J. Yasuda, I. Yagi, Y. Tada, S. Fushiki, and H. Honjo IL-15 Expression at Human Endometrium and Decidua Biol Reprod, September 1, 2000; 63(3): 683 - 687. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. A. Ashkar, J. P. Di Santo, and B. A. Croy Interferon {gamma} Contributes to Initiation of Uterine Vascular Modification, Decidual Integrity, and Uterine Natural Killer Cell Maturation during Normal Murine Pregnancy J. Exp. Med., July 17, 2000; 192(2): 259 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Auernhammer and S. Melmed Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function Endocr. Rev., June 1, 2000; 21(3): 313 - 345. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Kudo, C.A.R. Boyd, I.L. Sargent, and C.W.G. Redman Modulation of indoleamine 2,3-dioxygenase by interferon-{gamma} in human placental chorionic villi Mol. Hum. Reprod., April 1, 2000; 6(4): 369 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Verma, S. E. Hiby, Y. W. Loke, and A. King Human Decidual Natural Killer Cells Express the Receptor for and Respond to the Cytokine Interleukin 15 Biol Reprod, April 1, 2000; 62(4): 959 - 968. [Abstract] [Full Text]
|
|
|
|
|
|
K. Clifford, A.M. Flanagan, and L. Regan Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study Hum. Reprod., November 1, 1999; 14(11): 2727 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Searle, R. K. Jones, and J. N. Bulmer Phenotypic Analysis and Proliferative Responses of Human Endometrial Granulated Lymphocytes during the Menstrual Cycle Biol Reprod, April 1, 1999; 60(4): 871 - 878. [Abstract] [Full Text]
|
|
|
|
|
|
A. Meisser, D. Chardonnens, A. Campana, and P. Bischof Effects of tumour necrosis factor-{alpha}, interleukin-1 {alpha}, macrophage colony stimulating factor and transforming growth factor ß on trophoblastic matrix metalloproteinases Mol. Hum. Reprod., March 1, 1999; 5(3): 252 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. King, L. Gardner, and Y.W. Loke Co-stimulation of human decidual natural killer cells by interleukin-2 and stromal cells Hum. Reprod., March 1, 1999; 14(3): 656 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.M. Sharkey, A. King, D.E. Clark, T.D. Burrows, P.P. Jokhi, D.S. Charnock-Jones, Y.W. Loke, and S.K. Smith Localization of Leukemia Inhibitory Factor and Its Receptor in Human Placenta Throughout Pregnancy Biol Reprod, February 1, 1999; 60(2): 355 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Allen and M. Nilsen-Hamilton Granzymes D, E, F, and G Are Regulated Through Pregnancy and by IL-2 and IL-15 in Granulated Metrial Gland Cells J. Immunol., September 15, 1998; 161(6): 2772 - 2779. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
