The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fidock, D. A.
Right arrow Articles by Meis, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fidock, D. A.
Right arrow Articles by Meis, J. F.

The Journal of Immunology, Vol 153, Issue 1 190-204, Copyright © 1994 by American Association of Immunologists

ARTICLES

Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants [published erratum appears in J Immunol 1994 Dec 1;153(11):5347]

DA Fidock, H Gras-Masse, JP Lepers, K Brahimi, L Benmohamed, S Mellouk, C Guerin-Marchand, A Londono, L Raharimalala and JF Meis
Bio-Medical Parasitology Laboratory, Pasteur Institute, Paris, France.

We have previously identified a Plasmodium falciparum liver stage- specific Ag (LSA-1) found to encode tandem 17 amino acid repeats harboring B cell determinants. Here we extend this study in terms of sequence analysis, protein localization, and immunologic properties. Analysis of the N- and C-terminal regions of LSA-1 from the T9/96 clone reveals high sequence conservation with LSA-1 from NF54. This 200-kDa protein is detected throughout liver schizogony and accumulates in the parasitophorous vacuole space. In our investigation of T and B cell responses to LSA-1, we have focused on both the area of the C-terminal, nonrepetitive "hinge" region and the conserved repetitive region and derived synthetic peptides. These were found to contain major B and T cell determinants. High prevalences and elevated Ab levels to LSA-1, directed primarily, although not exclusively, to the repetitive region, were detected in sera of individuals from one moderately high and two low transmission malaria-endemic areas (prevalences of 97%, 75, and 77%, respectively). In one of these low transmission areas, secretion of the cytokine IFN-gamma, known to inhibit malaria liver stages, and T cell proliferation were detected in PBMC of 22 to 48% and 6 to 20%, respectively, of individuals in response to separate LSA-1 peptides. These results complement the recent finding of conserved CTL epitopes in LSA-1 and support the assertion that immune responses to LS Ag are involved in protection against malaria pre-erythrocytic stages.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
G. S. Noland, B. Hendel-Paterson, X. M. Min, A. M. Moormann, J. M. Vulule, D. L. Narum, D. E. Lanar, J. W. Kazura, and C. C. John
Low Prevalence of Antibodies to Preerythrocytic but Not Blood-Stage Plasmodium falciparum Antigens in an Area of Unstable Malaria Transmission Compared to Prevalence in an Area of Stable Malaria Transmission
Infect. Immun., December 1, 2008; 76(12): 5721 - 5728.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
X. Zhang, F. A. Castelli, X. Zhu, M. Wu, B. Maillere, and L. BenMohamed
Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D
Clin. Vaccine Immunol., September 1, 2008; 15(9): 1436 - 1449.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Rodriguez, J. Goudsmit, A. Companjen, R. Mintardjo, G. Gillissen, D. Tax, J. Sijtsma, G. J. Weverling, L. Holterman, D. E. Lanar, et al.
Impact of Recombinant Adenovirus Serotype 35 Priming versus Boosting of a Plasmodium falciparum Protein: Characterization of T- and B-Cell Responses to Liver-Stage Antigen 1
Infect. Immun., April 1, 2008; 76(4): 1709 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. Chentoufi, X. Zhang, K. Lamberth, G. Dasgupta, I. Bettahi, A. Nguyen, M. Wu, X. Zhu, A. Mohebbi, S. Buus, et al.
HLA-A*0201-Restricted CD8+ Cytotoxic T Lymphocyte Epitopes Identified from Herpes Simplex Virus Glycoprotein D
J. Immunol., January 1, 2008; 180(1): 426 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Brando, L. A. Ware, H. Freyberger, A. Kathcart, A. Barbosa, S. Cayphas, M.-A. Demoitie, P. Mettens, D. G. Heppner, and D. E. Lanar
Murine Immune Responses to Liver-Stage Antigen 1 Protein FMP011, a Malaria Vaccine Candidate, Delivered with Adjuvant AS01B or AS02A
Infect. Immun., February 1, 2007; 75(2): 838 - 845.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
J. E. Garcia, A. Puentes, and M. E. Patarroyo
Developmental Biology of Sporozoite-Host Interactions in Plasmodium falciparum Malaria: Implications for Vaccine Design
Clin. Microbiol. Rev., October 1, 2006; 19(4): 686 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
E. ORLANDI-PRADINES, K. PENHOAT, C. DURAND, C. PONS, C. BAY, B. PRADINES, T. FUSAI, R. JOSSE, P. DUBROUS, J.-B. MEYNARD, et al.
ANTIBODY RESPONSES TO SEVERAL MALARIA PRE-ERYTHROCYTIC ANTIGENS AS A MARKER OF MALARIA EXPOSURE AMONG TRAVELERS
Am J Trop Med Hyg, June 1, 2006; 74(6): 979 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
C. C. JOHN, A. M. MOORMANN, D. C. PREGIBON, P. O. SUMBA, M. M. MCHUGH, D. L. NARUM, D. E. LANAR, M. D. SCHLUCHTER, and J. W. KAZURA
CORRELATION OF HIGH LEVELS OF ANTIBODIES TO MULTIPLE PRE-ERYTHROCYTIC PLASMODIUM FALCIPARUM ANTIGENS AND PROTECTION FROM INFECTION
Am J Trop Med Hyg, July 1, 2005; 73(1): 222 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. J. Hillier, L. A. Ware, A. Barbosa, E. Angov, J. A. Lyon, D. G. Heppner, and D. E. Lanar
Process Development and Analysis of Liver-Stage Antigen 1, a Preerythrocyte-Stage Protein-Based Vaccine for Plasmodium falciparum
Infect. Immun., April 1, 2005; 73(4): 2109 - 2115.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Prieur, S. C. Gilbert, J. Schneider, A. C. Moore, E. G. Sheu, N. Goonetilleke, K. J. H. Robson, and A. V. S. Hill
A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses
PNAS, January 6, 2004; 101(1): 290 - 295.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Saeftel, A. Krueger, S. Arriens, V. Heussler, P. Racz, B. Fleischer, F. Brombacher, and A. Hoerauf
Mice Deficient in Interleukin-4 (IL-4) or IL-4 Receptor {alpha} Have Higher Resistance to Sporozoite Infection with Plasmodium berghei (ANKA) than Do Naive Wild-Type Mice
Infect. Immun., January 1, 2004; 72(1): 322 - 331.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. BenMohamed, G. Bertrand, C. D. McNamara, H. Gras-Masse, J. Hammer, S. L. Wechsler, and A. B. Nesburn
Identification of Novel Immunodominant CD4+ Th1-Type T-Cell Peptide Epitopes from Herpes Simplex Virus Glycoprotein D That Confer Protective Immunity
J. Virol., September 1, 2003; 77(17): 9463 - 9473.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. C. John, J. S. Zickafoose, P. O. Sumba, C. L. King, and J. W. Kazura
Antibodies to the Plasmodium falciparum Antigens Circumsporozoite Protein, Thrombospondin-Related Adhesive Protein, and Liver-Stage Antigen 1 Vary by Ages of Subjects and by Season in a Highland Area of Kenya
Infect. Immun., August 1, 2003; 71(8): 4320 - 4325.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. K. KARIUKI, F. O. TER KUILE, K. WANNEMUEHLER, D. J. TERLOUW, M. S. KOLCZAK, W. A. HAWLEY, P. A. PHILLIPS-HOWARD, A. S. S. ORAGO, B. L. NAHLEN, A. A. LAL, et al.
EFFECTS OF PERMETHRIN-TREATED BED NETS ON IMMUNITY TO MALARIA IN WESTERN KENYA I. ANTIBODY RESPONSES IN PREGNANT WOMEN AND CORD BLOOD IN AN AREA OF INTENSE MALARIA TRANSMISSION
Am J Trop Med Hyg, April 1, 2003; 68(90040): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. L. King, I. Malhotra, A. Wamachi, J. Kioko, P. Mungai, S. A. Wahab, D. Koech, P. Zimmerman, J. Ouma, and J. W. Kazura
Acquired Immune Responses to Plasmodium falciparum Merozoite Surface Protein-1 in the Human Fetus
J. Immunol., January 1, 2002; 168(1): 356 - 364.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Theisen, D. Dodoo, A. Toure-Balde, S. Soe, G. Corradin, K. K. Koram, J. A. L. Kurtzhals, L. Hviid, T. Theander, B. Akanmori, et al.
Selection of Glutamate-Rich Protein Long Synthetic Peptides for Vaccine Development: Antigenicity and Relationship with Clinical Protection and Immunogenicity
Infect. Immun., September 1, 2001; 69(9): 5223 - 5229.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. C. John, P. O. Sumba, J. H. Ouma, B. L. Nahlen, C. L. King, and J. W. Kazura
Cytokine Responses to Plasmodium falciparum Liver-Stage Antigen 1 Vary in Rainy and Dry Seasons in Highland Kenya
Infect. Immun., September 1, 2000; 68(9): 5198 - 5204.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. L. Doolan, S. Southwood, R. Chesnut, E. Appella, E. Gomez, A. Richards, Y. I. Higashimoto, A. Maewal, J. Sidney, R. A. Gramzinski, et al.
HLA-DR-Promiscuous T Cell Epitopes from Plasmodium falciparum Pre-Erythrocytic-Stage Antigens Restricted by Multiple HLA Class II Alleles
J. Immunol., July 15, 2000; 165(2): 1123 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. K. Joshi, A. Bharadwaj, S. Chatterjee, and V. S. Chauhan
Analysis of Immune Responses against T- and B-Cell Epitopes from Plasmodium falciparum Liver-Stage Antigen 1 in Rodent Malaria Models and Malaria-Exposed Human Subjects in India
Infect. Immun., January 1, 2000; 68(1): 141 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. D. Kurtis, D. E. Lanar, M. Opollo, and P. E. Duffy
Interleukin-10 Responses to Liver-Stage Antigen 1 Predict Human Resistance to Plasmodium falciparum
Infect. Immun., July 1, 1999; 67(7): 3424 - 3429.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. L. Perlaza, M. Arevalo-Herrera, K. Brahimi, G. Quintero, J. C. Palomino, H. Gras-Masse, A. Tartar, P. Druilhe, and S. Herrera
Immunogenicity of Four Plasmodium falciparum Preerythrocytic Antigens in Aotus lemurinus Monkeys
Infect. Immun., July 1, 1998; 66(7): 3423 - 3428.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. A. Escalante, A. A. Lal, and F. J. Ayala
Genetic Polymorphism and Natural Selection in the Malaria Parasite Plasmodium falciparum
Genetics, May 1, 1998; 149(1): 189 - 202.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.