The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Figueroa, F.
Right arrow Articles by Klein, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Figueroa, F.
Right arrow Articles by Klein, J.
Right arrowPubmed/NCBI databases
*Nucleotide*Protein

The Journal of Immunology, Vol 152, Issue 9 4455-4465, Copyright © 1994 by American Association of Immunologists

ARTICLES

The origin of the primate Mhc-DRB genes and allelic lineages as deduced from the study of prosimians

F Figueroa, C O'hUigin, H Tichy and J Klein
Max Planck Institute for Biology, Immunogenetics Department, Tubingen, Germany.

MHC class II genes of the DRB family were partially sequenced from 10 individuals representing six species of prosimians: Galago senegalensis, G. moholi, Otolemur garnetti, Loris tardigradus, Petterus (Lemur) fulvus, and Lemur catta. Altogether, 41 different genes were discerned, all distinct from genes identified previously. Comparative analysis of the sequences has led to the following conclusions. First, the DRB loci present in human populations diverged from one another before the divergence of prosimian and anthropoid primates. Second, major allelic lineages of the DRB1 locus, such as DRB1*03 (DRB1*13) and DRB1*04, were established more than 85 million years ago. Third, the DRB6 gene was inactivated before the separation of prosimians and anthropoids, and has remained a pseudogene for more than 85 million years. Fourth, the primate DRB region is structurally and functionally unstable. In Lemur catta, for example, all DRB genes have apparently been lost and their function taken over by DOB and/or DPB genes. DRB genes are, however, present in a related species, Petterus (Lemur) fulvus. Fifth, the prosimian DRB3 genes are all inactive; their function seems to have been taken over by new genes. Sixth, several of the prosimian DRB genes and pseudogenes have recently been duplicated. In Otolemur garnetti, for example, one chromosome carries at least three copies of the DRB3 pseudogene.


This article has been cited by other articles:


Home page
 Genome ResHome page
K. Kriener, C. O'hUigin, and J. Klein
Alu Elements Support Independent Origin of Prosimian, Platyrrhine, and Catarrhine Mhc-DRB Genes
Genome Res., May 1, 2000; 10(5): 634 - 643.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
G. G. M. Doxiadis, N. Otting, N. G. de Groot, R. Noort, and R. E. Bontrop
Unprecedented Polymorphism of Mhc-DRB Region Configurations in Rhesus Macaques
J. Immunol., March 15, 2000; 164(6): 3193 - 3199.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Su and M. Nei
Fifty-million-year-old polymorphism at an immunoglobulin variable region gene locus in the rabbit evolutionary lineage
PNAS, August 17, 1999; 96(17): 9710 - 9715.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.