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The Journal of Immunology, Vol 152, Issue 9 4262-4269, Copyright © 1994 by American Association of Immunologists
ARTICLES |
WC Fanslow, KN Clifford, M Seaman, MR Alderson, MK Spriggs, RJ Armitage and F Ramsdell
Immunex Research and Development Corporation, Seattle, WA 98101.
Murine and human CD40 ligand (CD40L) were recently cloned, expressed, and shown to possess potent activity on human and murine B cells, including stimulation of proliferation and Ig secretion in the presence of cytokines. In addition to its action on B lymphocytes, this report demonstrates that CD40L induced both CD4+ and CD8+ T cells isolated from murine lymphoid tissues to proliferate in the presence of submitogenic dosages of Con A, PHA, CD3 mAb, and TCR-alpha beta mAb. The presence of CD40L during suboptimal TCR stimulation resulted in increased expression of the activation Ags IL-2R alpha and CD69 and increased IL-2 production. Taken together, these results show that CD40L is a potent activator of murine T cells and suggest that CD40L is involved in the regulation of T cell function mediated through T:T cell interaction.
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