The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Slierendregt, B. L.
Right arrow Articles by Bontrop, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Slierendregt, B. L.
Right arrow Articles by Bontrop, R. E.

The Journal of Immunology, Vol 152, Issue 5 2298-2307, Copyright © 1994 by American Association of Immunologists

ARTICLES

Expansion and contraction of rhesus macaque DRB regions by duplication and deletion

BL Slierendregt, N Otting, N van Besouw, M Jonker and RE Bontrop
Tegepast Natuurwetenschappelyk Onclerzoek, Department of Chronic and Infectious Diseases, Rijswijk, The Netherlands.

Previous sequence analysis of the rhesus macaque MHC (MhcMamu) class II DRB region has allowed the detection of at least 34 alleles belonging to different lineages. In this communication, 36 new Mamu-DRB alleles are reported. The gene content of the DRB region has been determined for several homozygous animals of consanguineous origin. As in other primates, the number of DRB genes present per haplotype is not constant, varying from two to six genes in rhesus macaques. Six major groups of DRB haplotypes have been defined in our rhesus macaque colony. Two haplotype groups were found to carry, as well as other Mamu- DRB genes, two genes that cluster into distinct HLA-DRB1 lineages. In one of these two groups, a haplotype harbors another two sets of DRB alleles that belong to the Mhc-DRB6 and -DRB*W6 lineages, respectively. Such a haplotype was probably generated by duplication, and our data suggest that after this particular expansion of the DR region, one of the duplicated Mamu-DRB6 alleles was the target of an Alu insertion. Although certain transspecies allelic lineages are evolutionarily stable, and have been conserved for at least 36 million years, the rhesus macaque class II haplotypes differ significantly from those found in humans, chimpanzees, and gorillas. Mhc-DRB regions are therefore comparatively unstable over longer evolutionary time spans, with regard to both the number of genes and the gene content, and must have been subjected to expansion and contraction.


This article has been cited by other articles:


Home page
 J. Virol.Home page
G. G. M. Doxiadis, N. de Groot, and R. E. Bontrop
Impact of Endogenous Intronic Retroviruses on Major Histocompatibility Complex Class II Diversity and Stability
J. Virol., July 1, 2008; 82(13): 6667 - 6677.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. S. Lee, M. Gutierrez-Arcelus, G. H. Perry, E. J. Vallender, W. E. Johnson, G. M. Miller, J. O. Korbel, and C. Lee
Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies
Hum. Mol. Genet., April 15, 2008; 17(8): 1127 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. G. M. Doxiadis, N. de Groot, F. H. J. Claas, I. I. N. Doxiadis, J. J. van Rood, and R. E. Bontrop
A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques
PNAS, May 22, 2007; 104(21): 8907 - 8912.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. G. M. Doxiadis, M. K. H. van der Wiel, H. P. M. Brok, N. G. de Groot, N. Otting, B. A. 't Hart, J. J. van Rood, and R. E. Bontrop
Reactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species
PNAS, April 11, 2006; 103(15): 5864 - 5868.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
R. Daza-Vamenta, G. Glusman, L. Rowen, B. Guthrie, and D. E. Geraghty
Genetic Divergence of the Rhesus Macaque Major Histocompatibility Complex
Genome Res., August 1, 2004; 14(8): 1501 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. de Groot, G. G. Doxiadis, N. G. de Groot, N. Otting, C. Heijmans, A. J. M. Rouweler, and R. E. Bontrop
Genetic Makeup of the DR Region in Rhesus Macaques: Gene Content, Transcripts, and Pseudogenes
J. Immunol., May 15, 2004; 172(10): 6152 - 6157.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sarkar, V. Kalia, M. Murphey-Corb, and R. C. Montelaro
Detailed Analysis of CD4+ Th Responses to Envelope and Gag Proteins of Simian Immunodeficiency Virus Reveals an Exclusion of Broadly Reactive Th Epitopes from the Glycosylated Regions of Envelope
J. Immunol., April 15, 2002; 168(8): 4001 - 4011.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. G. M. Doxiadis, N. Otting, N. G. de Groot, R. Noort, and R. E. Bontrop
Unprecedented Polymorphism of Mhc-DRB Region Configurations in Rhesus Macaques
J. Immunol., March 15, 2000; 164(6): 3193 - 3199.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. G. Antunes, N. G. de Groot, H. Brok, G. Doxiadis, A. A. L. Menezes, N. Otting, and R. E. Bontrop
The common marmoset: A new world primate species with limited Mhc class II variability
PNAS, September 29, 1998; 95(20): 11745 - 11750.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.