The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vicari, A.
Right arrow Articles by Tucek, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vicari, A.
Right arrow Articles by Tucek, C. L.

The Journal of Immunology, Vol 152, Issue 5 2207-2213, Copyright © 1994 by American Association of Immunologists

ARTICLES

MTS-32 monoclonal antibody defines CD4+8- thymocyte subsets that differ in their maturation level, lymphokine secretion, and selection patterns

A Vicari, O Abehsira-Amar, M Papiernik, RL Boyd and CL Tucek
INSERM U 345, Necker Institute, Paris, France.

We have previously described MTS-32 as identifying an Ag on both thymic stromal cells and thymocytes. In contrast with CD4+8+ and CD4-8+ thymocytes, of which the vast majority are MTS-32+, a notable subset of CD4+8- thymocytes is MTS-32-. Here we show that with regard to heat- stable Ags, Qa-2, and CD69 expression CD4+8- MTS-32- thymocytes are phenotypically enriched in mature cells when compared with their MTS- 32+ counterparts. Moreover, sorted CD4+8- MTS-32+ thymocytes are unable to respond to anti-CD3 cross-linking, whereas MTS-32- CD4+8- thymocytes respond to the same stimulus by producing IL-4, IL-5, IL-10, IFN-gamma, and trace amounts of IL-2. In addition, MTS-32- CD4+8- and CD4-8- TCR- alpha beta+ thymocytes differ in their TCR V beta repertoire on a Mls- 1a selecting background. We therefore suggest that the MTS-32 ligand is involved in signals consecutive with TCR recognition in the thymus, i.e., selection, activation, and lymphokine production.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
R. Jin, W. Wang, J.-Y. Yao, Y.-B. Zhou, X.-P. Qian, J. Zhang, Y. Zhang, and W.-F. Chen
Characterization of the In Vivo Dynamics of Medullary CD4+CD8- Thymocyte Development
J. Immunol., February 15, 2008; 180(4): 2256 - 2263.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Li, Y. Li, J.-Y. Yao, R. Jin, M.-Z. Zhu, X.-P. Qian, J. Zhang, Y.-X. Fu, L. Wu, Y. Zhang, et al.
Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice
PNAS, November 13, 2007; 104(46): 18175 - 18180.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. Tian, J. Zhang, L. Gao, X. P. Qian, and W.-F. Chen
Heterogeneity within medullary-type TCR{{alpha}}{beta}+CD3+CD4-CD8+ thymocytes in normal mouse thymus
Int. Immunol., March 1, 2001; 13(3): 313 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
Q. Ge and W.-F. Chen
Effect of murine thymic epithelial cell line (MTEC1) on the functional expression of CD4+CD8- thymocyte subgroups
Int. Immunol., August 1, 2000; 12(8): 1127 - 1133.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.