| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 152, Issue 12 5969-5978, Copyright © 1994 by American Association of Immunologists
ARTICLES |
C Faveeuw, MC Gagnerault and F Lepault
National Center for Scientific Research (CNRS URA 1461), Necker Hospital, Paris, France.
The nonobese diabetic mouse is a relevant model for insulin-dependent diabetes mellitus which results from the destruction of pancreatic beta cells by mononuclear cells infiltrating the islets of Langerhans. Other organs such as salivary glands display inflammatory infiltration. Using immunohistochemical and flow cytometry analyses, we have studied the expression of diverse homing and adhesion molecules in salivary glands and the pancreas in nonobese diabetic mice. In salivary glands, ICAM-1 was expressed by endothelial and dendritic cells within the lymphocytic infiltration. HEV-like structures expressing PNAd were observed in the areas of lymphocytic infiltration whereas MAdCAM-1 was absent. Lymphocytes infiltrating salivary glands expressed LFA-1 and Pgp-1 although Mel-14 Ag was absent. In infiltrated islets, ICAM-1 was expressed by endothelial cells, dendritic cells, and mononuclear cells. We confirm the presence of HEV-like structures expressing MAdCAM-1 and PNAd in inflamed islets. With regard to peripheral lymphocytes, the proportion of CD4 and CD8 cells expressing Mel-14 was decreased in the infiltrated islets, whereas the expression of LFA-1, Pgp-1, and LPAM- 1/2 was increased. B lymphocytes exhibited up-regulation of LPAM-1/2. Moreover, the proportion of CD4, CD8, and B lymphocytes expressing CD69 was increased in the pancreas. These results indicate that first, infiltration of islets of Langerhans results at least partly from modifications of adhesion molecule expression in the pancreas, which allow extravasation of mononuclear cells into the islets via at least three different pathways; and second, that activated cells are concentrated in the infiltrates as compared with peripheral lymphoid organs.
This article has been cited by other articles:
|
|
 |
|
  N. Hiraoka, B. Petryniak, H. Kawashima, J. Mitoma, T. O Akama, M. N Fukuda, J. B Lowe, and M. Fukuda Significant decrease in {alpha}1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing Glycobiology, March 1, 2007; 17(3): 277 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Heikenwalder, N. Zeller, H. Seeger, M. Prinz, P.-C. Klohn, P. Schwarz, N. H. Ruddle, C. Weissmann, and A. Aguzzi Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions Science, February 18, 2005; 307(5712): 1107 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rivera-Nieves, T. Olson, G. Bamias, A. Bruce, M. Solga, R. F. Knight, S. Hoang, F. Cominelli, and K. Ley L-Selectin, {alpha}4{beta}1, and {alpha}4{beta}7 Integrins Participate in CD4+ T Cell Recruitment to Chronically Inflamed Small Intestine J. Immunol., February 15, 2005; 174(4): 2343 - 2352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Huang, K. Matthews, T. J. Siahaan, and C. G. Kevil {alpha}L-Integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G67 - G73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bistrup, D. Tsay, P. Shenoy, M. S. Singer, N. Bangia, S. A. Luther, J. G. Cyster, N. H. Ruddle, and S. D. Rosen Detection of a Sulfotransferase (HEC-GlcNAc6ST) in High Endothelial Venules of Lymph Nodes and in High Endothelial Venule-Like Vessels within Ectopic Lymphoid Aggregates: Relationship to the MECA-79 Epitope Am. J. Pathol., May 1, 2004; 164(5): 1635 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Voon, L. S. Subrata, M. Karimi, D. Ulgiati, and L. J. Abraham TNF and Phorbol Esters Induce Lymphotoxin-{beta} Expression through Distinct Pathways Involving Ets and NF-{kappa}B Family Members J. Immunol., April 1, 2004; 172(7): 4332 - 4341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hiraoka, H. Kawashima, B. Petryniak, J. Nakayama, J. Mitoma, J. D. Marth, J. B. Lowe, and M. Fukuda Core 2 Branching {beta}1,6-N-Acetylglucosaminyltransferase and High Endothelial Venule-restricted Sulfotransferase Collaboratively Control Lymphocyte Homing J. Biol. Chem., January 23, 2004; 279(4): 3058 - 3067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Drayton, X. Ying, J. Lee, W. Lesslauer, and N. H. Ruddle Ectopic LT{alpha}{beta} Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase J. Exp. Med., May 5, 2003; 197(9): 1153 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tu, J. C. Poe, T. Kadono, G. M. Venturi, D. C. Bullard, T. F. Tedder, and D. A. Steeber A Functional Role for Circulating Mouse L-Selectin in Regulating Leukocyte/Endothelial Cell Interactions In Vivo J. Immunol., August 15, 2002; 169(4): 2034 - 2043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Gagnerault, J. J. Luan, C. Lotton, and F. Lepault Pancreatic Lymph Nodes Are Required for Priming of {beta} Cell Reactive T Cells in NOD Mice J. Exp. Med., August 5, 2002; 196(3): 369 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Friedline, C. P. Wong, D. A. Steeber, T. F. Tedder, and R. Tisch L-Selectin Is Not Required for T Cell-Mediated Autoimmune Diabetes J. Immunol., March 15, 2002; 168(6): 2659 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Katakai, K. J. Mori, T. Masuda, and A. Shimizu Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or {alpha}4{beta}7-integrin at the lesions of autoimmune gastritis Int. Immunol., February 1, 2002; 14(2): 167 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. L. Chiu, A. M. Jevnikar, and J. S. Danska Genetic Control of T and B Lymphocyte Activation in Nonobese Diabetic Mice J. Immunol., December 15, 2001; 167(12): 7169 - 7179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kommajosyula, S. Reddy, K. Nitschke, J. R. Kanwar, M. Karanam, and G. W. Krissansen Leukocytes infiltrating the pancreatic islets of nonobese diabetic mice are transformed into inactive exiles by combinational anti-cell adhesion therapy J. Leukoc. Biol., October 1, 2001; 70(4): 510 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mikulowska-Mennis, B. Xu, J. M. Berberian, and S. A. Michie Lymphocyte Migration to Inflamed Lacrimal Glands Is Mediated by Vascular Cell Adhesion Molecule-1/{alpha}4{beta}1 Integrin, Peripheral Node Addressin/L-Selectin, and Lymphocyte Function-Associated Antigen-1 Adhesion Pathways Am. J. Pathol., August 1, 2001; 159(2): 671 - 681. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Yamamoto, Y. Chernajovsky, F. Lepault, O. Podhajcer, M. Feldmann, J.-F. Bach, and L. Chatenoud The Activity of Immunoregulatory T Cells Mediating Active Tolerance Is Potentiated in Nonobese Diabetic Mice by an IL-4-Based Retroviral Gene Therapy J. Immunol., April 15, 2001; 166(8): 4973 - 4980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kato, R. Hokari, K. Matsuzaki, A. Iwai, A. Kawaguchi, S. Nagao, T. Miyahara, K. Itoh, H. Ishii, and S. Miura Amelioration of Murine Experimental Colitis by Inhibition of Mucosal Addressin Cell Adhesion Molecule-1 J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 183 - 189. [Abstract] [Full Text]
|
|
|
|
|
|
N. Ruiz-Velasco, M. Guerrero-Esteo, M. J. Briskin, and J. Teixido The alpha 4 Integrin Subunit Tyr187 Has a Key Role in alpha 4beta 7-Dependent Cell Adhesion J. Biol. Chem., March 15, 2000; 275(10): 7052 - 7059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Weiss, S. Slavin, S. Reich, P. Cohen, S. Shuster, R. Stern, E. Kaganovsky, E. Okon, A. M. Rubinstein, and D. Naor Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody PNAS, January 4, 2000; 97(1): 285 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Rosen Endothelial Ligands for L-Selectin : From Lymphocyte Recirculation to Allograft Rejection Am. J. Pathol., October 1, 1999; 155(4): 1013 - 1020. [Full Text] [PDF]
|
|
|
|
|
|
C. A. Cuff, R. Sacca, and N. H. Ruddle Differential Induction of Adhesion Molecule and Chemokine Expression by LT{alpha}3 and LT{alpha}{beta} in Inflammation Elucidates Potential Mechanisms of Mesenteric and Peripheral Lymph Node Development J. Immunol., May 15, 1999; 162(10): 5965 - 5972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Bradley, V. C. Asensio, L.-K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes J. Immunol., March 1, 1999; 162(5): 2511 - 2520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Cuff, J. Schwartz, C. M. Bergman, K. S. Russell, J. R. Bender, and N. H. Ruddle Lymphotoxin {alpha}3 Induces Chemokines and Adhesion Molecules: Insight into the Role of LT{alpha} in Inflammation and Lymphoid Organ Development J. Immunol., December 15, 1998; 161(12): 6853 - 6860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hanninen, I. Jaakkola, and S. Jalkanen Mucosal Addressin Is Required for the Development of Diabetes in Nonobese Diabetic Mice J. Immunol., June 15, 1998; 160(12): 6018 - 6025. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
