The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moskophidis, D.
Right arrow Articles by Zinkernagel, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moskophidis, D.
Right arrow Articles by Zinkernagel, R. M.

The Journal of Immunology, Vol 152, Issue 10 4976-4983, Copyright © 1994 by American Association of Immunologists

ARTICLES

MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice

D Moskophidis, F Lechner, H Hengartner and RM Zinkernagel
Department of Pathology, University of Zurich, Switzerland.

The influence of the murine MHC gene complex H-2 class I alleles or of the genetic background and the role of virus variants on establishment of a persistent infection with lymphocytic choriomeningitis virus (LCMV) was analyzed in immunocompetent mice of H-2d haplotype by evaluation of cytotoxic T cell responses. Susceptibility to establishment of a virus carrier state increased in various H-2d mice with lower CTL response and slower CTL kinetics. Low responder BALB/c-H- 2dm2, lacking H-2Ld molecules to present the major T cell epitope amino acids 118-126 of the LCMV nucleoprotein or DBA/2 mice possessing relatively few CD8+ T cells, were more susceptible than high responder BALB/c mice expressing H-2Ld. Additional critical factors were LCMV isolate and dose of infection. The rapidly replicating LCMV-DOCILE and Cl 13 Armstrong induced viral persistence readily, whereas the slowly replicating parental virus strains WE or Armstrong did not. The presented findings illustrate a model of MHC-linked or MHC-unlinked susceptibility for virus persistence and may help to explain pathogeneses of chronic virus infections in humans that are often associated with slowly progressing immunopathology.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
N. S. Butler, A. Theodossis, A. I. Webb, M. A. Dunstone, R. Nastovska, S. H. Ramarathinam, J. Rossjohn, A. W. Purcell, and S. Perlman
Structural and Biological Basis of CTL Escape in Coronavirus-Infected Mice
J. Immunol., March 15, 2008; 180(6): 3926 - 3937.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Hunziker, A. Ciurea, M. Recher, H. Hengartner, and R. M. Zinkernagel
Public versus personal serotypes of a viral quasispecies
PNAS, May 13, 2003; 100(10): 6015 - 6020.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
I. Messaoudi, J. A. G. Patino, R. Dyall, J. LeMaoult, and J. Nikolich-Žugich
Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense
Science, November 29, 2002; 298(5599): 1797 - 1800.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
N. N. Kristensen, J. P. Christensen, and A. R. Thomsen
High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development
J. Gen. Virol., September 1, 2002; 83(9): 2123 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
W. V. Bonilla, D. D. Pinschewer, P. Klenerman, V. Rousson, M. Gaboli, P. P. Pandolfi, R. M. Zinkernagel, M. S. Salvato, and H. Hengartner
Effects of Promyelocytic Leukemia Protein on Virus-Host Balance
J. Virol., March 19, 2002; 76(8): 3810 - 3818.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Ou, S. Zhou, L. Huang, and D. Moskophidis
Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells
J. Virol., September 15, 2001; 75(18): 8407 - 8423.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. P. Christensen, C. Bartholdy, D. Wodarz, and A. R. Thomsen
Depletion of CD4+ T Cells Precipitates Immunopathology in Immunodeficient Mice Infected with a Noncytocidal Virus
J. Immunol., March 1, 2001; 166(5): 3384 - 3391.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Bartholdy, J. P. Christensen, D. Wodarz, and A. R. Thomsen
Persistent Virus Infection despite Chronic Cytotoxic T-Lymphocyte Activation in Gamma Interferon-Deficient Mice Infected with Lymphocytic Choriomeningitis Virus
J. Virol., November 15, 2000; 74(22): 10304 - 10311.
[Abstract] [Full Text]

Home page
 J. Exp. Med.Home page
F. Lechner, D. K.H. Wong, P. R. Dunbar, R. Chapman, R. T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, and B. D. Walker
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
J. Exp. Med., May 1, 2000; 191(9): 1499 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. T. Lin, D. R. Hinton, N. W. Marten, C. C. Bergmann, and S. A. Stohlman
Antibody Prevents Virus Reactivation Within the Central Nervous System
J. Immunol., June 15, 1999; 162(12): 7358 - 7368.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1994 by The American Association of Immunologists, Inc. All rights reserved.