| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 151, Issue 8 4183-4188, Copyright © 1993 by American Association of Immunologists
ARTICLES |
J Abe, T Takeda, Y Watanabe, H Nakao, N Kobayashi, DY Leung and T Kohsaka
Department of Allergy and Immunology, National Children's Medical Research Center, Tokyo, Japan.
Yersinia pseudotuberculosis is an enteric pathogen that induces a variety of clinical symptoms, fever, scarlatiniform rash, diarrhea, vomiting, and arthritis. Characteristic histopathologic findings in Y. pseudotuberculosis infection such as lymphoid hyperplasia, typically seen in mesenteric lymph nodes, suggest that the stimulation of a large proportion of T lymphocytes may be involved in the pathogenesis of this infection. In this study, we assessed the mitogenic activity of culture supernatants of the clinical isolates of Y. pseudotuberculosis and investigated the mechanism by which these culture sups activate T cells. The culture sups, as well as partially purified fractions obtained by gel filtration, were found to selectively stimulate T cells bearing V beta 3, V beta 9, V beta 13.1, and V beta 13.2 compared with stimulation by anti-CD3. Furthermore, fibroblasts transfected with different HLA class II molecules, either HLA-DPw9, -DQw6, -DR1, or -DR4 Dw15, were capable of presenting Y. pseudotuberculosis culture supernatants to purified T cells. The T cell response to this sup was not restricted by donor HLA-DR types and was not neutralized by antibodies against the known staphylococcal superantigens, Staphylococcal enterotoxin (SE)A, SEB, SEC2, SED, SEE, and TSST1. These results suggest that Y. pseudotuberculosis produces superantigenic toxins that may mediate some of the systemic illnesses associated with infection by this organism.
This article has been cited by other articles:
|
|
 |
|
  F. Collyn, H. Fukushima, C. Carnoy, M. Simonet, and P. Vincent Linkage of the Horizontally Acquired ypm and pil Genes in Yersinia pseudotuberculosis Infect. Immun., April 1, 2005; 73(4): 2556 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Cooper, M. T. Orr, C. J. McMahan, and P. J. Fink T Cell Receptor Revision Does Not Solely Target Recent Thymic Emigrants J. Immunol., July 1, 2003; 171(1): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Carnoy, S. Floquet, M. Marceau, F. Sebbane, S. Haentjens-Herwegh, A. Devalckenaere, and M. Simonet The Superantigen Gene ypm Is Located in an Unstable Chromosomal Locus of Yersinia pseudotuberculosis J. Bacteriol., August 15, 2002; 184(16): 4489 - 4499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, M. Koyanagi, K. Fukada, K.'i. Imanishi, J. Yagi, H. Kato, T. Miyoshi-Akiyama, R. Zhang, K. Miwa, and T. Uchiyama Continuous Exposure of Mice to Superantigenic Toxins Induces a High-Level Protracted Expansion and an Immunological Memory in the Toxin-Reactive CD4+ T Cells J. Immunol., April 15, 2002; 168(8): 3817 - 3824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Huang, R. Golub, G. E. Wu, and O. Kanagawa Superantigen-Induced TCR {alpha} Locus Secondary Rearrangement: Role in Tolerance Induction J. Immunol., April 1, 2002; 168(7): 3259 - 3265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fukushima, Y. Matsuda, R. Seki, M. Tsubokura, N. Takeda, F. N. Shubin, I. K. Paik, and X. B. Zheng Geographical Heterogeneity between Far Eastern and Western Countries in Prevalence of the Virulence Plasmid, the Superantigen Yersinia pseudotuberculosis-Derived Mitogen, and the High-Pathogenicity Island among Yersinia pseudotuberculosis Strains J. Clin. Microbiol., October 1, 2001; 39(10): 3541 - 3547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Carnoy, C. Mullet, H. Muller-Alouf, E. Leteurtre, and M. Simonet Superantigen YPMa Exacerbates the Virulence of Yersinia pseudotuberculosis in Mice Infect. Immun., May 1, 2000; 68(5): 2553 - 2559. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
