The Journal of Immunology, Vol 151, Issue 5 2521-2528, Copyright © 1993 by American Association of Immunologists

ARTICLES

Properdin, a positive regulator of complement activation, is expressed in human T cell lines and peripheral blood T cells

W Schwaeble, WG Dippold, MK Schafer, H Pohla, D Jonas, B Luttig, E Weihe, HP Huemer, MP Dierich and KB Reid
I. Medical Clinic, University of Mainz, Germany.

Properdin plays an important regulatory role in the activation of the complement system. Here we report the biosynthesis of properdin in four different human T cell lines and in T cells purified from peripheral blood. Cell sorting experiments, in conjunction with Northern blotting, showed that both CD4- and CD8-bearing populations of T cells have the potential to synthesize properdin. The functional activity of properdin secreted from these T cell lines was determined in a hemolytic assay. In view of the numerous ways in which complement activation may influence cellular immune response, the present results indicate, for the first time, a possible interaction between the complement and the T cell system.

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