| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 151, Issue 5 2497-2510, Copyright © 1993 by American Association of Immunologists
ARTICLES |
M Roy, T Waldschmidt, A Aruffo, JA Ledbetter and RJ Noelle
Graduate Program in Biochemistry, Dartmouth Medical School, Lebanon, NH 03756.
Studies have established that gp39, the ligand for CD40, induces B cell cycle entry and is involved in the initiation of the humoral immune response. Expression of gp39 has been observed on normal, activated CD4+ T cells, activated lymph node cells; an activated Th1 clone, and an activated Th2 clone. Anti-CD3-activated CD8+ T cells did not express gp39; however, CD8+ T cells activated with PMA/ionomycin expressed gp39. The kinetics of anti-CD3-induced gp39 expression on a T cell clone and on splenic CD4+ T cells showed that gp39 was detectable at 4 h after activation, reaching maximal levels between 6 to 8 h postactivation and returning to near resting levels between 24 to 48 h. Lymphokines modulated the expression of gp39 on activated T cells. Expression of gp39 was inhibited by IFN-gamma on activated Th1, Th2, and CD4+ T cells; whereas TGF-beta inhibited gp39 expression only on the Th2 clone studied. All other lymphokines tested were without substantial effect. Differences in the expression of gp39 on activated naive and memory T cells were observed, as well as differences in requirements for optimal gp39 expression on these subsets. There are correlations between gp39 expression and effector function; however, anti-CD3-activated splenic CD4+ cells that express gp39 did not exhibit effector function. A comparison of the relative numbers of molecules of gp39 shows that activated Th1 clones express at least 20-fold the number of gp39 molecules/cell compared with activated splenic CD4+ cells. This may imply that density of gp39 on the activated T cells plays an important role in determining effector function.
This article has been cited by other articles:
|
|
 |
|
  H. Xu, Y. Huang, P. M. Chilton, L.-R. Hussain, M. K. Tanner, J. Yan, and S. T. Ildstad Strategic Nonmyeloablative Conditioning: CD154:CD40 Costimulatory Blockade at Primary Bone Marrow Transplantation Promotes Engraftment for Secondary Bone Marrow Transplantation after Engraftment Failure J. Immunol., November 1, 2008; 181(9): 6616 - 6624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. B. Lineberry, L. L. Su, J. T. Lin, G. P. Coffey, C. M. Seroogy, and C. G. Fathman Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy J. Immunol., August 1, 2008; 181(3): 1622 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Martinez-Gallo, C. Puy, R. Ruiz-Hernandez, J. M. Rodriguez-Arias, M. Bofill, J. F. Nomdedeu, J. C. Cigudosa, J. L. Rodriguez-Sanchez, and O. de la Calle-Martin Severe and recurrent episodes of bronchiolitis obliterans organising pneumonia associated with indolent CD4+ CD8+ T-cell leukaemia Eur. Respir. J., June 1, 2008; 31(6): 1368 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lorenzo, M. Horowitz, and Y. Choi Osteoimmunology: Interactions of the Bone and Immune System Endocr. Rev., June 1, 2008; 29(4): 403 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Xu, J. Yan, Y. Huang, P. M. Chilton, C. Ding, C. L. Schanie, L. Wang, and S. T. Ildstad Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization Blood, March 15, 2008; 111(6): 3266 - 3275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Setoguchi, M. Tachibana, Y. Naoe, S. Muroi, K. Akiyama, C. Tezuka, T. Okuda, and I. Taniuchi Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development Science, February 8, 2008; 319(5864): 822 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hanig and M. B. Lutz Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing J. Immunol., February 1, 2008; 180(3): 1405 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sun and P. J. Fink A New Class of Reverse Signaling Costimulators Belongs to the TNF Family J. Immunol., October 1, 2007; 179(7): 4307 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Liu, A. Guardino, L. Chinsangaram, M. J. Goldstein, D. Panicali, and R. Levy Therapeutic Vaccination against Murine Lymphoma by Intratumoral Injection of Recombinant Fowlpox Virus Encoding CD40 Ligand Cancer Res., July 15, 2007; 67(14): 7037 - 7044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Arce, H. F. Nawar, G. Muehlinghaus, M. W. Russell, and T. D. Connell In Vitro Induction of Immunoglobulin A (IgA)- and IgM-Secreting Plasma Blasts by Cholera Toxin Depends on T-Cell Help and Is Mediated by CD154 Up-Regulation and Inhibition of Gamma Interferon Synthesis Infect. Immun., March 1, 2007; 75(3): 1413 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. H. Hernandez, L. Shen, and K. L. Rock CD40-CD40 Ligand Interaction between Dendritic Cells and CD8+ T Cells Is Needed to Stimulate Maximal T Cell Responses in the Absence of CD4+ T Cell Help J. Immunol., March 1, 2007; 178(5): 2844 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. H. G. Kessels, K. Schepers, M. D. van den Boom, D. J. Topham, and T. N. M. Schumacher Generation of T Cell Help through a MHC Class I-Restricted TCR J. Immunol., July 15, 2006; 177(2): 976 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lesley, L. M. Kelly, Y. Xu, and J. G. Cyster Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival PNAS, July 11, 2006; 103(28): 10717 - 10722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Mueller, C. M. Jones, A. T. Stock, M. Suter, W. R. Heath, and F. R. Carbone CD4+ T Cells Can Protect APC from CTL-Mediated Elimination. J. Immunol., June 15, 2006; 176(12): 7379 - 7384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bonardelle, K. Benihoud, N. Kiger, and P. Bobe B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice J. Leukoc. Biol., November 1, 2005; 78(5): 1052 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Chen, H.-W. Chang, C.-J. Wu, C.-H. Yang, W. C. Hung, K.-H. Yeh, and M. Fu Percutaneous Transluminal Mitral Valvuloplasty Reduces Circulating Soluble CD40 Ligand in Rheumatic Mitral Stenosis Chest, July 1, 2005; 128(1): 36 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Terrazzano, M. Sica, C. Becchimanzi, S. Costantini, B. Rotoli, S. Zappacosta, F. Alfinito, and G. Ruggiero T cells from paroxysmal nocturnal haemoglobinuria (PNH) patients show an altered CD40-dependent pathway J. Leukoc. Biol., July 1, 2005; 78(1): 27 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, C. Cuda, and L. Morel Genetic Determination of T Cell Help in Loss of Tolerance to Nuclear Antigens J. Immunol., June 15, 2005; 174(12): 7692 - 7702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Ildstad, P. M. Chilton, H. Xu, M. A. Domenick, and M. B. Ray Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of {alpha}{beta}-TCR+ and CD4+ cells negates the effect Blood, March 15, 2005; 105(6): 2577 - 2584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Smed-Sorensen, K. Lore, L. Walther-Jallow, J. Andersson, and A.-L. Spetz HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation Blood, November 1, 2004; 104(9): 2810 - 2817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Urban and S. Winandy Ikaros Null Mice Display Defects in T Cell Selection and CD4 versus CD8 Lineage Decisions J. Immunol., October 1, 2004; 173(7): 4470 - 4478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Boisvert, S. Edmondson, and M. F. Krummel Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites J. Immunol., September 15, 2004; 173(6): 3647 - 3652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Singh, J. Laughlin, P. A. Kosinski, and L. R. Covey Nucleolin Is a Second Component of the CD154 mRNA Stability Complex That Regulates mRNA Turnover in Activated T Cells J. Immunol., July 15, 2004; 173(2): 976 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Burger, N. Molnarfi, L. Gruaz, and J.-M. Dayer Differential Induction of IL-1{beta} and TNF by CD40 Ligand or Cellular Contact with Stimulated T Cells Depends on the Maturation Stage of Human Monocytes J. Immunol., July 15, 2004; 173(2): 1292 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kaufman, P. J. Sime, and R. P. Phipps Expression of CD154 (CD40 Ligand) by Human Lung Fibroblasts: Differential Regulation by IFN-{gamma} and IL-13, and Implications for Fibrosis J. Immunol., February 1, 2004; 172(3): 1862 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. O. Lee, J. Moyron-Quiroz, J. Rangel-Moreno, K. L. Kusser, L. Hartson, F. Sprague, F. E. Lund, and T. D. Randall CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses J. Immunol., December 1, 2003; 171(11): 5707 - 5717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Watanabe, H. Kagamu, H. Yoshizawa, N. Fujita, H. Tanaka, J. Tanaka, and F. Gejyo The Duration of Signaling through CD40 Directs Biological Ability of Dendritic Cells to Induce Antitumor Immunity J. Immunol., December 1, 2003; 171(11): 5828 - 5836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brandes, K. Willimann, A. B. Lang, K.-H. Nam, C. Jin, M. B. Brenner, C. T. Morita, and B. Moser Flexible migration program regulates {gamma}{delta} T-cell involvement in humoral immunity Blood, November 15, 2003; 102(10): 3693 - 3701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Fecteau and S. Neron CD40 Stimulation of Human Peripheral B Lymphocytes: Distinct Response from Naive and Memory Cells J. Immunol., November 1, 2003; 171(9): 4621 - 4629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wingett and C. P. Nielson Divergence in NK cell and cyclic AMP regulation of T cell CD40L expression in asthmatic subjects J. Leukoc. Biol., October 1, 2003; 74(4): 531 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Friedlander, C. L. Delaune, J. M. Abadie, M. Toups, J. LaCour, L. Marrero, Q. Zhong, and J. K. Kolls Efficacy of CD40 Ligand Gene Therapy in Malignant Mesothelioma Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 321 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, C. S. Schmidt, F. Zhao, A. J. Okragly, A. Glasebrook, N. Fox, E. Galbreath, Q. Zhang, H. Y. Song, S. Na, et al. LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function Int. Immunol., July 1, 2003; 15(7): 861 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Creusot, L. L. Thomsen, J. P. Tite, and B. M. Chain Local Cooperation Dominates Over Competition Between CD4+ T Cells of Different Antigen/MHC Specificity J. Immunol., July 1, 2003; 171(1): 240 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mendez-Samperio, H. Ayala, and A. Vazquez NF-{kappa}B Is Involved in Regulation of CD40 Ligand Expression on Mycobacterium bovis Bacillus Calmette-Guerin-Activated Human T Cells Clin. Vaccine Immunol., May 1, 2003; 10(3): 376 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhai, L. Meng, R. W. Busuttil, M. H. Sayegh, and J. W. Kupiec-Weglinski Activation of Alloreactive CD8+ T Cells Operates Via CD4-Dependent and CD4-Independent Mechanisms and Is CD154 Blockade Sensitive J. Immunol., March 15, 2003; 170(6): 3024 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Thebeau and L. A. Morrison Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation J. Virol., February 15, 2003; 77(4): 2426 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Skov, K. Rieneck, L. F. Bovin, K. Skak, S. Tomra, B. K. Michelsen, and N. Odum Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression Blood, February 15, 2003; 101(4): 1430 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Hamilton, A. Genin, R. Q. Cron, and W. F. C. Rigby Delineation of a Novel Pathway That Regulates CD154 (CD40 Ligand) Expression Mol. Cell. Biol., January 15, 2003; 23(2): 510 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D H. Jones, Y-Y Kong, and J M Penninger Role of RANKL and RANK in bone loss and arthritis Ann Rheum Dis, November 1, 2002; 61(90002): ii32 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhai, L. Meng, F. Gao, R. W. Busuttil, and J. W. Kupiec-Weglinski Allograft Rejection by Primed/Memory CD8+ T Cells Is CD154 Blockade Resistant: Therapeutic Implications for Sensitized Transplant Recipients J. Immunol., October 15, 2002; 169(8): 4667 - 4673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. O. Lee, L. Haynes, S. M. Eaton, S. L. Swain, and T. D. Randall The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression: Reciprocal Regulation by Interleukin (IL)-4 and IL-12 J. Exp. Med., September 2, 2002; 196(5): 693 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Roy, C. H. Kim, and E. C. Butcher Cytokine Control of Memory B Cell Homing Machinery J. Immunol., August 15, 2002; 169(4): 1676 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhai, X.-D. Shen, F. Gao, A. J. Coito, B. A. Wasowska, A. Salama, I. Schmitt, R. W. Busuttil, M. H. Sayegh, and J. W. Kupiec-Weglinski The CD154-CD40 T Cell Costimulation Pathway Is Required for Host Sensitization of CD8+ T Cells by Skin Grafts Via Direct Antigen Presentation J. Immunol., August 1, 2002; 169(3): 1270 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tsunetsugu-Yokota, H. Tamura, M. Tachibana, K. Ogata, M. Honda, and T. Takemori Selective expansion of perforin-positive CD8+ T cells by immature dendritic cells infected with live Bacillus Calmette-Guerin mycobacteria J. Leukoc. Biol., July 1, 2002; 72(1): 115 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C G Katsiari, S-N. Liossis, A M Dimopoulos, D V Charalambopoulos, M Mavrikakis, and P P Sfikakis CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition Lupus, June 1, 2002; 11(6): 370 - 378. [Abstract] [PDF]
|
|
|
|
|
|
N. V. Sipsas, P. P. Sfikakis, A. Kontos, and T. Kordossis Levels of Soluble CD40 Ligand (CD154) in Serum Are Increased in Human Immunodeficiency Virus Type 1-Infected Patients and Correlate with CD4+ T-Cell Counts Clin. Vaccine Immunol., May 1, 2002; 9(3): 558 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Buning, K. Kruger, T. Sieber, D. Schoeler, and F. Schriever Increased Expression of CD40 Ligand on Activated T Cells of Patients with Colon Cancer Clin. Cancer Res., April 1, 2002; 8(4): 1147 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ise, M. Totsuka, Y. Sogawa, A. Ametani, S. Hachimura, T. Sato, Y. Kumagai, S. Habu, and S. Kaminogawa Naive CD4+ T Cells Exhibit Distinct Expression Patterns of Cytokines and Cell Surface Molecules on Their Primary Responses to Varying Doses of Antigen J. Immunol., April 1, 2002; 168(7): 3242 - 3250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Atamas, I. G. Luzina, H. Dai, S. G. Wilt, and B. White Synergy Between CD40 Ligation and IL-4 on Fibroblast Proliferation Involves IL-4 Receptor Signaling J. Immunol., February 1, 2002; 168(3): 1139 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. G. O'Gorman, B. DuChateau, M. Paniagua, J. Hunt, N. Bensen, and R. Yogev Abnormal CD40 Ligand (CD154) Expression in Human Immunodeficiency Virus-Infected Children Clin. Vaccine Immunol., November 1, 2001; 8(6): 1104 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Kershaw, C. Hsu, W. Mondesire, L. L. Parker, G. Wang, W. W. Overwijk, R. Lapointe, J. C. Yang, R.-F. Wang, N. P. Restifo, et al. Immunization against Endogenous Retroviral Tumor-associated Antigens Cancer Res., November 1, 2001; 61(21): 7920 - 7924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-O. Vidalain, O. Azocar, H. Yagita, C. Rabourdin-Combe, and C. Servet-Delprat Cytotoxic Activity of Human Dendritic Cells Is Differentially Regulated by Double-Stranded RNA and CD40 Ligand J. Immunol., October 1, 2001; 167(7): 3765 - 3772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rossi, J. Sarkar, and D. Scandella Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A Blood, May 1, 2001; 97(9): 2750 - 2757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Tong, M. H. Papayoti, G. Netto, D. T. Armstrong, G. Ordonez, J. M. Lawson, and M. J. Stone Growth-inhibitory Effects of CD40 Ligand (CD154) and Its Endogenous Expression in Human Breast Cancer Clin. Cancer Res., March 1, 2001; 7(3): 691 - 703. [Abstract] [Full Text]
|
|
|
|
|
|
A. V. Gorbachev, P. S. Heeger, and R. L. Fairchild CD4+ and CD8+ T Cell Priming for Contact Hypersensitivity Occurs Independently of CD40-CD154 Interactions J. Immunol., February 15, 2001; 166(4): 2323 - 2332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Parra, T. Mustelin, M. Dohlsten, and D. Mercola Identification of a CD28 Response Element in the CD40 Ligand Promoter J. Immunol., February 15, 2001; 166(4): 2437 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yi, M. McNerney, and S. K. Datta Regulatory Defects in Cbl and Mitogen-Activated Protein Kinase (Extracellular Signal-Related Kinase) Pathways Cause Persistent Hyperexpression of CD40 Ligand in Human Lupus T Cells J. Immunol., December 1, 2000; 165(11): 6627 - 6634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kikuchi, N. Miyazawa, M. A. S. Moore, and R. G. Crystal Tumor Regression Induced by Intratumor Administration of Adenovirus Vector Expressing CD40 Ligand and Naive Dendritic Cells Cancer Res., November 1, 2000; 60(22): 6391 - 6395. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. M. WOLTMAN, S. DE HAIJ, J. G. BOONSTRA, S. J.P. GOBIN, M. R. DAHA, and C. V. KOOTEN Interleukin-17 and CD40-Ligand Synergistically Enhance Cytokine and Chemokine Production by Renal Epithelial Cells J. Am. Soc. Nephrol., November 1, 2000; 11(11): 2044 - 2055. [Abstract] [Full Text]
|
|
|
|
|
|
B. Barnhart, P. A. Kosinski, Z. Wang, G. S. Ford, M. Kiledjian, and L. R. Covey Identification of a Complex that Binds to the CD154 3' Untranslated Region: Implications for a Role in Message Stability During T Cell Activation J. Immunol., October 15, 2000; 165(8): 4478 - 4486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
