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The Journal of Immunology, Vol 151, Issue 11 6338-6346, Copyright © 1993 by American Association of Immunologists

ARTICLES

Neutrophils roll on E-selectin

MB Lawrence and TA Springer
Center for Blood Research, Harvard Medical School, Boston, MA 02115.

Using flow conditions that simulate those in post capillary venules, we have found that neutrophils attach and roll on a substrate bearing purified E-selectin. E-selectin resembles P-selectin (CD62) with regard to the dependence of attachment efficiency on wall shear stress and selectin density. In contrast, once attached, neutrophils form rolling adhesions on E-selectin that are much stronger than those on P- selectin. Rolling velocities on E-selectin are slower and have less variance than on P-selectin. With increasing shear stress, rolling velocities reach a plateau level that is dependent on E-selectin density, suggesting that the number of receptor-ligand bonds and the bond dissociation rate limit rolling velocity, and that the bonds are not broken by the applied force.


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