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The Journal of Immunology, Vol 151, Issue 11 5993-6001, Copyright © 1993 by American Association of Immunologists

ARTICLES

Avidity for antigen can influence the helper dependence of CD8+ T lymphocytes

WR Heath, L Kjer-Nielsen and MW Hoffmann
Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia.

To examine the influence of avidity on the helper dependence of CD8+ T cells, purified CD8+ T cells from transgenic mice expressing a TCR specific for H-2Kb were tested for their responsiveness to spleen cells expressing different densities of H-2Kb. High avidity interactions resulted in the induction of strong proliferative responses by purified CD8+ T cells. These cells synthesized their own IL-2 and IL-2R. By contrast, low avidity interactions failed to induce proliferation or detectable IL-2 synthesis, although IL-2R were induced and addition of rIL-2 induced a proliferative response. These results are consistent with a model in which TCR avidity for Ag can determine the helper dependence of a CD8+ T cell.


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