The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DiBrino, M.
Right arrow Articles by Biddison, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DiBrino, M.
Right arrow Articles by Biddison, W. E.

The Journal of Immunology, Vol 151, Issue 11 5930-5935, Copyright © 1993 by American Association of Immunologists

ARTICLES

HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs

M DiBrino, T Tsuchida, RV Turner, KC Parker, JE Coligan and WE Biddison
Biological Resources Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892.

The potential value of peptide binding motifs of HLA class I molecules for the prediction of viral epitopes presented to T cells has been analyzed for two common HLA alleles. CTL generated against type A influenza virus recognize peptide epitopes derived from the nucleoprotein (NP) and basic polymerase 1 presented by HLA-A1, and epitopes derived from NP presented by HLA-A3. Distinct peptide binding motifs with characteristic anchor residues were previously identified for each of these class I molecules based on the sequences of endogenous peptides: for HLA-A1, position 3 = Asp or Glu and position 9 = Tyr; for HLA-A3, position 2 = Leu and position 9 = Lys or Tyr. Six peptides containing the HLA-A1 binding motif were identified within the sequences of the NP and basic polymerase 1 proteins, and one peptide containing the HLA-A3 motif was identified in the NP molecule. Three of the six HLA-A1 peptides and the one HLA-A3 NP peptide could bind to HLA- A1 or HLA-A3, respectively, in an in vitro peptide binding assay. Two of the HLA-A1-binding peptides could sensitize target cells for lysis by influenza virus-immune CTL populations restricted by HLA-A1 (NP 44- 52 CTELKLSDY and PB1 591-599 VSDGGPNLY), and the one HLA-A3 NP peptide (NP 265-273 ILRGSVAHK) could sensitize target cells for lysis by HLA-A3- restricted influenza-immune CTL. Each peptide was also shown to be able to induce peptide-specific class I-restricted CTL in vitro, and the CTL generated against two of these peptides could specifically recognize virus-infected targets. Thus, these peptide binding motifs can be used to construct immunogenic synthetic epitopes which are capable of inducing antiviral T cell-mediated immune responses.


This article has been cited by other articles:


Home page
 J. Virol.Home page
E. Assarsson, H.-H. Bui, J. Sidney, Q. Zhang, J. Glenn, C. Oseroff, I. N. Mbawuike, J. Alexander, M. J. Newman, H. Grey, et al.
Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans
J. Virol., December 15, 2008; 82(24): 12241 - 12251.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
E. G. M. Berkhoff, M. M. Geelhoed-Mieras, R. A. M. Fouchier, A. D. M. E. Osterhaus, and G. F. Rimmelzwaan
Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones
J. Gen. Virol., February 1, 2007; 88(2): 530 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
Y. Suzuki
Natural Selection on the Influenza Virus Genome
Mol. Biol. Evol., October 1, 2006; 23(10): 1902 - 1911.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. M. Luiten, E. W.M. Kueter, W. Mooi, M. P.W. Gallee, E. M. Rankin, W. R. Gerritsen, S. M. Clift, W. J. Nooijen, P. Weder, W. F. van de Kasteele, et al.
Immunogenicity, Including Vitiligo, and Feasibility of Vaccination With Autologous GM-CSF-Transduced Tumor Cells in Metastatic Melanoma Patients
J. Clin. Oncol., December 10, 2005; 23(35): 8978 - 8991.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. G. M. Berkhoff, E. de Wit, M. M. Geelhoed-Mieras, A. C. M. Boon, J. Symons, R. A. M. Fouchier, A. D. M. E. Osterhaus, and G. F. Rimmelzwaan
Functional Constraints of Influenza A Virus Epitopes Limit Escape from Cytotoxic T Lymphocytes
J. Virol., September 1, 2005; 79(17): 11239 - 11246.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Zhou, D. Y. Jun, A. M. Thomas, X. Huang, L.-Q. Huang, J. Mautner, W. Mo, P. F. Robbins, D. M. Pardoll, and E. M. Jaffee
Diverse CD8+ T-Cell Responses to Renal Cell Carcinoma Antigens in Patients Treated with an Autologous Granulocyte-Macrophage Colony-Stimulating Factor Gene-Transduced Renal Tumor Cell Vaccine
Cancer Res., February 1, 2005; 65(3): 1079 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. L. Smith, A. Tristram, K. M. Gallagher, A. N. Fiander, and S. Man
Epitope specificity and longevity of a vaccine-induced human T cell response against HPV18
Int. Immunol., February 1, 2005; 17(2): 167 - 176.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Li, J. S. Heuser, S. D. Kosanke, M. Hemric, and M. W. Cunningham
Cryptic Epitope Identified in Rat and Human Cardiac Myosin S2 Region Induces Myocarditis in the Lewis Rat
J. Immunol., March 1, 2004; 172(5): 3225 - 3234.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Karanikas, C. Lurquin, D. Colau, N. van Baren, C. De Smet, B. Lethe, T. Connerotte, V. Corbiere, M.-A. Demoitie, D. Lienard, et al.
Monoclonal Anti-MAGE-3 CTL Responses in Melanoma Patients Displaying Tumor Regression after Vaccination with a Recombinant Canarypox Virus
J. Immunol., November 1, 2003; 171(9): 4898 - 4904.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. J. Gagnon, Z. Wang, R. Turner, M. Damirjian, and W. E. Biddison
MHC Recognition by Hapten-Specific HLA-A2-Restricted CD8+ CTL
J. Immunol., September 1, 2003; 171(5): 2233 - 2241.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
R. Forsberg and F. B. Christiansen
A Codon-Based Model of Host-Specific Selection in Parasites, with an Application to the Influenza A Virus
Mol. Biol. Evol., August 1, 2003; 20(8): 1252 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
P.-S. Rohrlich, S. Cardinaud, H. Firat, M. Lamari, P. Briand, N. Escriou, and F. A. Lemonnier
HLA-B*0702 transgenic, H-2KbDb double-knockout mice: phenotypical and functional characterization in response to influenza virus
Int. Immunol., June 1, 2003; 15(6): 765 - 772.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H. Lewicki, A. Tishon, D. Homann, H. Mazarguil, F. Laval, V. C. Asensio, I. L. Campbell, S. DeArmond, B. Coon, C. Teng, et al.
T Cells Infiltrate the Brain in Murine and Human Transmissible Spongiform Encephalopathies
J. Virol., March 15, 2003; 77(6): 3799 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. R. Reynolds, A. Zeleniuch-Jacquotte, R. L. Shapiro, D. F. Roses, M. N. Harris, D. Johnston, and J.-C. Bystryn
Vaccine-induced CD8+ T-cell Responses to MAGE-3 Correlate with Clinical Outcome in Patients with Melanoma
Clin. Cancer Res., February 1, 2003; 9(2): 657 - 662.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. T. Brice, N. L. Graber, D. J. Carucci, and D. L. Doolan
Optimal induction of antigen-specific CD8+ T cell responses requires bystander cell participation
J. Leukoc. Biol., December 1, 2002; 72(6): 1164 - 1171.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. C. M. Boon, G. de Mutsert, Y. M. F. Graus, R. A. M. Fouchier, K. Sintnicolaas, A. D. M. E. Osterhaus, and G. F. Rimmelzwaan
The Magnitude and Specificity of Influenza A Virus-Specific Cytotoxic T-Lymphocyte Responses in Humans Is Related to HLA-A and -B Phenotype
J. Virol., January 15, 2002; 76(2): 582 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. M. Lawson, S. Man, S. Williams, A. C. M. Boon, M. Zambon, and L. K. Borysiewicz
Influenza A antigen exposure selects dominant V{beta}17+ TCR in human CD8+ cytotoxic T cell responses
Int. Immunol., November 1, 2001; 13(11): 1373 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. H. Vonderheide, K. S. Anderson, W. C. Hahn, M. O. Butler, J. L. Schultze, and L. M. Nadler
Characterization of HLA-A3-restricted Cytotoxic T Lymphocytes Reactive against the Widely Expressed Tumor Antigen Telomerase
Clin. Cancer Res., November 1, 2001; 7(11): 3343 - 3348.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. S. Gricks, E. Rawlings, L. Foroni, J. A. Madrigal, and P. L. Amlot
Somatically Mutated Regions of Immunoglobulin on Human B-Cell Lymphomas Code for Peptides That Bind to Autologous Major Histocompatibility Complex Class I, Providing a Potential Target for Cytotoxic T Cells
Cancer Res., July 1, 2001; 61(13): 5145 - 5152.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Kumar, S. Kumar, T. P. Le, S. Southwood, J. Sidney, J. Cohen, A. Sette, and S. L. Hoffman
HLA-A*01-Restricted Cytotoxic T-Lymphocyte Epitope from the Plasmodium falciparum Circumsporozoite Protein
Infect. Immun., April 1, 2001; 69(4): 2766 - 2771.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. T. M. Voeten, T. M. Bestebroer, N. J. Nieuwkoop, R. A. M. Fouchier, A. D. M. E. Osterhaus, and G. F. Rimmelzwaan
Antigenic Drift in the Influenza A Virus (H3N2) Nucleoprotein and Escape from Recognition by Cytotoxic T Lymphocytes
J. Virol., August 1, 2000; 74(15): 6800 - 6807.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
H. Asahi, A. Osman, R. M. Cook, P. T. LoVerde, and M. J. Stadecker
Schistosoma mansoni Phosphoenolpyruvate Carboxykinase, a Novel Egg Antigen: Immunological Properties of the Recombinant Protein and Identification of a T-Cell Epitope
Infect. Immun., June 1, 2000; 68(6): 3385 - 3393.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. L. Dzuris, J. Sidney, E. Appella, R. W. Chesnut, D. I. Watkins, and A. Sette
Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques
J. Immunol., January 1, 2000; 164(1): 283 - 291.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Jameson, J. Cruz, and F. A. Ennis
Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses
J. Virol., November 1, 1998; 72(11): 8682 - 8689.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Shields, R. Kubota, W. Hodgson, S. Jacobson, W. E. Biddison, and R. K. Ribaudo
The Effect of Human beta 2-Microglobulin on Major Histocompatibility Complex I Peptide Loading and the Engineering of a High Affinity Variant. IMPLICATIONS FOR PEPTIDE-BASED VACCINES
J. Biol. Chem., October 23, 1998; 273(43): 28010 - 28018.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. J. Kittlesen, L. W. Thompson, P. H. Gulden, J. C. A. Skipper, T. A. Colella, J. A. Shabanowitz, D. F. Hunt, V. H. Engelhard, and C. L. Slingluff Jr.
Human Melanoma Patients Recognize an HLA-A1-Restricted CTL Epitope from Tyrosinase Containing Two Cysteine Residues: Implications for Tumor Vaccine Development
J. Immunol., March 1, 1998; 160(5): 2099 - 2106.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1993 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1993 by The American Association of Immunologists, Inc. All rights reserved.