The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Denis, M.
Right arrow Articles by Ghadirian, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Denis, M.
Right arrow Articles by Ghadirian, E.

The Journal of Immunology, Vol 151, Issue 10 5425-5430, Copyright © 1993 by American Association of Immunologists

ARTICLES

IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections

M Denis and E Ghadirian
Pulmonary Research Unit, Faculty of Medicine, University of Sherbrooke, Canada.

In this contribution, we examined the involvement of the cytokine IL-10 in the progression of experimental murine Mycobacterium avium infections in susceptible BALB/c mice. Addition of anti-IL-10 antibodies in the supernatants of peritoneal macrophages infected with virulent M. avium resulted in a significantly enhanced mycobacteriostatic activity of macrophages. In BALB/c mice infected with the B101 or B102 virulent M. avium strains, examination of the cytokine release profile in splenocytes from infected mice showed that infection was associated with an initial copious release of both IFN- gamma and IL-10. IL-10 production increased as the infection progressed, whereas IFN-gamma levels diminished. Infected mice were given repeated infusions of a rat mAb against mouse IL-10 or rat IgM. Examination of IgM serum levels in anti-IL-10-treated mice (infected or not) showed that depletion of endogenous IL-10 resulted in much decreased IgM levels. Results showed that infusions of large dosages of the monoclonal anti-IL-10 resulted in a very significantly diminished bacterial growth in the spleens. These findings indicate that IL-10 may have a negative impact on resistance to M. avium infections, due, at least in part, to decreased macrophage activity.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Roque, C. Nobrega, R. Appelberg, and M. Correia-Neves
IL-10 Underlies Distinct Susceptibility of BALB/c and C57BL/6 Mice to Mycobacterium avium Infection and Influences Efficacy of Antibiotic Therapy
J. Immunol., June 15, 2007; 178(12): 8028 - 8035.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. Foulds, M. J. Rotte, and R. A. Seder
IL-10 Is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection
J. Immunol., August 15, 2006; 177(4): 2565 - 2574.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K.-i. Uchiya, E. A. Groisman, and T. Nikai
Involvement of Salmonella Pathogenicity Island 2 in the Up-Regulation of Interleukin-10 Expression in Macrophages: Role of Protein Kinase A Signal Pathway
Infect. Immun., April 1, 2004; 72(4): 1964 - 1973.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Matsunaga, H. Yamaguchi, T. W. Klein, H. Friedman, and Y. Yamamoto
Legionella pneumophila Suppresses Macrophage Interleukin-12 Production by Activating the p42/44 Mitogen-Activated Protein Kinase Cascade
Infect. Immun., November 1, 2003; 71(11): 6672 - 6675.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. G. Feng, M. C. Kullberg, D. Jankovic, A. W. Cheever, P. Caspar, R. L. Coffman, and A. Sher
Transgenic Mice Expressing Human Interleukin-10 in the Antigen-Presenting Cell Compartment Show Increased Susceptibility to Infection with Mycobacterium avium Associated with Decreased Macrophage Effector Function and Apoptosis
Infect. Immun., December 1, 2002; 70(12): 6672 - 6679.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Blumenthal, S. Ehlers, M. Ernst, H.-D. Flad, and N. Reiling
Control of Mycobacterial Replication in Human Macrophages: Roles of Extracellular Signal-Regulated Kinases 1 and 2 and p38 Mitogen-Activated Protein Kinase Pathways
Infect. Immun., September 1, 2002; 70(9): 4961 - 4967.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
K. Matsunaga, T. W. Klein, H. Friedman, and Y. Yamamoto
Epigallocatechin Gallate, a Potential Immunomodulatory Agent of Tea Components, Diminishes Cigarette Smoke Condensate-Induced Suppression of Anti-Legionella pneumophila Activity and Cytokine Responses of Alveolar Macrophages
Clin. Vaccine Immunol., July 1, 2002; 9(4): 864 - 871.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
K. J. Erb, C. Trujillo, M. Fugate, and H. Moll
Infection with the Helminth Nippostrongylus brasiliensis Does Not Interfere with Efficient Elimination of Mycobacterium bovis BCG from the Lungs of Mice
Clin. Vaccine Immunol., May 1, 2002; 9(3): 727 - 730.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-C. Wang and J. R. Klein
Multiple Levels of Activation of Murine CD8+ Intraepithelial Lymphocytes Defined by OX40 (CD134) Expression: Effects on Cell-Mediated Cytotoxicity, IFN-{gamma}, and IL-10 Regulation
J. Immunol., December 15, 2001; 167(12): 6717 - 6723.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y. Shibata, I. Honda, J. P. Justice, M. R. Van Scott, R. M. Nakamura, and Q. N. Myrvik
Th1 Adjuvant N-Acetyl-D-Glucosamine Polymer Up-Regulates Th1 Immunity but Down-Regulates Th2 Immunity against a Mycobacterial Protein (MPB-59) in Interleukin-10-Knockout and Wild-Type Mice
Infect. Immun., October 1, 2001; 69(10): 6123 - 6130.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
Y. M. KOHANAWA, Y. SATO, and T. MINAGAWA
Role of T cells in granuloma formation induced by Rhodococcus aurantiacus is independent of their interferon-gamma production
J. Med. Microbiol., August 1, 2001; 50(8): 688 - 694.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. A. Silva, T. F. Pais, and R. Appelberg
Blocking the Receptor for IL-10 Improves Antimycobacterial Chemotherapy and Vaccination
J. Immunol., August 1, 2001; 167(3): 1535 - 1541.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
Y. Nishikawa, K. Tragoolpua, N. Inoue, L. Makala, H. Nagasawa, H. Otsuka, and T. Mikami
In the Absence of Endogenous Gamma Interferon, Mice Acutely Infected with Neospora caninum Succumb to a Lethal Immune Response Characterized by Inactivation of Peritoneal Macrophages
Clin. Vaccine Immunol., July 1, 2001; 8(4): 811 - 817.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Matsunaga, T. W. Klein, H. Friedman, and Y. Yamamoto
Legionella pneumophila Replication in Macrophages Inhibited by Selective Immunomodulatory Effects on Cytokine Formation by Epigallocatechin Gallate, a Major Form of Tea Catechins
Infect. Immun., June 1, 2001; 69(6): 3947 - 3953.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Ghigo, C. Capo, D. Raoult, and J.-L. Mege
Interleukin-10 Stimulates Coxiella burnetii Replication in Human Monocytes through Tumor Necrosis Factor Down-Modulation: Role in Microbicidal Defect of Q Fever
Infect. Immun., April 1, 2001; 69(4): 2345 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Bhattacharyya, S. Ghosh, P. L. Jhonson, S. K. Bhattacharya, and S. Majumdar
Immunomodulatory Role of Interleukin-10 in Visceral Leishmaniasis: Defective Activation of Protein Kinase C-Mediated Signal Transduction Events
Infect. Immun., March 1, 2001; 69(3): 1499 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. N. Samsom, A. Annema, M. F. Geertsma, J. A. M. Langermans, P. H. P. Groeneveld, E. de Heer, and R. van Furth
Interleukin-10 Has Different Effects on Proliferation of Listeria monocytogenes in Livers and Spleens of Mice
Infect. Immun., August 1, 2000; 68(8): 4666 - 4672.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Holscher, M. Mohrs, W. J. Dai, G. Kohler, B. Ryffel, G. A. Schaub, H. Mossmann, and F. Brombacher
Tumor Necrosis Factor Alpha-Mediated Toxic Shock in Trypanosoma cruzi-Infected Interleukin 10-Deficient Mice
Infect. Immun., July 1, 2000; 68(7): 4075 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. J. Murray and R. A. Young
Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice
Infect. Immun., June 1, 1999; 67(6): 3087 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
T. Shimizu, H. Tomioka, K. Sato, C. Sano, T. Akaki, S. Dekio, Y. Yamada, T. Kamei, H. Shibata, and N. Higashi
Effects of the Chinese Traditional Medicine Mao-Bushi-Saishin-To on Therapeutic Efficacy of a New Benzoxazinorifamycin, KRM-1648, against Mycobacterium avium Infection in Mice
Antimicrob. Agents Chemother., March 1, 1999; 43(3): 514 - 519.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
L. V. Rizzo, R. A. Morawetz, N. E. Miller-Rivero, R. Choi, B. Wiggert, C.-C. Chan, H. C. Morse III, R. B. Nussenblatt, and R. R. Caspi
IL-4 and IL-10 Are Both Required for the Induction of Oral Tolerance
J. Immunol., March 1, 1999; 162(5): 2613 - 2622.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
T. Matsumoto, K. Tateda, S. Miyazaki, N. Furuya, A. Ohno, Y. Ishii, Y. Hirakata, and K. Yamaguchi
Effect of Interleukin-10 on Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice
Antimicrob. Agents Chemother., November 1, 1998; 42(11): 2853 - 2857.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1993 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1993 by The American Association of Immunologists, Inc. All rights reserved.