The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schmidt-Wolf, I. G.
Right arrow Articles by Strober, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmidt-Wolf, I. G.
Right arrow Articles by Strober, S.

The Journal of Immunology, Vol 151, Issue 10 5348-5353, Copyright © 1993 by American Association of Immunologists

ARTICLES

Homogeneous antigen receptor beta-chain genes in cloned CD4- CD8- alpha beta T suppressor cells

IG Schmidt-Wolf, O Liang, S Dejbakhsh-Jones, H Wang, L Cheng, B Holm, R Bell and S Strober
Department of Medicine, Stanford University School of Medicine, CA 94305.

The rearrangements of beta-chain genes of the T cell Ag receptor were examined in 12 CD4- CD8- alpha beta + T cell lines derived from the spleen or thymus of neonatal or adult BALB/c mice. Eleven of the lines were cloned and established from six independent cloning procedures from different mice. Five cloned lines used V beta 9, four cloned lines used V beta 15, and two cloned lines used V beta 7. Nucleotide sequencing of the beta-chain genes showed that clones that used a given V beta were identically rearranged even when they were derived from independent cloning procedures. In the case of V beta 7 and V beta 15 all nucleotides in the V-D-J joining region were in the germ line configuration without N region additions. Rearrangements of the V beta 7, V beta 9, and V beta 15 genes were functional. Each V beta 15 clone also had a homogeneous rearrangement of the V beta 13 gene, which was nonfunctional. The predicted amino acid sequence of the joining regions of the V beta 7, V beta 9, and V beta 15 rearrangements showed homology in four of seven amino acids in the peptide contact region.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Dejbakhsh-Jones, M. E. Garcia-Ojeda, D. Chatterjea-Matthes, D. Zeng, and S. Strober
Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway
PNAS, May 30, 2001; (2001) 131559798.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
F. Tilloy, E. Treiner, S.-H. Park, C. Garcia, F. Lemonnier, H. de la Salle, A. Bendelac, M. Bonneville, and O. Lantz
An Invariant T Cell Receptor alpha  Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib-restricted alpha /beta T Cell Subpopulation in Mammals
J. Exp. Med., June 21, 1999; 189(12): 1907 - 1921.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Amano, N. Baumgarth, M. D. Dick, L. Brossay, M. Kronenberg, L. A. Herzenberg, and S. Strober
CD1 Expression Defines Subsets of Follicular and Marginal Zone B Cells in the Spleen: {beta}2-Microglobulin-Dependent and Independent Forms
J. Immunol., August 15, 1998; 161(4): 1710 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Dejbakhsh-Jones, M. E. Garcia-Ojeda, D. Chatterjea-Matthes, D. Zeng, and S. Strober
Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway
PNAS, June 19, 2001; 98(13): 7455 - 7460.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1993 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1993 by The American Association of Immunologists, Inc. All rights reserved.