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The Journal of Immunology, Vol 150, Issue 4 1509-1516, Copyright © 1993 by American Association of Immunologists
ARTICLES |
HM Lander, P Sehajpal, DM Levine and A Novogrodsky
Rogosin Institute, Cornell University Medical College, New York, NY 10021.
Recent work in this laboratory has identified immune-stimulatory properties of the oxidant hemin. In this study, we examined whether the nitrogen-based oxidant nitric oxide (NO) had inductive effects on human lymphocytes. We found that the NO-generating compounds sodium nitroprusside and S-nitroso-N-acetylpenicillamine rapidly enhanced the rate of glucose transport in resting human PBMC. In addition, NF-kappa B binding activity was induced by these agents as was the secretion of TNF-alpha. The data suggest that a cGMP-independent mechanism is involved as the cell permeant cGMP analogue, 8-Br-cGMP, had no effect in eliciting these inductive events. Activation of lymphocytes by these NO-generating compounds may be mediated through the protein tyrosine phosphorylation signal transduction pathway. We found that membrane- associated protein tyrosine phosphatase activity was enhanced in PBMC treated with sodium nitroprusside or S-nitroso-N-acetylpenicillamine and that the src family protein tyrosine kinase p56lck was activated in these cells. Inasmuch as p56lck activity is negatively controlled by tyrosine phosphorylation, its activation may be related to the enhancement of protein tyrosine phosphatase activity. 8-Br-cGMP had no effect on these enzymes. Taken together, these data suggest that NO may have immune-stimulatory properties and may signal through a hitherto undescribed cGMP-independent pathway.
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H. M. Lander, J. M. Tauras, J. S. Ogiste, O. Hori, R. A. Moss, and A. M. Schmidt Activation of the Receptor for Advanced Glycation End Products Triggers a p21ras-dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress J. Biol. Chem., July 11, 1997; 272(28): 17810 - 17814. [Abstract] [Full Text] [PDF]
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 H. Adler, J. L. Beland, N. C. Del-Pan, L. Kobzik, J. P. Brewer, T. R. Martin, and I. J. Rimm Suppression of Herpes Simplex Virus Type 1 (HSV-1)-induced Pneumonia in Mice by Inhibition of Inducible Nitric Oxide Synthase (iNOS, NOS2) J. Exp. Med., May 5, 1997; 185(9): 1533 - 1540. [Abstract] [Full Text] [PDF]
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J. A. Lopez-Guerrero, B. Rayet, M. Tuynder, J. Rommelaere, and C. Dinsart Constitutive Activation of U937 Promonocytic Cell Clones Selected for Their Resistance to Parvovirus H-1 Infection Blood, March 1, 1997; 89(5): 1642 - 1653. [Abstract] [Full Text] [PDF]
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S. Wang, L. Yan, R. A. Wesley, and R. L. Danner Nitric Oxide Increases Tumor Necrosis Factor Production in Differentiated U937 Cells by Decreasing Cyclic AMP J. Biol. Chem., February 28, 1997; 272(9): 5959 - 5965. [Abstract] [Full Text] [PDF]
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HarryM. Lander, DavidP. Hajjar, BarbaraL. Hempstead, UroojA. Mirza, BrianT. Chait, S. Campbell, and LawrenceA. Quilliam A Molecular Redox Switch on p21ras. STRUCTURAL BASIS FOR THE NITRIC OXIDE-p21ras INTERACTION J. Biol. Chem., February 14, 1997; 272(7): 4323 - 4326. [Abstract] [Full Text] [PDF]
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H. M. Lander, A. T. Jacovina, R. J. Davis, and J. M. Tauras Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species J. Biol. Chem., August 16, 1996; 271(33): 19705 - 19709. [Abstract] [Full Text] [PDF]
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Céc. Bouton, M. Raveau, and J.-C. Drapier Modulation of Iron Regulatory Protein Functions J. Biol. Chem., January 26, 1996; 271(4): 2300 - 2306. [Abstract] [Full Text] [PDF]
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M. Boese, P. I. Mordvintcev, A. F. Vanin, R. Busse, and A. Mülsch S-Nitrosation of Serum Albumin by Dinitrosyl-Iron Complex J. Biol. Chem., December 8, 1995; 270(49): 29244 - 29249. [Abstract] [Full Text] [PDF]
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H. M. Lander, J. S. Ogiste, K. K. Teng, and A. Novogrodsky p21[IMAGE] as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress J. Biol. Chem., September 8, 1995; 270(36): 21195 - 21198. [Abstract] [Full Text] [PDF]
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U. A. Mirza, B. T. Chait, and H. M. Lander Monitoring Reactions of Nitric Oxide with Peptides and Proteins by Electrospray Ionization-Mass Spectrometry J. Biol. Chem., July 21, 1995; 270(29): 17185 - 17188. [Abstract] [Full Text] [PDF]
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R. W. Gross, A. E. Rudolph, J. Wang, C. D. Sommers, and M. J. Wolf Nitric Oxide Activates the Glucose-dependent Mobilization of Arachidonic Acid in a Macrophage-like Cell Line (RAW 264.7) That Is Largely Mediated by Calcium-independent Phospholipase A[IMAGE] J. Biol. Chem., June 23, 1995; 270(25): 14855 - 14858. [Abstract] [Full Text] [PDF]
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H.-B. Peng, P. Libby, and J. K. Liao Induction and Stabilization of I[IMAGE]B[IMAGE] by Nitric Oxide Mediates Inhibition of NF-[IMAGE]B J. Biol. Chem., June 9, 1995; 270(23): 14214 - 14219. [Abstract] [Full Text] [PDF]
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H. M. Lander, J. S. Ogiste, R. Levi, and A. Novogrodsky Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21[IMAGE] J. Biol. Chem., March 31, 1995; 270(13): 7017 - 7020. [Abstract] [Full Text] [PDF]
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 G Karupiah, Q. Xie, R. Buller, C Nathan, C Duarte, and J. MacMicking Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase Science, September 10, 1993; 261(5127): 1445 - 1448. [Abstract] [PDF]
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