| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 150, Issue 4 1205-1211, Copyright © 1993 by American Association of Immunologists
ARTICLES |
T Krakauer and JJ Oppenheim
Medical Division, USAMRIID, Fort Detrick, Frederick, MD 21702-5011.
Stimulation of human blood monocytes (adherent mononuclear cells) and the monocytic cell line, THP-1, by IL-1 or TNF-alpha leads to the up- regulation of IFN-gamma receptors. Scatchard analysis using 125I-IFN- gamma revealed a twofold increase in the number of IFN-gamma receptors on THP-1 cells without an alteration in the affinity of the receptor. The potential functional significance of this induction of IFN-gamma receptors on monocytes and THP-1 cells was investigated by examining the effect of IFN-gamma on MHC class II Ag expression by these cells. Both IL-1 and TNF-alpha enhanced the IFN-gamma-induced HLA-DR expression (> twofold) and this effect was inhibited by antibody to IFN- gamma. In the case of human monocytes, IL-1 or TNF-alpha, each by themselves also increased HLA-DR expression, which was also abrogated by antibody to IFN-gamma. The data suggest that the immunopotentiating effects of IL-1 and TNF-alpha are mediated in part by enhancing IFN- gamma receptor expression on monocytes and macrophages. This presumably would increase the capacity of IFN-gamma to activate macrophages, enabling them to express HLA-DR and present Ag more effectively.
This article has been cited by other articles:
|
|
 |
|
  O. Tliba and Y. Amrani Airway Smooth Muscle Cell as an Inflammatory Cell: Lessons Learned from Interferon Signaling Pathways Proceedings of the ATS, January 1, 2008; 5(1): 106 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Crescioli, L Cosmi, E Borgogni, V Santarlasci, S Gelmini, M Sottili, E Sarchielli, B Mazzinghi, M Francalanci, A Pezzatini, et al. Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes J. Endocrinol., October 1, 2007; 195(1): 145 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Y. Liu, M. E. Bates, N. N. Jarjour, W. W. Busse, P. J. Bertics, and E. A. B. Kelly Generation of Th1 and Th2 Chemokines by Human Eosinophils: Evidence for a Critical Role of TNF-{alpha} J. Immunol., October 1, 2007; 179(7): 4840 - 4848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Singhal, A. Jaiswal, V. K. Arora, and H. K. Prasad Modulation of Gamma Interferon Receptor 1 by Mycobacterium tuberculosis: a Potential Immune Response Evasive Mechanism Infect. Immun., May 1, 2007; 75(5): 2500 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Shirey, J.-Y. Jung, and J. M. Carlin Up-Regulation of Gamma Interferon Receptor Expression Due to Chlamydia-Toll-Like Receptor Interaction Does Not Enhance Signal Transducer and Activator of Transcription 1 Signaling Infect. Immun., December 1, 2006; 74(12): 6877 - 6884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Shirey and J. M. Carlin Chlamydiae Modulate Gamma Interferon, Interleukin-1{beta}, and Tumor Necrosis Factor Alpha Receptor Expression in HeLa Cells Infect. Immun., April 1, 2006; 74(4): 2482 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Barillari and B. Ensoli Angiogenic Effects of Extracellular Human Immunodeficiency Virus Type 1 Tat Protein and Its Role in the Pathogenesis of AIDS-Associated Kaposi's Sarcoma Clin. Microbiol. Rev., April 1, 2002; 15(2): 310 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Barillari, C. Sgadari, C. Palladino, R. Gendelman, A. Caputo, C. B. Morris, B. C. Nair, P. Markham, A. Nel, M. Sturzl, et al. Inflammatory Cytokines Synergize with the HIV-1 Tat Protein to Promote Angiogenesis and Kaposi's Sarcoma Via Induction of Basic Fibroblast Growth Factor and the {alpha}v{beta}3 Integrin J. Immunol., August 15, 1999; 163(4): 1929 - 1935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hussain, B. S. Zwilling, and W. P. Lafuse Mycobacterium avium Infection of Mouse Macrophages Inhibits IFN-{gamma} Janus Kinase-STAT Signaling and Gene Induction by Down-Regulation of the IFN-{gamma} Receptor J. Immunol., August 15, 1999; 163(4): 2041 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Han, Z-H. L. Zhou, and R. M. Ransohoff TNF-{alpha} Suppresses IFN-{gamma}-Induced MHC Class II Expression in HT1080 Cells by Destabilizing Class II trans-Activator mRNA J. Immunol., August 1, 1999; 163(3): 1435 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Cheshire, B. R. G. Williams, and A. S. Baldwin Jr. Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-kappa B by Tumor Necrosis Factor-alpha and gamma -Interferon in Preneuronal Cells J. Biol. Chem., February 19, 1999; 274(8): 4801 - 4806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fiorelli, G. Barillari, E. Toschi, C. Sgadari, P. Monini, M. Sturzl, and B. Ensoli IFN-{gamma} Induces Endothelial Cells to Proliferate and to Invade the Extracellular Matrix in Response to the HIV-1 Tat Protein: Implications for AIDS-Kaposi's Sarcoma Pathogenesis J. Immunol., January 15, 1999; 162(2): 1165 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Condino-Neto, C. Whitney, and P. E. Newburger Dexamethasone But Not Indomethacin Inhibits Human Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity by Down-Regulating Expression of Genes Encoding Oxidase Components J. Immunol., November 1, 1998; 161(9): 4960 - 4967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-P. Erwig, D. C. Kluth, G. M. Walsh, and A. J. Rees Initial Cytokine Exposure Determines Function of Macrophages and Renders Them Unresponsive to Other Cytokines J. Immunol., August 15, 1998; 161(4): 1983 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Haley, K. Patidar, F. Zhang, R. L. Emanuel, and M. E. Sunday Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L311 - L321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hanano, K. Reifenberg, and S. H. E. Kaufmann Activated Pulmonary Macrophages Are Insufficient for Resistance against Pneumocystis carinii Infect. Immun., January 1, 1998; 66(1): 305 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. BLAINE, R. N. ROSIER, J. E. PUZAS, R. J. LOONEY, P. R. REYNOLDS, S. D. REYNOLDS, and R. J. O'KEEFE Increased Levels of Tumor Necrosis Factor-{{alpha}} and Interleukin-6 Protein and Messenger RNA in Human Peripheral Blood Monocytes due to Titanium Particles J. Bone Joint Surg. Am., August 1, 1996; 78(8): 1181 - 92. [Abstract] [Full Text]
|
|
|
|
|
|
D. G. HICKS, A. R. JUDKINS, J. Z. SICKEL, R. N. ROSIER, J. E. PUZAS, and R. J. O'KEEFE Granular Histiocytosis of Pelvic Lymph Nodes following Total Hip Arthroplasty. The Presence of Wear Debris, Cytokine Production, and Immunologically Activated Macrophages J. Bone Joint Surg. Am., April 1, 1996; 78(4): 482 - 96. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
