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The Journal of Immunology, Vol 150, Issue 12 5436-5444, Copyright © 1993 by American Association of Immunologists

ARTICLES

Structural comparison and chromosomal localization of the human and mouse IL-13 genes

AN McKenzie, X Li, DA Largaespada, A Sato, A Kaneda, SM Zurawski, EL Doyle, A Milatovich, U Francke and NG Copeland
Department of Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304.

The genomic structure of the recently described cytokine IL-13 has been determined for both human and mouse genes. The nucleotide sequence of a 4.6-kb DNA segment of the human gene is described. The human IL-13 gene (IL13) occurs as a single copy in the haploid genome and maps to human chromosome 5. A 4.3-kb DNA fragment of the mouse IL-13 gene (IL13) has been sequenced and found to occur as a single copy, mapping to mouse chromosome 11. Intrachromosomal mapping studies revealed that both genes contain four exons and three introns and show a high degree of sequence identity throughout their length. Potential recognition sequences for transcription factors that are present in the 5'-flanking region and are conserved between both genes include IFN-responsive elements, binding sites for AP-1, AP-2 and AP-3, and NF-IL 6 site, and a TATA-like sequence. Both genes map to chromosomal locations adjacent to genes encoding other cytokines, including IL-3, GM-CSF, IL-5, and IL- 4, suggesting that IL-13 is another member of this cytokine gene family that may have arisen by gene duplication.


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