| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 150, Issue 10 4494-4503, Copyright © 1993 by American Association of Immunologists
ARTICLES |
JR Gamble, Y Khew-Goodall and MA Vadas
Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia.
Transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is elaborated in the active form upon co-culture of endothelial cells and pericytes or smooth muscle cells, has been shown to decrease the adhesiveness of endothelial cells for neutrophils, lymphocytes, and tumor cells. The mechanism whereby TGF-beta inhibits the adhesiveness of human endothelial cells was investigated. TGF-beta inhibited the basal E-selectin (formerly ELAM-1) expression by 55 +/- 7% and TNF- stimulated expression by 57 +/- 4%. Similar decreases of IL-1- stimulated expression were also seen. Peak inhibition was seen at TGF- beta doses between 0.2 and 2 ng/ml. Both TGF-beta 1 and -beta 2 were functional. The effectiveness of TGF-beta in inhibiting E-selectin expression was dependent on cell density and incubation time. TGF-beta also inhibited E-selectin mRNA levels in endothelial cells. TGF-beta had no effect on the expression of VCAM-1 and ICAM-1, but was additive with IL-4 in inhibiting the expression of E-selectin. The expression of E-selectin has been shown to mediate several aspects of the inflammatory response involving neutrophils and memory T lymphocytes. Perivascular TGF-beta appears to act as an inhibitor of the expression of the endothelium-specific selectin, E-selectin, and therefore of inflammatory responses involving neutrophils and (a subset of) lymphocytes.
This article has been cited by other articles:
|
|
 |
|
  C.-L. Chen, I-H. Liu, S. J. Fliesler, X. Han, S. S. Huang, and J. S. Huang Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis J. Cell Sci., October 15, 2007; 120(20): 3509 - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Reynolds, W. Xia, M. D. Holmes, S. J. Hodge, S. Danilov, D. T. Curiel, N. W. Morrell, and P. N. Reynolds Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1182 - L1192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Mehta and H. Attramadal The TGF{beta} superfamily in cardiovascular biology Cardiovasc Res, May 1, 2007; 74(2): 181 - 183. [Full Text] [PDF]
|
|
|
|
|
|
D. J. Grainger TGF-{beta} and atherosclerosis in man Cardiovasc Res, May 1, 2007; 74(2): 213 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Tull, S. I. Anderson, S. C. Hughan, S. P. Watson, G. B. Nash, and G. E. Rainger Cellular Pathology of Atherosclerosis: Smooth Muscle Cells Promote Adhesion of Platelets to Cocultured Endothelial Cells Circ. Res., January 6, 2006; 98(1): 98 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wadham, N. Albanese, J. Roberts, L. Wang, C. J. Bagley, J. R. Gamble, K.-A. Rye, P. J. Barter, M. A. Vadas, and P. Xia High-Density Lipoproteins Neutralize C-Reactive Protein Proinflammatory Activity Circulation, May 4, 2004; 109(17): 2116 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Grainger Transforming Growth Factor {beta} and Atherosclerosis: So Far, So Good for the Protective Cytokine Hypothesis Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 399 - 404. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. N. Stein, J. R. Gamble, S. M. Pitson, M. A. Vadas, and Y. Khew-Goodall Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation J. Immunol., December 1, 2003; 171(11): 6097 - 6104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Vallely, P. G. Bannon, C. F. Hughes, and L. Kritharides Endothelial expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 is suppressed by postbypass plasma containing increased soluble intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 J. Thorac. Cardiovasc. Surg., October 1, 2002; 124(4): 758 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Carlos Leukocyte recruitment at sites of tumor: dissonant orchestration J. Leukoc. Biol., August 1, 2001; 70(2): 171 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Harari, D. Marshall, J. F. McHale, S. Ahmed, and D. O. Haskard Limited endothelial E- and P-selectin expression in MRL/lpr lupus-prone mice Rheumatology, August 1, 2001; 40(8): 889 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Rainger and G. B. Nash Cellular Pathology of Atherosclerosis : Smooth Muscle Cells Prime Cocultured Endothelial Cells for Enhanced Leukocyte Adhesion Circ. Res., March 30, 2001; 88(6): 615 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Harashima, T. Horiuchi, N. Hatta, C. Morita, M. Higuchi, T. Sawabe, H. Tsukamoto, T. Tahira, K. Hayashi, S. Fujita, et al. Outside-to-Inside Signal Through the Membrane TNF-{{alpha}} Induces E-Selectin (CD62E) Expression on Activated Human CD4+ T Cells J. Immunol., January 1, 2001; 166(1): 130 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Faber-Elmann, V. Grabovsky, M. Dayan, M. Sela, R. Alon, and E. Mozes Cytokine profile and T cell adhesiveness to endothelial selectins: in vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand Int. Immunol., December 1, 2000; 12(12): 1651 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. DiChiara, J. M. Kiely, M. A. Gimbrone , Jr., M.-E. Lee, M. A. Perrella, and J. N. Topper Inhibition of E-Selectin Gene Expression by Transforming Growth Factor {beta} in Endothelial Cells Involves Coactivator Integration of Smad and Nuclear Factor {kappa}B-mediated Signals J. Exp. Med., September 5, 2000; 192(5): 695 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-K. Park, W. S. Yang, S. K. Lee, H. Ahn, J. S. Park, O. Hwang, and J. D. Lee TGF-{beta}1 down-regulates inflammatory cytokine-induced VCAM-1 expression in cultured human glomerular endothelial cells Nephrol. Dial. Transplant., May 1, 2000; 15(5): 596 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Lucas, S.-J. Kim, S. J. Melby, and R. E. Gress Disruption of T Cell Homeostasis in Mice Expressing a T Cell-specific Dominant Negative Transforming Growth Factor {beta} II Receptor J. Exp. Med., April 3, 2000; 191(7): 1187 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Stocker, K. L. Sugars, O. A. Harari, R. C. Landis, B. J. Morley, and D. O. Haskard TNF-{alpha}, IL-4, and IFN-{gamma} Regulate Differential Expression of P- and E-Selectin Expression by Porcine Aortic Endothelial Cells J. Immunol., March 15, 2000; 164(6): 3309 - 3315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R McColm, B. J Stenson, N. Biermasz, and N. McIntosh Measurement of interleukin 10 in bronchoalveolar lavage from preterm ventilated infants Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2000; 82(2): 156F - 159. [Abstract] [Full Text]
|
|
|
|
|
|
D. Grainger, D. Mosedale, J. Metcalfe, and E. Bottinger Dietary fat and reduced levels of TGFbeta1 act synergistically to promote activation of the vascular endothelium and formation of lipid lesions J. Cell Sci., January 7, 2000; 113(13): 2355 - 2361. [Abstract] [PDF]
|
|
|
|
 |
|
 R. R. Langley, J. Russell, M. J. Eppihimer, S. J. Alexander, M. Gerritsen, R. D. Specian, and D. N. Granger Quantification of murine endothelial cell adhesion molecules in solid tumors Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H1156 - H1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Luo, G. Paranya, and J. Bischoff Noninflammatory Expression of E-Selectin Is Regulated by Cell Growth Blood, June 1, 1999; 93(11): 3785 - 3791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G V McDonnell, C W Kirk, S A Hawkins, and C A Graham Lack of association of transforming growth factor (TGF)-b1 and b2 gene polymorphisms with multiple sclerosis (MS) in Northern Ireland Multiple Sclerosis, April 1, 1999; 5(2): 105 - 109. [Abstract] [PDF]
|
|
|
|
|
|
M. Yano, B. N. Mora, J. M. Ritter, R. K. Scheule, N. S. Yew, T. Mohanakumar, and G. A. Patterson EX VIVO TRANSFECTION OF TRANSFORMING GROWTH FACTOR-{beta}1 GENE TO PULMONARY ARTERY SEGMENTS IN LUNG GRAFTS J. Thorac. Cardiovasc. Surg., April 1, 1999; 117(4): 705 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Braun, P. Pietsch, K. Schror, G. Baumann, and S. B. Felix Cellular adhesion molecules on vascular smooth muscle cells Cardiovasc Res, February 1, 1999; 41(2): 395 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, W. Jin, M. Cook, H. L. Weiner, and S. M. Wahl Oral Delivery of Group A Streptococcal Cell Walls Augments Circulating TGF-{beta} and Suppresses Streptococcal Cell Wall Arthritis J. Immunol., December 1, 1998; 161(11): 6297 - 6304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Xia, J. R. Gamble, K.-A. Rye, L. Wang, C. S. T. Hii, P. Cockerill, Y. Khew-Goodall, A. G. Bert, P. J. Barter, and M. A. Vadas Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway PNAS, November 24, 1998; 95(24): 14196 - 14201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Melrose, N. Tsurushita, G. Liu, and E. L. Berg IFN-{gamma} Inhibits Activation-Induced Expression of E- and P-Selectin on Endothelial Cells J. Immunol., September 1, 1998; 161(5): 2457 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Yoong, G. McNab, S. G. Hubscher, and D. H. Adams Vascular Adhesion Protein-1 and ICAM-1 Support the Adhesion of Tumor-Infiltrating Lymphocytes to Tumor Endothelium in Human Hepatocellular Carcinoma J. Immunol., April 15, 1998; 160(8): 3978 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Litwin, K. Clark, L. Noack, J. Furze, M. Berndt, S. Albelda, M. Vadas, and J. Gamble Novel Cytokine-independent Induction of Endothelial Adhesion Molecules Regulated by Platelet/Endothelial Cell Adhesion Molecule (CD31) J. Cell Biol., October 6, 1997; 139(1): 219 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cambien, S. Ricard, A. Troesch, C. Mallet, L. Generenaz, A. Evans, D. Arveiler, G. Luc, J.-B. Ruidavets, and O. Poirier Polymorphisms of the Transforming Growth Factor-ß1 Gene in Relation to Myocardial Infarction and Blood Pressure: The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study Hypertension, November 1, 1996; 28(5): 881 - 887. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. S. Kim, S. S. Yoon, Y. H. Kim, and J. S. Ryu Serial Measurement of Interleukin-6, Transforming Growth Factor-ß, and S-100 Protein in Patients With Acute Stroke Stroke, September 1, 1996; 27(9): 1553 - 1557. [Abstract] [Full Text]
|
|
|
|
|
|
J. Krupinski, P. Kumar, S. Kumar, and J. Kaluza Increased Expression of TGF-ß1 in Brain Tissue After Ischemic Stroke in Humans Stroke, May 1, 1996; 27(5): 852 - 857. [Abstract] [Full Text]
|
|
|
|
|
|
G. W. Cockerill, K.-A. Rye, J. R. Gamble, M. A. Vadas, and P. J. Barter High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules Arterioscler. Thromb. Vasc. Biol., November 1, 1995; 15(11): 1987 - 1994. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Gamble, S. Bradley, L. Noack, and M. A. Vadas TGF-ß and Endothelial Cells Inhibit VCAM-1 Expression on Human Vascular Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., July 1, 1995; 15(7): 949 - 955. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
