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The Primary Toxicity of Goat-Serum

From the Henry Phipps Institute, University of Pennsylvania, Philadelphia

Abstract

That the serum of certain normal animals may prove toxic when injected into normal animals of another species has long been known and a number of explanations have been offered of the mechanism involved.

Landois (1) believed that the toxicity of the serums of sheep, man, dog and cat is due to their ability to produce intravascular hemagglutination and intravascular coagulation. Leob, Strickler and Tuttle (2) concluded that the toxic action of beef-serum for rabbits is due to its hemagglutinating action, but that the toxic action of dog-serum for rabbits is due to its hemolytic action. Coca (3) believed that hemagglutination is responsible for the shock that follows the injection of washed heterologous cells.

That hemagglutination cannot be the cause of the toxic action of heterologous serum has been shown by Zinsser (4). This author found that while the hemolytic and toxic property of goat-serum for rabbits was lost when the serum was heated at 56°C. for twenty minutes, the hemagglutinative property was not affected.