| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 149, Issue 9 3073-3077, Copyright © 1992 by American Association of Immunologists
ARTICLES |
MV Blazquez, JA Madueno, R Gonzalez, R Jurado, WW Bachovchin, J Pena and E Munoz
Departamento de Bioquimica, Biologia Molecular y Fisiologia, Hospital Reina Sofia, Universidad de Cordoba, Spain.
The decrease of CD4+ cells in AIDS patients is widely documented, although the selective loss within different subsets of CD4+ cells and the mechanisms involved in this phenomenon are controversial. In the present report we have analyzed the proliferative response to Ag and mitogen of peripheral blood T lymphocytes from HIV-infected individuals, the phenotype profile of CD26+ and CD26- subset of cells and their infectivity by the HIV. The expression of CD26 Ag, either in CD4+ or CD8+ cells, was clearly diminished in all the patients tested. On the other hand, the expression of CD29 seems not to be affected, nevertheless T cells from these patients were unable to generate a proliferative response against soluble Ag. In 11 out of 13 patients, polymerase chain reaction studies demonstrated that the CD26- subset of CD4+ cells was the main reservoir for HIV-1 in infected individuals and HIV-1 virus preferentially infected in vitro CD4+/CD26- subpopulation. This capacity for preferential infectivity, together with the selective loss of cells expressing CD26 Ag, helps to explain the progressive impairment in the immune system of these patients and sheds new light on our understanding of the AIDS pathophysiology.
This article has been cited by other articles:
|
|
 |
|
  F. J. Salgado, J. Lojo, J. L. Alonso-Lebrero, C. Lluis, R. Franco, O. J. Cordero, and M. Nogueira A Role for Interleukin-12 in the Regulation of T Cell Plasma Membrane Compartmentation J. Biol. Chem., June 27, 2003; 278(27): 24849 - 24857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Boonacker, E. A. Wierenga, H. H. Smits, and C. J.F. Van Noorden CD26/DPPIV Signal Transduction Function, but Not Proteolytic Activity, Is Directly Related to Its Expression Level on Human Th1 and Th2 Cell Lines as Detected with Living Cell Cytochemistry J. Histochem. Cytochem., September 1, 2002; 50(9): 1169 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Nakayama, Y. Hoshino, X. Xin, H. Liu, M. Goto, N. Watanabe, H. Taguchi, A. Hitani, A. Kawana-Tachikawa, M. Fukushima, et al. Polymorphism in the Interleukin-4 Promoter Affects Acquisition of Human Immunodeficiency Virus Type 1 Syncytium-Inducing Phenotype J. Virol., June 15, 2000; 74(12): 5452 - 5459. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Shioda, H. Kato, Y. Ohnishi, K. Tashiro, M. Ikegawa, E. E. Nakayama, H. Hu, A. Kato, Y. Sakai, H. Liu, et al. Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha ) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage PNAS, May 26, 1998; 95(11): 6331 - 6336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bofill, L. D. Fairbanks, K. Ruckemann, M. Lipman, and H. A. Simmonds T-lymphocytes from AIDS Patients Are Unable to Synthesize Ribonucleotides de Novo in Response to Mitogenic Stimulation J. Biol. Chem., December 15, 1995; 270(50): 29690 - 29697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Callebaut, B Krust, E Jacotot, and A. Hovanessian T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells Science, December 24, 1993; 262(5142): 2045 - 2050. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
