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The Journal of Immunology, Vol 149, Issue 7 2281-2285, Copyright © 1992 by American Association of Immunologists
ARTICLES |
DI Godfrey, A Zlotnik and T Suda
DNAX Research Institute, Palo Alto, CA 94304.
We have studied the expression and function of c-kit on subsets of mouse thymocytes. c-kit was primarily expressed on subpopulations of CD4-CD8-CD3- triple negative (TN) cells. The strongest c-kit expression was associated with subsets that represent the least mature TN cells, including CD44+CD25- TN, and a subpopulation of CD25+ TN. These cells were also Thy-1lo, H-2Khi TSA-1hi, HSAlo, B220-, Mac-1-, and Gr-1-. Additionally, the recently described pre-TN thymocyte population (CD4loCD3-CD8-) was also c-kit+. CD25+ TN thymocytes proliferated in the presence of IL-7 and stem cell factor (the ligand for c-kit), and this proliferation was completely inhibited in the presence of anti-c- kit. Furthermore, the addition of anti-c-kit to 2-deoxyguanosine- treated fetal thymic lobes undergoing reconstitution with fetal liver- derived precursor cells inhibited their T cell differentiation potential. These observations indicate an important role for c-kit/stem cell factor interactions during early thymocyte development.
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