The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, J. N.
Right arrow Articles by Dudley, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, J. N.
Right arrow Articles by Dudley, J.

The Journal of Immunology, Vol 149, Issue 4 1242-1251, Copyright © 1992 by American Association of Immunologists

ARTICLES

Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream V kappa 9 gene

JN Yang and J Dudley
Department of Microbiology, University of Texas, Austin 78712.

Mtv-8 is an endogenous retrovirus located 4.6 kb upstream of a V kappa region gene (called V kappa 9M) within the kappa-Ig locus. The proximity of these two genes resulted in several effects. Using a newly developed RNase protection assay for measuring transcription from a single endogenous provirus, we found that Mtv-8 transcription could be detected after juxtaposition of the kappa-enhancers to the normally silent provirus. Reciprocally, using the polymerase chain reaction we observed that the frequency of V kappa 9M rearrangement was 5- to 10- fold higher in spleens from Mtv-8-positive mice (BALB/c, C58.C, A/J, and B6) compared to spleens from mice that lacked the Mtv-8 provirus (C58, C.C58, NZB, and PERA/Ei). Molecular cloning and sequencing of the V kappa 9M gene from C.C58 mice (containing the kappa-locus from C58 mice on a BALB/c background) indicated that at least some Mtv-8- negative strains have a functional V kappa 9M gene. Together these data suggest that Mtv-8 or a closely linked gene enhances V kappa 9M rearrangement. Since Mtv-8 also reportedly produces a superantigen, it appears that Mtv-8 may influence both the T cell and B cell repertoires.


This article has been cited by other articles:


Home page
 J. Virol.Home page
J. A. Mertz, M. S. Simper, M. M. Lozano, S. M. Payne, and J. P. Dudley
Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus
J. Virol., December 1, 2005; 79(23): 14737 - 14747.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Seo, M. M. Lozano, and J. P. Dudley
Nuclear Matrix Binding Regulates SATB1-mediated Transcriptional Repression
J. Biol. Chem., July 1, 2005; 280(26): 24600 - 24609.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Ali, M. Weinreich, S. Balcaitis, C. J. Cooper, and P. J. Fink
Differential Regulation of Peripheral CD4+ T Cell Tolerance Induced by Deletion and TCR Revision
J. Immunol., December 1, 2003; 171(11): 6290 - 6296.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Barnett, F. Mustafa, T. J. Wrona, M. Lozano, and J. P. Dudley
Expression of Mouse Mammary Tumor Virus Superantigen mRNA in the Thymus Correlates with Kinetics of Self-Reactive T-Cell Loss
J. Virol., August 1, 1999; 73(8): 6634 - 6645.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
T. J. Wrona, M. Lozano, A. A. Binhazim, and J. P. Dudley
Mutational and Functional Analysis of the C-Terminal Region of the C3H Mouse Mammary Tumor Virus Superantigen
J. Virol., June 1, 1998; 72(6): 4746 - 4755.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1992 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1992 by The American Association of Immunologists, Inc. All rights reserved.