| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 149, Issue 3 847-854, Copyright © 1992 by American Association of Immunologists
ARTICLES |
W Kasinrerk, E Fiebiger, I Stefanova, T Baumruker, W Knapp and H Stockinger
Institute of Immunology-Vienna International Research Cooperation Center, Sandoz Forschungsinstitut, Austria.
Peripheral granulocytes from rheumatoid arthritis and reactive arthritis patients were recently found to express higher levels of a newly defined Ag, termed M6, in comparison to granulocytes from healthy subjects. We present here the molecular characterization of M6 Ag and show that it is a novel human leukocyte activation-associated cell surface glycoprotein. Peripheral lymphocytes do not significantly express M6 Ag, however, it appears upon 3-day PHA-activated T blasts. On monocytes, which constitutively express M6 Ag, it is down-regulated on day 1 but re-induced on day 3 of granulocyte-macrophage CSF stimulation. SDS-PAGE analysis of M6 immunoprecipitates shows a single band of 54 kDa under nonreducing conditions that shifts to 65 kDa under reducing conditions. Endoglycosidase F treatment of M6 immunoprecipitate reveals that 50% of the M6 molecule is composed of N- linked carbohydrates. By modifying the COS cell cloning strategy, we have isolated cDNA clones encoding M6 Ag. M6 cDNA hybridizes with a single mRNA transcript of approximately 1.7 kb in Northern blotting. Comparison analysis of the M6 sequence indicates that M6 Ag is a member of the Ig superfamily and the species homologue of rat OX-47 Ag, mouse basigin (gp42), and chicken HT7 molecule. The highly conserved remarkable transmembrane domain suggests that the M6 Ag may be a component of a multichain complex in the plasma membrane.
This article has been cited by other articles:
|
|
 |
|
  K. S. Vetrivel, X. Zhang, X. Meckler, H. Cheng, S. Lee, P. Gong, K. O. Lopes, Y. Chen, N. Iwata, K.-J. Yin, et al. Evidence That CD147 Modulation of {beta}-Amyloid (A{beta}) Levels Is Mediated by Extracellular Degradation of Secreted A{beta} J. Biol. Chem., July 11, 2008; 283(28): 19489 - 19498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Belton Jr., L. Chen, F. S. Mesquita, and R. A. Nowak Basigin-2 Is a Cell Surface Receptor for Soluble Basigin Ligand J. Biol. Chem., June 27, 2008; 283(26): 17805 - 17814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Damsker, M. I. Bukrinsky, and S. L. Constant Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A J. Leukoc. Biol., September 1, 2007; 82(3): 613 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Egawa, N. Koshikawa, T. Tomari, K. Nabeshima, T. Isobe, and M. Seiki Membrane Type 1 Matrix Metalloproteinase (MT1-MMP/MMP-14) Cleaves and Releases a 22-kDa Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Fragment from Tumor Cells J. Biol. Chem., December 8, 2006; 281(49): 37576 - 37585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Gwinn, J. M. Damsker, R. Falahati, I. Okwumabua, A. Kelly-Welch, A. D. Keegan, C. Vanpouille, J. J. Lee, L. A. Dent, D. Leitenberg, et al. Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention J. Immunol., October 1, 2006; 177(7): 4870 - 4879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Intasai, S. Mai, W. Kasinrerk, and C. Tayapiwatana Binding of multivalent CD147 phage induces apoptosis of U937 cells Int. Immunol., July 1, 2006; 18(7): 1159 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rudajev, J. Novotny, L. Hejnova, G. Milligan, and P. Svoboda Dominant Portion of Thyrotropin-Releasing Hormone Receptor Is Excluded from Lipid Domains. Detergent-Resistant and Detergent-Sensitive Pools of TRH Receptor and Gq{alpha}/G11{alpha} Protein J. Biochem., August 1, 2005; 138(2): 111 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Tang, S. B. Chang, and M. E. Hemler Links between CD147 Function, Glycosylation, and Caveolin-1 Mol. Biol. Cell, September 1, 2004; 15(9): 4043 - 4050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Deora, D. Gravotta, G. Kreitzer, J. Hu, D. Bok, and E. Rodriguez-Boulan The Basolateral Targeting Signal of CD147 (EMMPRIN) Consists of a Single Leucine and Is Not Recognized by Retinal Pigment Epithelium Mol. Biol. Cell, September 1, 2004; 15(9): 4148 - 4165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Li, N. Alfaidy, and J. R. G. Challis Expression of Extracellular Matrix Metalloproteinase Inducer in Human Placenta and Fetal Membranes at Term Labor J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2897 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Saxena and K. Toshimori Molecular Modifications of MC31/CE9, a Sperm Surface Molecule, During Sperm Capacitation and the Acrosome Reaction in the Rat: Is MC31/CE9 Required for Fertilization? Biol Reprod, April 1, 2004; 70(4): 993 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tang and M. E. Hemler Caveolin-1 Regulates Matrix Metalloproteinases-1 Induction and CD147/EMMPRIN Cell Surface Clustering J. Biol. Chem., March 19, 2004; 279(12): 11112 - 11118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Laudes, C. Christodoulides, C. Sewter, J. J. Rochford, R. V. Considine, J. K. Sethi, A. Vidal-Puig, and S. O'Rahilly Role of the POZ Zinc Finger Transcription Factor FBI-1 in Human and Murine Adipogenesis J. Biol. Chem., March 19, 2004; 279(12): 11711 - 11718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Noguchi, T. Sato, M. Hirata, T. Hara, K. Ohama, and A. Ito Identification and Characterization of Extracellular Matrix Metalloproteinase Inducer in Human Endometrium during the Menstrual Cycle in Vivo and in Vitro J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 6063 - 6072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ochrietor, T. P. Moroz, L. van Ekeris, M. F. Clamp, S. C. Jefferson, A. C. deCarvalho, J. M. Fadool, G. Wistow, T. Muramatsu, and P. J. Linser Retina-Specific Expression of 5A11/Basigin-2, a Member of the Immunoglobulin Gene Superfamily Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 4086 - 4096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Staffler, A. Szekeres, G. J. Schutz, M. D. Saemann, E. Prager, M. Zeyda, K. Drbal, G. J. Zlabinger, T. M. Stulnig, and H. Stockinger Selective Inhibition of T Cell Activation Via CD147 Through Novel Modulation of Lipid Rafts J. Immunol., August 15, 2003; 171(4): 1707 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Wilson, D. Meredith, and A. P. Halestrap Fluorescence Resonance Energy Transfer Studies on the Interaction between the Lactate Transporter MCT1 and CD147 Provide Information on the Topology and Stoichiometry of the Complex in Situ J. Biol. Chem., January 25, 2002; 277(5): 3666 - 3672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Jiang, Q. Zhou, M. K. Yu, L. S. Ho, Z. N. Chen, and H. C. Chan The Involvement of HAb18G/CD147 in Regulation of Store-operated Calcium Entry and Metastasis of Human Hepatoma Cells J. Biol. Chem., December 7, 2001; 276(50): 46870 - 46877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wille, A. Szekeres, O. Majdic, E. Prager, G. Staffler, J. Stockl, D. Kunthalert, E. E. Prieschl, T. Baumruker, H. Burtscher, et al. Characterization of CDw92 as a Member of the Choline Transporter-Like Protein Family Regulated Specifically on Dendritic Cells J. Immunol., November 15, 2001; 167(10): 5795 - 5804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Coste, J.-F. Gauchat, A. Wilson, S. Izui, P. Jeannin, Y. Delneste, H. R. MacDonald, J.-Y. Bonnefoy, and T. Renno Unavailability of CD147 leads to selective erythrocyte trapping in the spleen Blood, June 15, 2001; 97(12): 3984 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zucker, M. Hymowitz, E. E. Rollo, R. Mann, C. E. Conner, J. Cao, H. D. Foda, D. C. Tompkins, and B. P. Toole Tumorigenic Potential of Extracellular Matrix Metalloproteinase Inducer Am. J. Pathol., June 1, 2001; 158(6): 1921 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sun and M. E. Hemler Regulation of MMP-1 and MMP-2 Production through CD147/Extracellular Matrix Metalloproteinase Inducer Interactions Cancer Res., March 1, 2001; 61(5): 2276 - 2281. [Abstract] [Full Text]
|
|
|
|
|
|
K. Hori, N. Katayama, S. Kachi, M. Kondo, K. Kadomatsu, J. Usukura, T. Muramatsu, S. Mori, and Y. Miyake Retinal Dysfunction in Basigin Deficiency Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3128 - 3133. [Abstract] [Full Text]
|
|
|
|
|
|
R. Huttinger, G. Staffler, O. Majdic, and H. Stockinger Analysis of the early biogenesis of CD1b: involvement of the chaperones calnexin and calreticulin, the proteasome and {beta}2-microglobulin Int. Immunol., October 1, 1999; 11(10): 1615 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Koch, G. Staffler, R. Huttinger, I. Hilgert, E. Prager, J. Cerny, P. Steinlein, O. Majdic, V. Horejsi, and H. Stockinger T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density Int. Immunol., May 1, 1999; 11(5): 777 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Berditchevski, S. Chang, J. Bodorova, and M. E. Hemler Generation of Monoclonal Antibodies to Integrin-associated Proteins. EVIDENCE THAT alpha 3beta 1 COMPLEXES WITH EMMPRIN/BASIGIN/OX47/M6 J. Biol. Chem., November 14, 1997; 272(46): 29174 - 29180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Polette, C. Gilles, V. Marchand, M. Lorenzato, B. Toole, J.-M. Tournier, S. Zucker, and P. Birembaut Tumor Collagenase Stimulatory Factor (TCSF) Expression and Localization in Human Lung and Breast Cancers J. Histochem. Cytochem., May 1, 1997; 45(5): 703 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Langnaese, P. W. Beesley, and E. D. Gundelfinger Synaptic Membrane Glycoproteins gp65 and gp55 Are New Members of the Immunoglobulin Superfamily J. Biol. Chem., January 10, 1997; 272(2): 821 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Guo, S. Zucker, M. K. Gordon, B. P. Toole, and C. Biswas Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells J. Biol. Chem., January 3, 1997; 272(1): 24 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cesario and J. Bartles Compartmentalization, processing and redistribution of the plasma membrane protein CE9 on rodent spermatozoa. Relationship of the annulus to domain boundaries in the plasma membrane of the tail J. Cell Sci., January 2, 1994; 107(2): 561 - 570. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
