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The Journal of Immunology, Vol 148, Issue 8 2462-2468, Copyright © 1992 by American Association of Immunologists
ARTICLES |
RP Taylor, CJ Reist, WM Sutherland, A Otto, RH Labuguen and EL Wright
Department of Biochemistry, University of Virginia, School of Medicine, Charlottesville 22908.
We have used the avidin/biotin system to construct soluble, cross- linked bispecific heteropolymers containing mAb to both the primate E C receptor and the DNP group. These heteropolymers facilitate in vitro binding of DNP-bovine gamma-globulin (DNP-BGG) to both human and squirrel monkey E. Intravenous injection in squirrel monkeys of DNP-BGG followed by heteropolymer leads to E binding and clearance from the circulation of a significant fraction of both heteropolymer and DNP- BGG, without lysis or clearance of the E. This methodology may potentially be used to treat a variety of infectious diseases and other syndromes associated with blood-borne pathogens.
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