The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saito, M.
Right arrow Articles by Kishimoto, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saito, M.
Right arrow Articles by Kishimoto, T.

The Journal of Immunology, Vol 148, Issue 12 4066-4071, Copyright © 1992 by American Association of Immunologists

ARTICLES

Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo

M Saito, K Yoshida, M Hibi, T Taga and T Kishimoto
Division of Immunology, Institute for Molecular and Cellular Biology, Osaka University, Japan.

The IL-6R system comprises two functionally different chains: a ligand binding-chain (IL-6R) and a non-ligand-binding but signal-transducing chain (gp130). gp130 associates with the IL-6-IL-6R complex, resulting in the formation of high-affinity IL-6 binding sites, and transduces the signal. A cDNA for murine gp130 has been cloned from the cDNA library of murine macrophages by using a human gp130 cDNA as a probe. The overall homology with human gp130 was 76.8% at the protein level. The extracellular region of murine gp130, as observed in human gp130, comprises 6 U of a fibronectin type III module and part of this region of approximately 200 amino acids has typical features of a cytokine receptor family. Cloned murine gp130 could transduce the growth signal in a murine IL-3-dependent cell line in response to a complex of IL-6 and soluble IL-6R. Two species of murine gp130 mRNA (7 and 10 kb) were expressed in almost all the cell lines. These transcripts were also ubiquitously expressed in murine tissues, embryonic stem cells, and embryos as early as day 6 of gestation. Administration of IL-6 in mouse caused up-regulation of the gp130 mRNA levels in several tissues. Both gp130 and IL-6R mRNA in liver were up-regulated in vivo by IL-6.


This article has been cited by other articles:


Home page
 JDRHome page
K. Iwasaki, M. Komaki, K. Mimori, E. Leon, Y. Izumi, and I. Ishikawa
IL-6 Induces Osteoblastic Differentiation of Periodontal Ligament Cells
Journal of Dental Research, October 1, 2008; 87(10): 937 - 942.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. H. Mortensen, K. Andersen, C. Fischer, A. R. Nielsen, S. Nielsen, T. Akerstrom, M.-b. Aastrom, R. Borup, and B. K. Pedersen
Calprotectin is released from human skeletal muscle tissue during exercise
J. Physiol., July 15, 2008; 586(14): 3551 - 3562.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. M. Briso, O. Dienz, and M. Rincon
Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells
J. Immunol., June 1, 2008; 180(11): 7102 - 7106.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Pavel, K. Nadella, W. H. Towns II, and L. S. Kirschner
Mutation of Prkar1a Causes Osteoblast Neoplasia Driven by Dysregulation of Protein Kinase A
Mol. Endocrinol., February 1, 2008; 22(2): 430 - 440.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. E. Davey, K. Onishi, A. Mahdavi, and P. W. Zandstra
LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop
FASEB J, July 1, 2007; 21(9): 2020 - 2032.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. Maggio, J. M. Guralnik, D. L. Longo, and L. Ferrucci
Interleukin-6 in aging and chronic disease: a magnificent pathway.
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 575 - 584.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
H. Song and H. Lim
Evidence for heterodimeric association of leukemia inhibitory factor (LIF) receptor and gp130 in the mouse uterus for LIF signaling during blastocyst implantation
Reproduction, February 1, 2006; 131(2): 341 - 349.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Keller, A. Steensberg, A. K. Hansen, C. P. Fischer, P. Plomgaard, and B. K. Pedersen
Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle
J Appl Physiol, December 1, 2005; 99(6): 2075 - 2079.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens
Cross-talk among gp130 Cytokines in Adipocytes
J. Biol. Chem., October 7, 2005; 280(40): 33856 - 33863.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. Bruunsgaard
Physical activity and modulation of systemic low-level inflammation
J. Leukoc. Biol., October 1, 2005; 78(4): 819 - 835.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. Q. Zhang, C. Okumura, T. McCarty, M. S. Shin, P. Mukhopadhyay, M. Hori, T. A. Torrey, Z. Naghashfar, J. X. Zhou, C. H. Lee, et al.
Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl
J. Exp. Med., December 6, 2004; 200(11): 1467 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Yoshida, T. Harada, T. Iwabe, F. Taniguchi, M. Mitsunari, N. Yamauchi, I. Deura, S. Horie, and N. Terakawa
A combination of interleukin-6 and its soluble receptor impairs sperm motility: implications in infertility associated with endometriosis
Hum. Reprod., August 1, 2004; 19(8): 1821 - 1825.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Bernardo, C. Ball, L. Nolasco, J. F. Moake, and J.-f. Dong
Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow
Blood, July 1, 2004; 104(1): 100 - 106.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. A. Molyneaux, K. Schaible, and C. Wylie
GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation
Development, September 15, 2003; 130(18): 4287 - 4294.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Underhill-Day, L. A. McGovern, N. Karpovich, H. J. Mardon, V. A. Barton, and J. K. Heath
Functional Characterization of W147A: A High-Affinity Interleukin-11 Antagonist
Endocrinology, August 1, 2003; 144(8): 3406 - 3414.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. P. Castro, D. Giacomini, A. C. Nagashima, C. Onofri, M. Graciarena, K. Kobayashi, M. Paez-Pereda, U. Renner, G. K. Stalla, and E. Arzt
Reduced Expression of the Cytokine Transducer gp130 Inhibits Hormone Secretion, Cell Growth, and Tumor Development of Pituitary Lactosomatotrophic GH3 Cells
Endocrinology, February 1, 2003; 144(2): 693 - 700.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. Tsutamoto, A. Wada, K. Maeda, N. Mabuchi, M. Hayashi, T. Tsutsui, M. Ohnishi, M. Fujii, T. Matsumoto, T. Yamamoto, et al.
Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1485 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P.-C. LAI, H. T. COOK, J. SMITH, J. C. KEITH JR., C. D. PUSEY, and F. W. K. TAM
Interleukin-11 Attenuates Nephrotoxic Nephritis in Wistar Kyoto Rats
J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2310 - 2320.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. K. Pedersen, A. Steensberg, and P. Schjerling
Muscle-derived interleukin-6: possible biological effects
J. Physiol., October 15, 2001; 536(2): 329 - 337.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Ernst, M. Inglese, P. Waring, I. K. Campbell, S. Bao, F. J. Clay, W. S. Alexander, I. P. Wicks, D. M. Tarlinton, U. Novak, et al.
Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation
J. Exp. Med., July 16, 2001; 194(2): 189 - 204.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-G. Cheng, J. R. Chen, L. Hernandez, W. G. Alvord, and C. L. Stewart
Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation
PNAS, June 28, 2001; (2001) 151180898.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Billia, M. Barbara, J. McEwen, M. Trevisan, and N. N. Iscove
Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts
Blood, April 15, 2001; 97(8): 2257 - 2268.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Menetrier-Caux, M. C. Thomachot, L. Alberti, G. Montmain, and J. Y. Blay
IL-4 Prevents the Blockade of Dendritic Cell Differentiation Induced by Tumor Cells
Cancer Res., April 1, 2001; 61(7): 3096 - 3104.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
FASEB J, January 1, 2001; 15(1): 43 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. J. Auernhammer and S. Melmed
Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function
Endocr. Rev., June 1, 2000; 21(3): 313 - 345.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
T. Ezure, T. Sakamoto, H. Tsuji, J. G. Lunz III, N. Murase, J. J. Fung, and A. J. Demetris
The Development and Compensation of Biliary Cirrhosis in Interleukin-6-Deficient Mice
Am. J. Pathol., May 1, 2000; 156(5): 1627 - 1639.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Vallières and S. Rivest
Interleukin-6 Is a Needed Proinflammatory Cytokine in the Prolonged Neural Activity and Transcriptional Activation of Corticotropin-Releasing Factor during Endotoxemia
Endocrinology, September 1, 1999; 140(9): 3890 - 3903.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. A. O'Brien, I. Gubrij, S.-C. Lin, R. L. Saylors, and S. C. Manolagas
STAT3 Activation in Stromal/Osteoblastic Cells Is Required for Induction of the Receptor Activator of NF-kappa B Ligand and Stimulation of Osteoclastogenesis by gp130-utilizing Cytokines or Interleukin-1 but Not 1,25-Dihydroxyvitamin D3 or Parathyroid Hormone
J. Biol. Chem., July 2, 1999; 274(27): 19301 - 19308.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Sui, K. Tsuji, Y. Ebihara, R. Tanaka, K. Muraoka, M. Yoshida, K. Yamada, K. Yasukawa, T. Taga, T. Kishimoto, et al.
Soluble Interleukin-6 (IL-6) Receptor With IL-6 Stimulates Megakaryopoiesis From Human CD34+ Cells Through Glycoprotein (gp)130 Signaling
Blood, April 15, 1999; 93(8): 2525 - 2532.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. A. Barton, K. R. Hudson, and J. K. Heath
Identification of Three Distinct Receptor Binding Sites of Murine Interleukin-11
J. Biol. Chem., February 26, 1999; 274(9): 5755 - 5761.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Dubois, C. Massacrier, B. Vanbervliet, J. Fayette, F. Briere, J. Banchereau, and C. Caux
Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes
J. Immunol., September 1, 1998; 161(5): 2223 - 2231.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X.-J. Wang, T. Taga, K. Yoshida, M. Saito, T. Kishimoto, and H. Kikutani
gp130, The Cytokine Common Signal-Transducer of Interleukin-6 Cytokine Family, Is Downregulated in T Cells In Vivo by Interleukin-6
Blood, May 1, 1998; 91(9): 3308 - 3314.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M Geissen, S Heller, D Pennica, U Ernsberger, and H Rohrer
The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling
Development, January 12, 1998; 125(23): 4791 - 4801.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. YOKOYAMA, N. KOHNO, K. SAKAI, K.-I. KONDO, Y. HIRASAWA, and K. HIWADA
Circulating Levels of Soluble Interleukin-6 Receptor in Patients with Bronchial Asthma
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1688 - 1691.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. A. O'Brien and S. C. Manolagas
Isolation and Characterization of the Human gp130 Promoter. REGULATION BY STATS
J. Biol. Chem., June 6, 1997; 272(23): 15003 - 15010.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Ghilardi and R. C. Skoda
The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line
Mol. Endocrinol., April 1, 1997; 11(4): 393 - 399.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Kumanogoh, S. Marukawa, T. Kumanogoh, H. Hirota, K. Yoshida, I.-S. Lee, T. Yasui, K. Yoshida, T. Taga, and T. Kishimoto
Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130
PNAS, March 18, 1997; 94(6): 2478 - 2482.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
U Koshimizu, T Taga, M Watanabe, M Saito, Y Shirayoshi, T Kishimoto, and N Nakatsuji
Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells
Development, January 4, 1996; 122(4): 1235 - 1242.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
L. S. Argetsinger, G. W. Hsu, M. G. Myers Jr., N. Billestrup, M. F. White, and C. Carter-Su
Growth Hormone, Interferon-[IMAGE], and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1
J. Biol. Chem., June 16, 1995; 270(24): 14685 - 14692.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Pennica, K. J. Shaw, T. A. Swanson, M. W. Moore, D. L. Shelton, K. A. Zioncheck, A. Rosenthal, T. Taga, N. F. Paoni, and W. I. Wood
Cardiotrophin-1
J. Biol. Chem., May 5, 1995; 270(18): 10915 - 10922.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L Cheng, D. Gearing, L. White, D. Compton, K Schooley, and P. Donovan
Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth
Development, January 11, 1994; 120(11): 3145 - 3153.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
R. L. Moritz, N. E. Hall, L. M. Connolly, and R. J. Simpson
Determination of the Disulfide Structure and N-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130
J. Biol. Chem., March 9, 2001; 276(11): 8244 - 8253.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-G. Cheng, J. R. Chen, L. Hernandez, W. G. Alvord, and C. L. Stewart
Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation
PNAS, July 17, 2001; 98(15): 8680 - 8685.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1992 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1992 by The American Association of Immunologists, Inc. All rights reserved.