| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 148, Issue 10 3244-3248, Copyright © 1992 by American Association of Immunologists
ARTICLES |
AW Cheever, FD Finkelman, P Caspar, S Heiny, JG Macedonia and A Sher
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Granulomas around Schistosoma mansoni eggs are a principal cause of morbidity in mice infected with this helminth. In vivo treatment of infected mice with anti-IL-2 antibodies, with or without anti-IL-2 receptor antibodies, significantly diminished the size of circumoval granulomas in the liver and decreased hepatic fibrosis to half that in untreated mice. Antibody-treated animals also displayed a marked reduction in both peripheral blood and tissue eosinophilia while IgE levels were unchanged or increased. Spleen cell cytokine production in response to Ag or mitogen stimulation was selectively altered by in vivo anti-IL-2 administration. IL-5 responses were dramatically reduced, whereas IL-4, IL-2, and IFN-gamma responses were not consistently changed. These findings confirm previous observations, suggesting a role for IL-2 in egg-induced pathology but indicate that the primary function of this cytokine in schistosome-infected mice may be in the generation of Th2- rather than Th1-associated responses.
This article has been cited by other articles:
|
|
 |
|
  M. M. Mentink-Kane, A. W. Cheever, R. W. Thompson, D. M. Hari, N. B. Kabatereine, B. J. Vennervald, J. H. Ouma, J. K. Mwatha, F. M. Jones, D. D. Donaldson, et al. IL-13 receptor {alpha} 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis PNAS, January 13, 2004; 101(2): 586 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Stavitsky Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis Infect. Immun., January 1, 2004; 72(1): 1 - 12. [Full Text] [PDF]
|
|
|
|
 |
|
 L. I. Rutitzky, G. A. Mirkin, and M. J. Stadecker Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis J. Immunol., August 15, 2003; 171(4): 1859 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. O. Farah, P. W. Mola, T. M. Kariuki, M. Nyindo, R. E. Blanton, and C. L. King Repeated Exposure Induces Periportal Fibrosis in Schistosoma mansoni-Infected Baboons: Role of TGF-{beta} and IL-4 J. Immunol., May 15, 2000; 164(10): 5337 - 5343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lohning, J. L. Grogan, A. J. Coyle, M. Yazdanbakhsh, C. Meisel, J.-C. Gutierrez-Ramos, A. Radbruch, and T. Kamradt T1/ST2 Expression Is Enhanced on CD4+ T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo J. Immunol., April 1, 1999; 162(7): 3882 - 3889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yang, J. Gartner, L. Zhu, S. Wang, and R. C. Brunham IL-10 Gene Knockout Mice Show Enhanced Th1-Like Protective Immunity and Absent Granuloma Formation Following Chlamydia trachomatis Lung Infection J. Immunol., January 15, 1999; 162(2): 1010 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Montesano, D. G. Colley, M. T. Willard, G. L. Freeman Jr., and W. E. Secor Idiotypes Expressed Early in Experimental Schistosoma mansoni Infections Predict Clinical Outcomes of Chronic Disease J. Exp. Med., May 6, 2002; 195(9): 1223 - 1228. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
