| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 148, Issue 10 3110-3116, Copyright © 1992 by American Association of Immunologists
ARTICLES |
N Yoshizawa, S Oshima, I Sagel, J Shimizu and G Treser
Second Department of Medicine, National Defense Medical College, Tokorozawa, Japan.
We studied the significance of a streptococcal protein (preabsorbing Ag) (PA-Ag) in the pathogenesis of acute poststreptococcal glomerulonephritis (APSGN). This protein was isolated from nephritogenic streptococci. Purification of PA-Ag was achieved by chromatography, followed by Sephadex IEF. A single protein band at pH 4.7 was identified as PA-Ag. The m.w. was 43,000. Rabbit antisera against PA-Ag and sera of patients with APSGN showed identical precipitation lines by immunodiffusion. Antibodies to PA-Ag were found to be present in 30 of 31 patients with APSGN, in 1 of 36 patients with uncomplicated group A streptococcal upper respiratory tract infections, and in 1 of 36 normal adults. By using immunoelectrophoresis, it was found that PA-Ag activates the alternate pathway of C. Other water- soluble streptococcal fractions, used as controls, did not activate the C system. The demonstration that PA-Ag is present in the glomeruli in the early phase of APSGN and its ability to activate C3 and factor B suggest that PA-Ag may be involved in the pathogenesis of APSGN, via in situ C activation.
This article has been cited by other articles:
|
|
 |
|
  T. Oda, K. Yamakami, F. Omasu, S. Suzuki, S. Miura, T. Sugisaki, and N. Yoshizawa Glomerular Plasmin-Like Activity in Relation to Nephritis-Associated Plasmin Receptor in Acute Poststreptococcal Glomerulonephritis J. Am. Soc. Nephrol., January 1, 2005; 16(1): 247 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yoshizawa, K. Yamakami, M. Fujino, T. Oda, K. Tamura, K. Matsumoto, T. Sugisaki, and M. D.P. Boyle Nephritis-Associated Plasmin Receptor and Acute Poststreptococcal Glomerulonephritis: Characterization of the Antigen and Associated Immune Response J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1785 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nordstrand, W. M. McShan, J. J. Ferretti, S. E. Holm, and M. Norgren Allele Substitution of the Streptokinase Gene Reduces the Nephritogenic Capacity of Group A Streptococcal Strain NZ131 Infect. Immun., March 1, 2000; 68(3): 1019 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Cunningham, L. Hodge, D. Speicher, D. Reim, C. Tyler-Polsz, P. Levitt, K. Eagleson, S. Kennedy, and Y. Wang Identification of a Survival-Promoting Peptide in Medium Conditioned by Oxidatively Stressed Cell Lines of Nervous System Origin J. Neurosci., September 15, 1998; 18(18): 7047 - 7060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Boisgerault, J. Mounier, V. Tieng, M.-C. Stolzenberg, I. Khalil-Daher, M. Schmid, P. Sansonetti, D. Charron, and A. Toubert Alteration of HLA-B27 Peptide Presentation after Infection of Transfected Murine L Cells by Shigella flexneri Infect. Immun., September 1, 1998; 66(9): 4484 - 4490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nordstrand, M. Norgren, J. J. Ferretti, and S. E. Holm Streptokinase as a Mediator of Acute Post-Streptococcal Glomerulonephritis in an Experimental Mouse Model Infect. Immun., January 1, 1998; 66(1): 315 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Borregaard and J. B. Cowland Granules of the Human Neutrophilic Polymorphonuclear Leukocyte Blood, May 15, 1997; 89(10): 3503 - 3521. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
