The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Debrick, J. E.
Right arrow Articles by Staerz, U. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Debrick, J. E.
Right arrow Articles by Staerz, U. D.

The Journal of Immunology, Vol 147, Issue 9 2846-2851, Copyright © 1991 by American Association of Immunologists

ARTICLES

Macrophages as accessory cells for class I MHC-restricted immune responses

JE Debrick, PA Campbell and UD Staerz
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

Ag do not elicit T lymphocyte responses unless they are presented in conjunction with MHC molecules on the surface of an appropriate APC. In the case of CD4+ T lymphocytes dendritic cells can deliver all signals required for complete induction as can macrophages and (activated) B cells. The function of CTL also depends on the presence of specialized accessory cells. Here we show that these accessory cells can behave like scavenger cells. They use foreign Ag in the form of cellular debris as immunogen. They are also crucial for CTL induction because in vivo depletion of phagocytotic cells completely inhibits CTL responses. In these animals CTL activity could be restored by transfer of macrophages. All of the reappearing CTL used MHC restriction elements expressed by the infused macrophages. These experiments suggest that a cognate interaction between macrophages and CTL precursors initiates class I MHC-restricted immune responses.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
D. Martinez, M. Vermeulen, A. Trevani, A. Ceballos, J. Sabatte, R. Gamberale, M. E. Alvarez, G. Salamone, T. Tanos, O. A. Coso, et al.
Extracellular Acidosis Induces Neutrophil Activation by a Mechanism Dependent on Activation of Phosphatidylinositol 3-Kinase/Akt and ERK Pathways
J. Immunol., January 15, 2006; 176(2): 1163 - 1171.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L.-A. M. Pozzi, J. W. Maciaszek, and K. L. Rock
Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells
J. Immunol., August 15, 2005; 175(4): 2071 - 2081.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Hon, A. Oran, T. Brocker, and J. Jacob
B Lymphocytes Participate in Cross-Presentation of Antigen following Gene Gun Vaccination
J. Immunol., May 1, 2005; 174(9): 5233 - 5242.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. F. Grosso, L. M. Herbert, J. L. Owen, and D. M. Lopez
MUC1/sec-Expressing Tumors Are Rejected In Vivo by a T Cell-Dependent Mechanism and Secrete High Levels of CCL2
J. Immunol., August 1, 2004; 173(3): 1721 - 1730.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. Goldmann, M. Rohde, G. S. Chhatwal, and E. Medina
Role of Macrophages in Host Resistance to Group A Streptococci
Infect. Immun., May 1, 2004; 72(5): 2956 - 2963.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. C. Baker-LePain, M. Sarzotti, and C. V. Nicchitta
Glucose-Regulated Protein 94/Glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production In Vivo
J. Immunol., April 1, 2004; 172(7): 4195 - 4203.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Serna, M. C. Ramirez, A. Soukhanova, and L. J. Sigal
Cutting Edge: Efficient MHC Class I Cross-Presentation during Early Vaccinia Infection Requires the Transfer of Proteasomal Intermediates between Antigen Donor and Presenting Cells
J. Immunol., December 1, 2003; 171(11): 5668 - 5672.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. C. Ramirez and L. J. Sigal
Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells
J. Immunol., December 15, 2002; 169(12): 6733 - 6742.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Chen, J. A. Fairley, M.-L. Zhao, G. J. Giudice, D. Zillikens, L. A. Diaz, and Z. Liu
Macrophages, But Not T and B Lymphocytes, Are Critical for Subepidermal Blister Formation in Experimental Bullous Pemphigoid: Macrophage-Mediated Neutrophil Infiltration Depends on Mast Cell Activation
J. Immunol., October 1, 2002; 169(7): 3987 - 3992.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Tsung, J. P. Dolan, Y. L. Tsung, and J. A. Norton
Macrophages as Effector Cells in Interleukin 12-induced T Cell-dependent Tumor Rejection
Cancer Res., September 1, 2002; 62(17): 5069 - 5075.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. A. Pulaski, M. J. Smyth, and S. Ostrand-Rosenberg
Interferon-{gamma}-dependent Phagocytic Cells Are a Critical Component of Innate Immunity against Metastatic Mammary Carcinoma
Cancer Res., August 1, 2002; 62(15): 4406 - 4412.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Miconnet, I. Coste, F. Beermann, J.-F. Haeuw, J.-C. Cerottini, J.-Y. Bonnefoy, P. Romero, and T. Renno
Cancer Vaccine Design: A Novel Bacterial Adjuvant for Peptide-Specific CTL Induction
J. Immunol., April 1, 2001; 166(7): 4612 - 4619.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
L. L. Lenz, E. A. Butz, and M. J. Bevan
Requirements for Bone Marrow-derived Antigen-presenting Cells in Priming Cytotoxic T Cell Responses to Intracellular Pathogens
J. Exp. Med., October 16, 2000; 192(8): 1135 - 1142.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Peppelenbosch, M. DeSmedt, G. Pynaert, S. J. H. van Deventer, and J. Grooten
Macrophages Present Pinocytosed Exogenous Antigen Via MHC Class I Whereas Antigen Ingested by Receptor-Mediated Endocytosis Is Presented Via MHC Class II
J. Immunol., August 15, 2000; 165(4): 1984 - 1991.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Ma and J. A. Kapp
Antigenic Epitopes Regulate the Phenotype of CD8+ CTL Primed by Exogenous Antigens
J. Immunol., June 1, 2000; 164(11): 5698 - 5703.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Blanas, G. M. Davey, F. R. Carbone, and W. R. Heath
A Bone Marrow-Derived APC in the Gut-Associated Lymphoid Tissue Captures Oral Antigens and Presents Them to Both CD4+ and CD8+ T Cells
J. Immunol., March 15, 2000; 164(6): 2890 - 2896.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. J. Campbell, T. Serwold, and N. Shastri
Bacterial Proteins Can Be Processed by Macrophages in a Transporter Associated with Antigen Processing-Independent, Cysteine Protease-Dependent Manner for Presentation by MHC Class I Molecules
J. Immunol., January 1, 2000; 164(1): 168 - 175.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Yamazaki, T. Nguyen, and E. R. Podack
Cutting Edge: Tumor Secreted Heat Shock-Fusion Protein Elicits CD8 Cells for Rejection
J. Immunol., November 15, 1999; 163(10): 5178 - 5182.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Ronchetti, P. Rovere, G. Iezzi, G. Galati, S. Heltai, M. P. Protti, M. P. Garancini, A. A. Manfredi, C. Rugarli, and M. Bellone
Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines
J. Immunol., July 1, 1999; 163(1): 130 - 136.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
H. Singh-Jasuja, R. E.M. Toes, P. Spee, C. Munz, N. Hilf, S. P. Schoenberger, P. Ricciardi-Castagnoli, J. Neefjes, H.-G. Rammensee, D. Arnold-Schild, et al.
Cross-Presentation of Glycoprotein 96-associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-mediated Endocytosis
J. Exp. Med., June 6, 1999; 191(11): 1965 - 1974.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Liebana, R. M. Girvin, M. Welsh, S. D. Neill, and J. M. Pollock
Generation of CD8+ T-Cell Responses to Mycobacterium bovis and Mycobacterial Antigen in Experimental Bovine Tuberculosis
Infect. Immun., March 1, 1999; 67(3): 1034 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. J. Sigal, H. Reiser, and K. L. Rock
The Role of B7-1 and B7-2 Costimulation for the Generation of CTL Responses In Vivo
J. Immunol., September 15, 1998; 161(6): 2740 - 2745.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K.-Y. Yeh, A. J. McAdam, B. A. Pulaski, N. Shastri, J. G. Frelinger, and E. M. Lord
IL-3 Enhances Both Presentation of Exogenous Particulate Antigen in Association with Class I Major Histocompatibility Antigen and Generation of Primary Tumor-Specific Cytolytic T Lymphocytes
J. Immunol., June 15, 1998; 160(12): 5773 - 5780.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. R.M. Bennett, F. R. Carbone, F. Karamalis, J. F.A.P. Miller, and W. R. Heath
Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help
J. Exp. Med., July 7, 1997; 186(1): 65 - 70.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T. Kundig, M. Bachmann, C DiPaolo, J. Simard, M Battegay, H Lother, A Gessner, K Kuhlcke, P. Ohashi, H Hengartner, et al.
Fibroblasts as efficient antigen-presenting cells in lymphoid organs
Science, June 2, 1995; 268(5215): 1343 - 1347.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
T Lang, C de Chastellier, C Frehel, R Hellio, P Metezeau, S. Leao, and J. Antoine
Distribution of MHC class I and of MHC class II molecules in macrophages infected with Leishmania amazonensis
J. Cell Sci., January 1, 1994; 107(1): 69 - 82.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.