The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Voraberger, G.
Right arrow Articles by Stratowa, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Voraberger, G.
Right arrow Articles by Stratowa, C.

The Journal of Immunology, Vol 147, Issue 8 2777-2786, Copyright © 1991 by American Association of Immunologists

ARTICLES

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester

G Voraberger, R Schafer and C Stratowa
Ernst Boehringer Institut, Bender & Co., Vienna, Austria.

Human intercellular adhesion molecule-1 (ICAM-1), a specific ligand for the lymphocyte function-associated Ag-1 (LFA-1), plays an important role in leukocyte-endothelial cell interactions. It is induced by proinflammatory cytokines such as IL-1, TNF-alpha, or IFN-gamma. However, little is known concerning the intracellular regulatory mechanisms which trigger ICAM-1 up-regulation. In order to study potential regulatory elements involved in ICAM-1 induction we have cloned the human ICAM-1 gene and 5 kb of its 5'-regulatory region. The sequence of the cDNA was found to be distributed over seven exons separated by six introns, whereby each of the five extracellular Ig- like domains of ICAM-1 is encoded by its own exon. The upstream sequence harbors a number of sequence motifs implicated in the regulation and expression of eukaryotic genes, including binding sites for the transcription factors SP-1, AP-1, and NF-kB. Primer extension and S1 nuclease analysis revealed two transcription initiation sites 319 bp and 41 bp upstream of the translation start site. Consensus TATA boxes were found at the expected positions about 25 bp upstream of both start sites. Reverse transcriptase polymerase chain reaction showed differential use of the two TATA boxes in A549 and HS913T cells. Both RNA seem to code for the same for of ICAM-1 protein. For regulation studies a 1.3-kb EcoRI/SalI fragment of the 5'-flanking region was used to promote transcription of a linked luciferase reporter gene in transient-transfection assays in A549 and HS913T cells. Treatment of A549 cells with IL-1 or TNF-alpha resulted in a two- or fourfold increase in luciferase activity. Furthermore, a sixfold induction could be achieved after treatment with the phorbol ester PMA. In contrast, agents that increase intracellular cAMP levels did not induce luciferase activity. Northern blot analysis was used to investigate the kinetics of ICAM-1 mRNA synthesis upon induction with TNF-alpha and PMA. These data suggest that the up-regulation of ICAM-1 by cytokines occurs at least partly at the transcriptional level. Deletion analysis of the 1.3-kb fragment of the 5'-flanking region revealed sequences responsible for promotion and inhibition of transcription. In particular, two functionally distinct regions have been characterized: a short fragment containing an NF-kB binding site has been shown to function as an activator, followed immediately downstream by a sequence acting as a silencer element. Therefore, ICAM-1 gene expression seems to be modulated by multiple cis-acting elements.


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
J. Xue, P. B. Thippegowda, G. Hu, K. Bachmaier, J. W. Christman, A. B. Malik, and C. Tiruppathi
NF-{kappa}B regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-{kappa}B site in the ICAM-1 gene
Physiol Genomics, June 10, 2009; 38(1): 42 - 53.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Morimoto, J. Gosselink, A. Kartono, J. C. Hogg, S. Hayashi, and E. Ogawa
Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter
Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L361 - L371.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. J. Manzel, C. L. Chin, M. A. Behlke, and D. C. Look
Regulation of Bacteria-Induced Intercellular Adhesion Molecule-1 by CCAAT/Enhancer Binding Proteins
Am. J. Respir. Cell Mol. Biol., February 1, 2009; 40(2): 200 - 210.
[Abstract] [Full Text] [PDF]

Home page
 DMMHome page
H. Y. Stevens, B. Melchior, K. S. Bell, S. Yun, J.-C. Yeh, and J. A. Frangos
PECAM-1 is a critical mediator of atherosclerosis
Dis. Model. Mech., September 1, 2008; 1(2-3): 175 - 181.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Pirillo, P. Uboldi, C. Bolego, H. Kuhn, and A. L. Catapano
The 15-Lipoxygenase-Modified High Density Lipoproteins 3 Fail to Inhibit the TNF-{alpha}-Induced Inflammatory Response in Human Endothelial Cells
J. Immunol., August 15, 2008; 181(4): 2821 - 2830.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Sawa, T. Ueki, M. Hata, K. Iwasawa, E. Tsuruga, H. Kojima, H. Ishikawa, and S. Yoshida
LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 Expression in Human Lymphatic Endothelium
J. Histochem. Cytochem., February 1, 2008; 56(2): 97 - 109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Ichiki, M. Jougasaki, M. Setoguchi, J. Imamura, H. Nakashima, T. Matsuoka, M. Sonoda, K. Nakamura, S. Minagoe, and C. Tei
Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H750 - H763.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. El Mjiyad, S. Bontems, G. Gloire, J. Horion, P. Vandevenne, E. Dejardin, J. Piette, and C. Sadzot-Delvaux
Varicella-Zoster Virus Modulates NF-{kappa}B Recruitment on Selected Cellular Promoters
J. Virol., December 1, 2007; 81(23): 13092 - 13104.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Horion, G. Gloire, N. El Mjiyad, V. Quivy, L. Vermeulen, W. Vanden Berghe, G. Haegeman, C. Van Lint, J. Piette, and Y. Habraken
Histone Deacetylase Inhibitor Trichostatin A Sustains Sodium Pervanadate-induced NF-{kappa}B Activation by Delaying I{kappa}B{alpha} mRNA Resynthesis: COMPARISON WITH TUMOR NECROSIS FACTOR {alpha}
J. Biol. Chem., May 25, 2007; 282(21): 15383 - 15393.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y.-C. Lin, C.-T. Shun, M.-S. Wu, and C.-C. Chen
A Novel Anticancer Effect of Thalidomide: Inhibition of Intercellular Adhesion Molecule-1-Mediated Cell Invasion and Metastasis through Suppression of Nuclear Factor-{kappa}B
Clin. Cancer Res., December 1, 2006; 12(23): 7165 - 7173.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J.-T. Chen, J.-B. Liang, C.-L. Chou, M.-W. Chien, R.-C. Shyu, P.-I Chou, and D.-W. Lu
Glucosamine Sulfate Inhibits TNF-{alpha} and IFN-{gamma}-Induced Production of ICAM-1 in Human Retinal Pigment Epithelial Cells In Vitro
Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 664 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
N. Miho, T. Ishida, N. Kuwaba, M. Ishida, K. Shimote-Abe, K. Tabuchi, T. Oshima, M. Yoshizumi, and K. Chayama
Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells
Cardiovasc Res, November 1, 2005; 68(2): 289 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Qin, L. A. Borges-Marcucci, M. J. Evans, and D. C. Harnish
Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes
Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G267 - G273.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
V Yadav, G Marracci, J Lovera, W Woodward, K Bogardus, W Marquardt, L Shinto, C Morris, and D Bourdette
Lipoic acid in multiple sclerosis: a pilot study
Multiple Sclerosis, April 1, 2005; 11(2): 159 - 165.
[Abstract] [PDF]

Home page
 J. Nutr.Home page
V. Stangl, M. Lorenz, A. Ludwig, N. Grimbo, C. Guether, W. Sanad, S. Ziemer, P. Martus, G. Baumann, and K. Stangl
The Flavonoid Phloretin Suppresses Stimulated Expression of Endothelial Adhesion Molecules and Reduces Activation of Human Platelets
J. Nutr., February 1, 2005; 135(2): 172 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J Biomol ScreenHome page
R. L. Yauch, E. E. Kadel III, C. Nicholas, S. Tetangco, and D. O. Clary
Transcriptional-Based Screens for Pathway-Specific, High-Throughput Target Discovery in Endothelial Cells
J Biomol Screen, December 1, 2004; 9(8): 704 - 711.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
K. N. Anwar, F. Fazal, A. B. Malik, and A. Rahman
RhoA/Rho-Associated Kinase Pathway Selectively Regulates Thrombin-Induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells via Activation of I{kappa}B Kinase {beta} and Phosphorylation of RelA/p65
J. Immunol., December 1, 2004; 173(11): 6965 - 6972.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Wessells, M. Baer, H. A. Young, E. Claudio, K. Brown, U. Siebenlist, and P. F. Johnson
BCL-3 and NF-{kappa}B p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages
J. Biol. Chem., November 26, 2004; 279(48): 49995 - 50003.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Walter, J. Zahlten, B. Schmeck, C. Schaudinn, S. Hippenstiel, E. Frisch, A. C. Hocke, N. Pischon, H. K. Kuramitsu, J.-P. Bernimoulin, et al.
Porphyromonas gingivalis Strain-Dependent Activation of Human Endothelial Cells
Infect. Immun., October 1, 2004; 72(10): 5910 - 5918.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
W.-C. Huang, S.-T. Chan, T.-L. Yang, C.-C. Tzeng, and C.-C. Chen
Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel {alpha}-methylene-{gamma}-butyrolactone derivatives
Carcinogenesis, October 1, 2004; 25(10): 1925 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. P. Choudhury, J. X. Rong, E. Trogan, V. I. Elmalem, H. M. Dansky, J. L. Breslow, J. L. Witztum, J. T. Fallon, and E. A. Fisher
High-Density Lipoproteins Retard the Progression of Atherosclerosis and Favorably Remodel Lesions Without Suppressing Indices of Inflammation or Oxidation
Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1904 - 1909.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Bro, F. Moeller, C. B. Andersen, K. Olgaard, and L. B. Nielsen
Increased Expression of Adhesion Molecules in Uremic Atherosclerosis in Apolipoprotein-E-Deficient Mice
J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1495 - 1503.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. Amann, M.-L. Gross, and E. Ritz
Pathophysiology Underlying Accelerated Atherogenesis in Renal Disease: Closing in on the Target
J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1664 - 1666.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J.-J. Chiu, P.-L. Lee, C.-N. Chen, C.-I Lee, S.-F. Chang, L.-J. Chen, S.-C. Lien, Y.-C. Ko, S. Usami, and S. Chien
Shear Stress Increases ICAM-1 and Decreases VCAM-1 and E-selectin Expressions Induced by Tumor Necrosis Factor-{alpha} in Endothelial Cells
Arterioscler Thromb Vasc Biol, January 1, 2004; 24(1): 73 - 79.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Wang, B. Walia, J. Evans, A. T. Gewirtz, D. Merlin, and S. V. Sitaraman
IL-6 Induces NF-{kappa}B Activation in the Intestinal Epithelia
J. Immunol., September 15, 2003; 171(6): 3194 - 3201.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. M. Carter, S. Ali, and J. A. Kirby
Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate
J. Cell Sci., September 1, 2003; 116(17): 3591 - 3600.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Page, J. Li, L. Zhou, S. Iasvoyskaia, K. C. Corbit, J.-W. Soh, I. B. Weinstein, A. R. Brasier, A. Lin, and M. B. Hershenson
Regulation of Airway Epithelial Cell NF-{kappa}B-Dependent Gene Expression by Protein Kinase C{delta}
J. Immunol., June 1, 2003; 170(11): 5681 - 5689.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-C. Huang, J.-J. Chen, and C.-C. Chen
c-Src-dependent Tyrosine Phosphorylation of IKKbeta Is Involved in Tumor Necrosis Factor-alpha -induced Intercellular Adhesion Molecule-1 Expression
J. Biol. Chem., March 7, 2003; 278(11): 9944 - 9952.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. J. Terol, M. Tormo, J. A. Martinez-Climent, I. Marugan, I. Benet, A. Ferrandez, A. Teruel, R. Ferrer, and J. Garcia-Conde
Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome
Ann. Onc., March 1, 2003; 14(3): 467 - 474.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
M Iwata, N Fushimi, Y Suzuki, M Suzuki, T Sakimoto, and M Sawa
Intercellular adhesion molecule-1 expression on human corneal epithelial outgrowth from limbal explant in culture
Br J Ophthalmol, February 1, 2003; 87(2): 203 - 207.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. Stehlik, L. Fiorentino, A. Dorfleutner, J.-M. Bruey, E. M. Ariza, J. Sagara, and J. C. Reed
The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor {kappa}B Activation Pathways
J. Exp. Med., December 16, 2002; 196(12): 1605 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Rocha, R. F. Franco, R. Porcher, H. Bittencourt, W. A. Silva Jr, A. Latouche, A. Devergie, H. Esperou, P. Ribaud, G. Socie, et al.
Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation
Blood, December 1, 2002; 100(12): 3908 - 3918.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Rahman, A. L. True, K. N. Anwar, R. D. Ye, T. A. Voyno-Yasenetskaya, and A. B. Malik
G{alpha}q and G{beta}{gamma} Regulate PAR-1 Signaling of Thrombin-Induced NF-{kappa}B Activation and ICAM-1 Transcription in Endothelial Cells
Circ. Res., September 6, 2002; 91(5): 398 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
G. Weigel, P. Bertalanffy, and E. Wolner
Depletion of Intracellular GTP Results in Nuclear Factor-kappa B Activation and Intercellular Adhesion Molecule-1 Expression in Human Endothelial Cells
Mol. Pharmacol., September 1, 2002; 62(3): 453 - 462.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Besch, C. Giovannangeli, C. Kammerbauer, and K. Degitz
Specific Inhibition of ICAM-1 Expression Mediated by Gene Targeting with Triplex-forming Oligonucleotides
J. Biol. Chem., August 30, 2002; 277(36): 32473 - 32479.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. L. Mehta and D. Li
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor
J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1429 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. A. Pettersen and K. B. Adler
Airways Inflammation and COPD* : Epithelial-Neutrophil Interactions
Chest, May 1, 2002; 121 (2009): 142S - 150S.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. D. Silverman, R. J. Tumuluri, M. Davis, G. Lopez, J. T. Rosenbaum, and P. I. Lelkes
Homocysteine Upregulates Vascular Cell Adhesion Molecule-1 Expression in Cultured Human Aortic Endothelial Cells and Enhances Monocyte Adhesion
Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 587 - 592.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-J. Chang, M. J. Holtzman, and C.-C. Chen
Interferon-gamma -induced Epithelial ICAM-1 Expression and Monocyte Adhesion. INVOLVEMENT OF PROTEIN KINASE C-DEPENDENT c-Src TYROSINE KINASE ACTIVATION PATHWAY
J. Biol. Chem., February 22, 2002; 277(9): 7118 - 7126.
[Abstract] [Full Text] [PDF]

Home page
 J Biomol ScreenHome page
G. F. Davis, T. R. Downs, J. A. Farmer, C. R. Pierson, J. T. Roesgen, E. J. Cabrera, and S. L. Nelson
Comparison of High Throughput Screening Technologies for Luminescence Cell-Based Reporter Screens
J Biomol Screen, February 1, 2002; 7(1): 67 - 77.
[Abstract] [PDF]

Home page
 FASEB J.Home page
W.-J. ZHANG and B. FREI
{alpha}-Lipoic acid inhibits TNF-{alpha}-induced NF-{kappa}B activation and adhesion molecule expression in human aortic endothelial cells
FASEB J, November 1, 2001; 15(13): 2423 - 2432.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. Fuhrmann, M. Arvand, A. Gohler, M. Schmid, M. Krull, S. Hippenstiel, J. Seybold, C. Dehio, and N. Suttorp
Bartonella henselae Induces NF-{kappa}B-Dependent Upregulation of Adhesion Molecules in Cultured Human Endothelial Cells: Possible Role of Outer Membrane Proteins as Pathogenic Factors
Infect. Immun., August 1, 2001; 69(8): 5088 - 5097.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Katoh, Y. Kurosawa, K. Tanaka, A. Watanabe, H. Doi, and H. Narita
Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H655 - H660.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C.-C. Chen, J.-J. Chen, and C.-Y. Chou
Protein Kinase Calpha but not p44/42 Mitogen-Activated Protein Kinase, p38, or c-Jun NH2-Terminal Kinase Is Required for Intercellular Adhesion Molecule-1 Expression Mediated by Interleukin-1beta : Involvement of Sequential Activation of Tyrosine Kinase, Nuclear Factor-kappa B-Inducing Kinase, and Ikappa B Kinase 2
Mol. Pharmacol., April 13, 2001; 58(6): 1479 - 1489.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
K. R. Aupperle, B. L. Bennett, Z. Han, D. L. Boyle, A. M. Manning, and G. S. Firestein
NF-{{kappa}}B Regulation by I{{kappa}}B Kinase-2 in Rheumatoid Arthritis Synoviocytes
J. Immunol., February 15, 2001; 166(4): 2705 - 2711.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y. Amrani, A. L. Lazaar, R. Hoffman, K. Amin, S. Ousmer, and R. A. Panettieri Jr.
Activation of p55 Tumor Necrosis Factor-alpha Receptor-1 Coupled to Tumor Necrosis Factor Receptor-Associated Factor 2 Stimulates Intercellular Adhesion Molecule-1 Expression by Modulating a Thapsigargin-Sensitive Pathway in Human Tracheal Smooth Muscle Cells
Mol. Pharmacol., July 1, 2000; 58(1): 237 - 245.
[Abstract] [Full Text]

Home page
 Rheumatology (Oxford)Home page
T. Tomita, H. Takano, N. Tomita, R. Morishita, M. Kaneko, K. Shi, K. Takahi, T. Nakase, Y. Kaneda, H. Yoshikawa, et al.
Transcription factor decoy for NF{kappa}B inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis
Rheumatology, July 1, 2000; 39(7): 749 - 757.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. M. Krunkosky, B. M. Fischer, L. D. Martin, N. Jones, N. J. Akley, and K. B. Adler
Effects of TNF-alpha on Expression of ICAM-1 in Human Airway Epithelial Cells In Vitro . Signaling Pathways Controlling Surface and Gene Expression
Am. J. Respir. Cell Mol. Biol., June 1, 2000; 22(6): 685 - 692.
[Abstract] [Full Text]

Home page
 BloodHome page
Y.-T. Shiu, M. M. Udden, and L. V. McIntire
Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells
Blood, May 15, 2000; 95(10): 3232 - 3241.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Cominacini, A. F. Pasini, U. Garbin, A. Davoli, M. L. Tosetti, M. Campagnola, A. Rigoni, A. M. Pastorino, V. Lo Cascio, and T. Sawamura
Oxidized Low Density Lipoprotein (ox-LDL) Binding to ox-LDL Receptor-1 in Endothelial Cells Induces the Activation of NF-kappa B through an Increased Production of Intracellular Reactive Oxygen Species
J. Biol. Chem., April 21, 2000; 275(17): 12633 - 12638.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Mori, A. Wada, T. Hirayama, T. P. Parks, C. Stratowa, and N. Yamamoto
Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter pylori Is Regulated by NF-kappa B in Gastric Epithelial Cancer Cells
Infect. Immun., April 1, 2000; 68(4): 1806 - 1814.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Tsukamoto, M. Lin, M. Ohata, C. Giulivi, S. W. French, and G. Brittenham
Iron primes hepatic macrophages for NF-kappa B activation in alcoholic liver injury
Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1240 - G1250.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Z.-q. Yan, A. Sirsjo, M.-L. Bochaton-Piallat, G. Gabbiani, and G. K. Hansson
Augmented Expression of Inducible NO Synthase in Vascular Smooth Muscle Cells During Aging Is Associated With Enhanced NF-{kappa}B Activation
Arterioscler Thromb Vasc Biol, December 1, 1999; 19(12): 2854 - 2862.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Kobuchi, S. Roy, C. K. Sen, H. G. Nguyen, and L. Packer
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C403 - C411.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Keicho, Y. Higashimoto, G. P. Bondy, W. M. Elliott, J. C. Hogg, and S. Hayashi
Endotoxin-specific NF-kappa B activation in pulmonary epithelial cells harboring adenovirus E1A
Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L523 - L532.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Bourke and P. N. Moynagh
Antiinflammatory Effects of Glucocorticoids in Brain Cells, Independent of NF-{kappa}B
J. Immunol., August 15, 1999; 163(4): 2113 - 2119.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Amrani, A. L. Lazaar, and R. A. Panettieri Jr.
Up-Regulation of ICAM-1 by Cytokines in Human Tracheal Smooth Muscle Cells Involves an NF-{kappa}B-Dependent Signaling Pathway That Is Only Partially Sensitive to Dexamethasone
J. Immunol., August 15, 1999; 163(4): 2128 - 2134.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Beauchamp, V. Richard, F. Tamion, F. Lallemand, J.-P. Lebreton, H. Vaudry, M. Daveau, and C. Thuillez
Protective Effects of Preconditioning in Cultured Rat Endothelial Cells : Effects on Neutrophil Adhesion and Expression of ICAM-1 After Anoxia and Reoxygenation
Circulation, August 3, 1999; 100(5): 541 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Koga, E. Sardina, R. M. Tidwell, M. Pelletier, D. C. Look, and M. J. Holtzman
Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization
PNAS, May 11, 1999; 96(10): 5680 - 5685.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Rahman, K. N. Anwar, A. L. True, and A. B. Malik
Thrombin-Induced p65 Homodimer Binding to Downstream NF-{kappa}B Site of the Promoter Mediates Endothelial ICAM-1 Expression and Neutrophil Adhesion
J. Immunol., May 1, 1999; 162(9): 5466 - 5476.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Krull, A. C. Klucken, F. N. Wuppermann, O. Fuhrmann, C. Magerl, J. Seybold, S. Hippenstiel, J. H. Hegemann, C. A. Jantos, and N. Suttorp
Signal Transduction Pathways Activated in Endothelial Cells Following Infection with Chlamydia pneumoniae
J. Immunol., April 15, 1999; 162(8): 4834 - 4841.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Kupatt, H. Habazettl, A. Goedecke, D. A. Wolf, S. Zahler, P. Boekstegers, R. A. Kelly, and B. F. Becker
Tumor Necrosis Factor-{alpha} Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts
Circ. Res., March 5, 1999; 84(4): 392 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Hsing and G. A. Bishop
Requirement for Nuclear Factor-{kappa}B Activation by a Distinct Subset of CD40-Mediated Effector Functions in B Lymphocytes
J. Immunol., March 1, 1999; 162(5): 2804 - 2811.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Tamaru and S. Narumi
E-selectin Gene Expression Is Induced Synergistically with the Coexistence of Activated Classic Protein Kinase C and Signals Elicited by Interleukin-1beta but Not Tumor Necrosis Factor-alpha
J. Biol. Chem., February 5, 1999; 274(6): 3753 - 3763.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. McKay, L. J. Miraglia, L. L. Cummins, S. R. Owens, H. Sasmor, and N. M. Dean
Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-alpha Expression
J. Biol. Chem., January 15, 1999; 274(3): 1715 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
H. Shin, I. Kitajima, T. Nakajima, Q. Shao, T. Tokioka, I. Takasaki, N. Hanyu, T. Kubo, and I. Maruyama
Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts
Ann Rheum Dis, January 1, 1999; 58(1): 55 - 60.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
V. Lakshminarayanan, E. A. Drab-Weiss, and K. A. Roebuck
H2O2 and Tumor Necrosis Factor-alpha Induce Differential Binding of the Redox-responsive Transcription Factors AP-1 and NF-kappa B to the Interleukin-8 Promoter in Endothelial and Epithelial Cells
J. Biol. Chem., December 4, 1998; 273(49): 32670 - 32678.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
O. Devergne, E. C. McFarland, G. Mosialos, K. M. Izumi, C. F. Ware, and E. Kieff
Role of the TRAF Binding Site and NF-kappa B Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression
J. Virol., October 1, 1998; 72(10): 7900 - 7908.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Tamaru, K. Tomura, S. Sakamoto, K. Tezuka, T. Tamatani, and S. Narumi
Interleukin-1ß Induces Tissue- and Cell Type–Specific Expression of Adhesion Molecules In Vivo
Arterioscler Thromb Vasc Biol, August 1, 1998; 18(8): 1292 - 1303.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Kageyama, Y. Koide1, A. Yoshida, M. Uchijima, T. Arai, S. Miyamoto, T. Ozeki, M. Hiyoshi, K. Kushida, and T. Inoue
Reduced Susceptibility to Collagen-Induced Arthritis in Mice Deficient in IFN-{gamma} Receptor
J. Immunol., August 1, 1998; 161(3): 1542 - 1548.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. S. Taylor, M. E. de Vera, R. W. Ganster, Q. Wang, R. A. Shapiro, S. M. Morris Jr., T. R. Billiar, and D. A. Geller
Multiple NF-kappa B Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene
J. Biol. Chem., June 12, 1998; 273(24): 15148 - 15156.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
F. Calara, P. Dimayuga, A. Niemann, J. Thyberg, U. Diczfalusy, J. L. Witztum, W. Palinski, P. K. Shah, B. Cercek, J. Nilsson, et al.
An Animal Model to Study Local Oxidation of LDL and Its Biological Effects in the Arterial Wall
Arterioscler Thromb Vasc Biol, June 1, 1998; 18(6): 884 - 893.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. J. Johnson, M. Stack, S. A. Hazlewood, M. Jones, C. G. Blackmore, L.-F. Hu, and M. Rowe
The 30-Base-Pair Deletion in Chinese Variants of the Epstein-Barr Virus LMP1 Gene Is Not the Major Effector of Functional Differences between Variant LMP1 Genes in Human Lymphocytes
J. Virol., May 1, 1998; 72(5): 4038 - 4048.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Sugiyama, K. Kugiyama, N. Ogata, H. Doi, Y. Ota, M. Ohgushi, T. Matsumura, H. Oka, and H. Yasue
Biphasic Regulation of Transcription Factor Nuclear Factor-{kappa}B Activity in Human Endothelial Cells by Lysophosphatidylcholine Through Protein Kinase C–Mediated Pathway
Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 568 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. Zhu, J. H.-C. Lin, H.-L. Liao, O. Friedli Jr, L. Verna, N. W. Marten, D. S. Straus, and M. B. Stemerman
LDL Induces Transcription Factor Activator Protein-1 in Human Endothelial Cells
Arterioscler Thromb Vasc Biol, March 1, 1998; 18(3): 473 - 480.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Lakshminarayanan, D. W. A. Beno, R. H. Costa, and K. A. Roebuck
Differential Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 by H2O2 and Tumor Necrosis Factor-alpha in Endothelial and Epithelial Cells
J. Biol. Chem., December 26, 1997; 272(52): 32910 - 32918.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J.J. Chiu, B.S. Wung, J. Y.J. Shyy, H.J. Hsieh, and D.L. Wang
Reactive Oxygen Species Are Involved in Shear Stress-Induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells
Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3570 - 3577.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Braun, P. Pietsch, A. Zepp, K. Schror, G. Baumann, and S. B. Felix
Regulation of Tumor Necrosis Factor-{alpha} and Interleukin-1ß Induced Adhesion Molecule Expression in Human Vascular Smooth Muscle Cells by cAMP
Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2568 - 2575.
[Abstract] [Full Text]

Home page
 BloodHome page
S. Song, H. Ling-Hu, K. A. Roebuck, M. F. Rabbi, R. P. Donnelly, and A. Finnegan
Interleukin-10 Inhibits Interferon-gamma -Induced Intercellular Adhesion Molecule-1 Gene Transcription in Human Monocytes
Blood, June 15, 1997; 89(12): 4461 - 4469.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ohmori, R. D. Schreiber, and T. A. Hamilton
Synergy between Interferon-gamma and Tumor Necrosis Factor-alpha in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor kappa B
J. Biol. Chem., June 6, 1997; 272(23): 14899 - 14907.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. F. Baker, S. S. Lot, T. P. Condon, S. Cheng-Flournoy, E. A. Lesnik, H. M. Sasmor, and C. F. Bennett
2'-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells
J. Biol. Chem., May 2, 1997; 272(18): 11994 - 12000.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
X.-L. L. Chen, P. E. Tummala, L. Olliff, and R. M. Medford
E-Selectin Gene Expression in Vascular Smooth Muscle Cells: Evidence for a Tissue-Specific Repressor Protein
Circ. Res., March 1, 1997; 80(3): 305 - 311.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. M. Smalley, J. H.-C. Lin, M. L. Curtis, Y. Kobari, M. B. Stemerman, and K. A. Pritchard Jr
Native LDL Increases Endothelial Cell Adhesiveness by Inducing Intercellular Adhesion Molecule–1
Arterioscler Thromb Vasc Biol, April 1, 1996; 16(4): 585 - 590.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
H. Ochi, N. Kume, E. Nishi, and T. Kita
Elevated Levels of cAMP Inhibit Protein Kinase C– Independent Mechanisms of Endothelial Platelet-Derived Growth Factor–B Chain and Intercellular Adhesion Molecule-1 Gene Induction by Lysophosphatidylcholine
Circ. Res., September 1, 1995; 77(3): 530 - 535.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. J. Bachurski, G. S. Pryhuber, S. W. Glasser, S. E. Kelly, and J. A. Whitsett
Tumor Necrosis Factor-alpha Inhibits Surfactant Protein C Gene Transcription
J. Biol. Chem., August 18, 1995; 270(33): 19402 - 19407.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. A. Roebuck, A. Rahman, V. Lakshminarayanan, K. Janakidevi, and A. B. Malik
H(2)O(2) and Tumor Necrosis Factor-alpha Activate Intercellular Adhesion Molecule 1 (ICAM-1) Gene Transcription through Distinct cis-Regulatory Elements within the ICAM-1 Promoter
J. Biol. Chem., August 11, 1995; 270(32): 18966 - 18974.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Weber, W. Erl, A. Pietsch, U. Danesch, and P. C. Weber
Docosahexaenoic Acid Selectively Attenuates Induction of Vascular Cell Adhesion Molecule–1 and Subsequent Monocytic Cell Adhesion to Human Endothelial Cells Stimulated by Tumor Necrosis Factor–{alpha}
Arterioscler Thromb Vasc Biol, May 1, 1995; 15(5): 622 - 628.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. C. Ledebur and T. P. Parks
Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells
J. Biol. Chem., January 13, 1995; 270(2): 933 - 943.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. S. Baldwin, H. M. Shen, H. C. Yan, H. M. DeLisser, A. Chung, C. Mickanin, T. Trask, N. E. Kirschbaum, P. J. Newman, S. M. Albelda, et al.
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development
Development, September 1, 1994; 120(9): 2539 - 2553.
[Abstract] [PDF]

Home page
 Innate ImmunityHome page
U. Schonbeck, H.-D. Flad, E. Th. Rietschel, E. Brandt, and H. Loppnow
S-form LPS induces leukocyte adhesion to human vascular endothelial cells as potent as IL-1: lipid A precursor Ia antagonizes induction of adhesion by LPS
Innate Immunity, March 1, 1994; 1(1): 4 - 13.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Mehl, J. E. Floettmann, M. Jones, P. Brennan, and M. Rowe
Characterization of Intercellular Adhesion Molecule-1 Regulation by Epstein-Barr Virus-encoded Latent Membrane Protein-1 Identifies Pathways That Cooperate with Nuclear Factor kappa B to Activate Transcription
J. Biol. Chem., January 5, 2001; 276(2): 984 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Trogan, R. P. Choudhury, H. M. Dansky, J. X. Rong, J. L. Breslow, and E. A. Fisher
Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice
PNAS, February 19, 2002; 99(4): 2234 - 2239.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. D. Silverman, R. J. Tumuluri, M. Davis, G. Lopez, J. T. Rosenbaum, and P. I. Lelkes
Homocysteine Upregulates Vascular Cell Adhesion Molecule-1 Expression in Cultured Human Aortic Endothelial Cells and Enhances Monocyte Adhesion
Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 587 - 592.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.