The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coutinho, G. C.
Right arrow Articles by Couraud, P. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coutinho, G. C.
Right arrow Articles by Couraud, P. O.

The Journal of Immunology, Vol 147, Issue 8 2525-2529, Copyright © 1991 by American Association of Immunologists

ARTICLES

Catecholamines stimulate the IFN-gamma-induced class II MHC expression on bovine brain capillary endothelial cells

GC Coutinho, O Durieu-Trautmann, AD Strosberg and PO Couraud
Laboratoire d'Immuno-Pharmacologie Moleculaire, UPR 0415 CNRS, Paris, France.

The brain has been considered for a long time as an immunologically privileged site because of the lack of a true lymphatic system and the existence of several barriers that isolate it from the periphery. In the last few years, it became evident that cells in the central nervous system (astrocytes, microglial cells, and brain capillary endothelial cells) can be induced to express class II MHC and present Ag to T lymphocytes. The brain capillary endothelial cells, which are strategically located at the interface between blood and brain, could be involved in the initiation of immune responses within the brain parenchyma. We have previously characterized bovine brain capillary endothelial cells in culture and shown that they maintain in vitro a fully differentiated phenotype associated with the blood-brain barrier endothelium. In order to assess the role of these cells in the development of immune responses in the brain, we initiated the present study on the regulation of their class II MHC surface expression. Our data indicate that this expression on bovine brain capillary endothelial cells is inducible by IFN-gamma and further stimulated by catecholamines through activation of beta-adrenergic receptors. However, this latter effect is not mimicked by forskolin, theophylline, or dibutyryl-cAMP, suggesting the involvement of a cAMP-independent mechanism.


This article has been cited by other articles:


Home page
 Psychosom. Med.Home page
K. F. Harris and K. A. Matthews
Interactions Between Autonomic Nervous System Activity and Endothelial Function: A Model for the Development of Cardiovascular Disease
Psychosom Med, March 1, 2004; 66(2): 153 - 164.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Etienne, S. Bourdoulous, A. D. Strosberg, and P.-O. Couraud
MHC Class II Engagement in Brain Endothelial Cells Induces Protein Kinase A-Dependent IL-6 Secretion and Phosphorylation of cAMP Response Element-Binding Protein
J. Immunol., October 1, 1999; 163(7): 3636 - 3641.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. K. Waddell, R. M. Gorczynski, K. N. DeCampos, G. A. Patterson, and A. S. Slutsky
Major Histocompatibility Complex Expression and Lung Ischemia-Reperfusion in Rats
Ann. Thorac. Surg., September 1, 1996; 62(3): 866 - 872.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1991 by The American Association of Immunologists, Inc. All rights reserved.