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The Journal of Immunology, Vol 147, Issue 8 2514-2517, Copyright © 1991 by American Association of Immunologists
ARTICLES |
Y Torimoto, NH Dang, E Vivier, T Tanaka, SF Schlossman and C Morimoto
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.
In the present report, we demonstrated that modulation of CD26 from T cell surface induced by antiCD26 (1F7) led to enhanced phosphorylation of CD3 zeta tyrosine residues and increased CD4 associated p56lck tyrosine kinase activity. We further showed that CD26 was comodulated on the T cell surface with CD45, a known membrane-linked protein tyrosine phosphatase and that anti-CD26 was capable of precipitating CD45 from T cell lysates. These findings strongly suggest that CD26 may be closely associated with the CD45 protein tyrosine phosphatase on T cell surface and further support the notion that the interaction of CD26 with CD45 results in enhanced tyrosine kinase activity, zeta chain phosphorylation, and T cell activation.
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