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The Journal of Immunology, Vol 147, Issue 8 2461-2466, Copyright © 1991 by American Association of Immunologists

ARTICLES

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells

MK Jenkins, PS Taylor, SD Norton and KB Urdahl
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.

CD4+ T cells require two signals to produce maximal amounts of IL-2, i.e., TCR occupancy and an unidentified APC-derived costimulus. Here we show that this costimulatory signal can be delivered by the T cell molecule CD28. An agonistic anti-CD28 mAb, but not IL-1 and/or IL-6, stimulated T cell proliferation by tetanus toxoid-specific T cells cultured with Ag-pulsed, costimulation-deficient APC. Furthermore, the ability of B cell tumor lines to provide costimulatory signals to purified T cells correlated well with expression of the CD28 ligand B7/BB-1. Finally, like anti-CD28 mAb, autologous human APC appeared to stimulate a cyclosporine A-resistant pathway of T cell activation. Together, these results suggest that the two signals required for IL-2 production by CD4+ T cells can be transduced by the TCR and CD28.


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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
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J. Immunol., June 15, 1999; 162(12): 7031 - 7040.
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Home page
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 J. Immunol.Home page
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J. Immunol., May 1, 1999; 162(9): 5037 - 5040.
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Home page
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Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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J. Immunol., October 15, 1998; 161(8): 3919 - 3924.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
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J. Exp. Med., August 17, 1998; 188(4): 619 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
 J. Immunol.Home page
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Home page
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